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MeSH Review


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Disease relevance of Urticaria


Psychiatry related information on Urticaria

  • Before the onset of urticaria, there were changes in the life-style and considerable stress in daily life as well as exposure to an allergen [6].
  • The response of both the urticaria and panic disorder to selective serotonin reuptake inhibitor antidepressants may suggest a common pathogenic factor involving serotoninergic mechanisms [7].

High impact information on Urticaria


Chemical compound and disease context of Urticaria


Biological context of Urticaria


Anatomical context of Urticaria

  • Ionophore stimulation of aliquots of the same leukocytes used for anti-IgE challenge demonstrated that the urticaria patients' basophils were capable of releasing normal amounts of histamine [23].
  • These data indicate that chronic urticaria patients have a (acquired?) defect in leukocyte histamine release that occurs after the anti-IgE-IgE interaction, but before the actual (second-stage) release process, and that is comparable to the phenomenon of desensitization [23].
  • Treatment with oral medroxyprogesterone resulted in remission of urticaria and a decrease in eosinophil counts [24].
  • Antihistamine use alone may be unsuccessful in urticaria in which polymorphonuclear neutrophils predominate; frequently, the addition of agents that alter polymorphonuclear neutrophil function, such as colchicine or dapsone, is required [25].
  • BACKGROUND: Previous studies have demonstrated infiltration of eosinophils, neutrophils, monocytes, and T cells in the skin of patients with chronic idiopathic urticaria (CIU), suggesting a possible T(H)2-type cytokine pathology analogous to the allergen-induced skin late-phase reaction (LPR) [26].

Gene context of Urticaria


Analytical, diagnostic and therapeutic context of Urticaria

  • A patient receiving adjuvant chemoimmunotherapy for breast carcinoma developed urticaria secondary to cyclophosphamide, one of the drugs of the chemotherapy regimen [31].
  • During evaluation she repeatedly developed generalized punctate urticaria, pruritus, palpitations, and headaches after warm baths or exercise, and she had a positive methacholine skin test [32].
  • This double-blind study evaluated the safety and efficacy of astemizole in the treatment of chronic idiopathic urticaria (more than or equal to 3 months) [33].
  • In a screening of 271 sera, IL-1 alpha BF was detected in 17/98 normal subjects and was not more frequent in several control groups of patients, except in patients with Schnitzler's syndrome (fever, chronic urticaria, bone pain, and monoclonal IgM paraprotein) (6/9; p less than 0.005) [34].
  • BACKGROUND: Approximately 35% to 40% of patients with chronic urticaria possess a circulating antibody directed to the alpha subunit of the high-affinity type I IgE receptor (FcepsilonRI), which is detectable by using histamine release assays or immunoblotting [35].


  1. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. Soter, N.A., Wasserman, S.I., Austen, K.F. N. Engl. J. Med. (1976) [Pubmed]
  2. Clinical profile of angioedema associated with angiotensin converting-enzyme inhibition. Slater, E.E., Merrill, D.D., Guess, H.A., Roylance, P.J., Cooper, W.D., Inman, W.H., Ewan, P.W. JAMA (1988) [Pubmed]
  3. Complement in allergy and asthma. Gerard, N.P., Gerard, C. Curr. Opin. Immunol. (2002) [Pubmed]
  4. Inflammation and the mechanism of action of anti-inflammatory drugs. Vane, J., Botting, R. FASEB J. (1987) [Pubmed]
  5. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Chiao, C., Carothers, A.M., Grunberger, D., Solomon, G., Preston, G.A., Barrett, J.C. Cancer Res. (1995) [Pubmed]
  6. Psychosomatic aspects of skin diseases from the standpoint of immunology. Teshima, H., Kubo, C., Kihara, H., Imada, Y., Nagata, S., Ago, Y., Ikemi, Y. Psychotherapy and psychosomatics. (1982) [Pubmed]
  7. Chronic idiopathic urticaria associated with panic disorder: a syndrome responsive to selective serotonin reuptake inhibitor antidepressants? Gupta, M.A., Gupta, A.K. Cutis; cutaneous medicine for the practitioner. (1995) [Pubmed]
  8. Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. Hide, M., Francis, D.M., Grattan, C.E., Hakimi, J., Kochan, J.P., Greaves, M.W. N. Engl. J. Med. (1993) [Pubmed]
  9. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. Boyer, K.M., Gotoff, S.P. N. Engl. J. Med. (1986) [Pubmed]
  10. Urticaria from contact with pentachlorophenate. Kentor, P.M. JAMA (1986) [Pubmed]
  11. Hyperparathyroidism and urticaria. Liechty, R.D., Firminger, H.I. JAMA (1983) [Pubmed]
  12. Urticaria following intravenous doxorubicin administration. Souhami, L., Feld, R. JAMA (1978) [Pubmed]
  13. Cimetidine in chronic urticaria. Kaiser, H.B., Weisberg, S.C., Morris, R.J. Lancet (1980) [Pubmed]
  14. Is benzoic acid really harmful in cases of atopy and urticaria? Lahti, A., Hannuksela, M. Lancet (1981) [Pubmed]
  15. Adrenergic urticaria: a new form of stress-induced hives. Shelley, W.B., Shelley, E.D. Lancet (1985) [Pubmed]
  16. Induced tolerance in cold urticaria caused by cold-evoked histamine release. Bentley-Phillips, C.B., Black, A.K., Greaves, M.W. Lancet (1976) [Pubmed]
  17. Cutaneous responses to vasoactive intestinal polypeptide in chronic idiopathic urticaria. Smith, C.H., Atkinson, B., Morris, R.W., Hayes, N., Foreman, J.C., Lee, T.H. Lancet (1992) [Pubmed]
  18. Exercise-induced anaphylactic syndromes. Insights into diagnostic and pathophysiologic features. Casale, T.B., Keahey, T.M., Kaliner, M. JAMA (1986) [Pubmed]
  19. C1-bypass complement-activation pathway in patients with chronic urticaria and angio-oedema. Ballow, M., Ward, G.W., Gershwin, M.E., Day, N.K. Lancet (1975) [Pubmed]
  20. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Feldmann, J., Prieur, A.M., Quartier, P., Berquin, P., Certain, S., Cortis, E., Teillac-Hamel, D., Fischer, A., de Saint Basile, G. Am. J. Hum. Genet. (2002) [Pubmed]
  21. Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria. Simons, F.E., Sussman, G.L., Simons, K.J. J. Allergy Clin. Immunol. (1995) [Pubmed]
  22. Upregulation of TNF-alpha and IL-3 expression in lesional and uninvolved skin in different types of urticaria. Hermes, B., Prochazka, A.K., Haas, N., Jurgovsky, K., Sticherling, M., Henz, B.M. J. Allergy Clin. Immunol. (1999) [Pubmed]
  23. Defective histamine release in chronic urticaria. Kern, F., Lichtenstein, L.M. J. Clin. Invest. (1976) [Pubmed]
  24. Progesterone-responsive urticaria and eosinophilia. Mittman, R.J., Bernstein, D.I., Steinberg, D.R., Enrione, M., Bernstein, I.L. J. Allergy Clin. Immunol. (1989) [Pubmed]
  25. Chronic urticaria: pathophysiology and treatment approaches. Tharp, M.D. J. Allergy Clin. Immunol. (1996) [Pubmed]
  26. TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. Ying, S., Kikuchi, Y., Meng, Q., Kay, A.B., Kaplan, A.P. J. Allergy Clin. Immunol. (2002) [Pubmed]
  27. New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Dodé, C., Le Dû, N., Cuisset, L., Letourneur, F., Berthelot, J.M., Vaudour, G., Meyrier, A., Watts, R.A., Scott, D.G., Nicholls, A., Granel, B., Frances, C., Garcier, F., Edery, P., Boulinguez, S., Domergues, J.P., Delpech, M., Grateau, G. Am. J. Hum. Genet. (2002) [Pubmed]
  28. Human dermal endothelial cells express membrane-associated mast cell growth factor. Weiss, R.R., Whitaker-Menezes, D., Longley, J., Bender, J., Murphy, G.F. J. Invest. Dermatol. (1995) [Pubmed]
  29. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria. Papadopoulou, N., Kalogeromitros, D., Staurianeas, N.G., Tiblalexi, D., Theoharides, T.C. J. Invest. Dermatol. (2005) [Pubmed]
  30. Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. Zembowicz, A., Mastalerz, L., Setkowicz, M., Radziszewski, W., Szczeklik, A. Archives of dermatology. (2003) [Pubmed]
  31. Cyclophosphamide-induced urticaria. Occurrence in a patient with no cross-sensitivity to chlorambucil. Krutchik, A.N., Buzdar, A.U., Tashima, C.K. Arch. Intern. Med. (1978) [Pubmed]
  32. Evaluation of a patient with both aquagenic and cholinergic urticaria. Davis, R.S., Remigio, L.K., Schocket, A.L., Bock, S.A. J. Allergy Clin. Immunol. (1981) [Pubmed]
  33. The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. Fox, R.W., Lockey, R.F., Bukantz, S.C., Serbousek, D. J. Allergy Clin. Immunol. (1986) [Pubmed]
  34. Anti-interleukin-1 alpha autoantibodies in humans: characterization, isotype distribution, and receptor-binding inhibition--higher frequency in Schnitzler's syndrome (urticaria and macroglobulinemia). Saurat, J.H., Schifferli, J., Steiger, G., Dayer, J.M., Didierjean, L. J. Allergy Clin. Immunol. (1991) [Pubmed]
  35. Mechanisms of autoimmune activation of basophils in chronic urticaria. Kikuchi, Y., Kaplan, A.P. J. Allergy Clin. Immunol. (2001) [Pubmed]
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