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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.

In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02--20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002--0.2 nmol), an antagonist of the NMDA receptor polyamine binding site, decreased test step-down latencies. On the other hand, co-administration of arcaine and spermidine completely reversed the spermidine-induced increase of test step-down latencies. These results provide evidence that polyamines may be involved in learning and memory modulation in the amygdala.[1]

References

  1. Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats. Rubin, M.A., Stiegemeier, J.A., Volkweis, M.A., Oliveira, D.M., Fenili, A.C., Boemo, R.L., Jurach, A., Mello, C.F. Eur. J. Pharmacol. (2001) [Pubmed]
 
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