The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Avoidance Learning

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Avoidance Learning


Psychiatry related information on Avoidance Learning


High impact information on Avoidance Learning

  • Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain [10].
  • Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood [11].
  • The MAOA-deficient mice exhibited significantly enhanced classical fear conditioning (freezing to both tone and contextual stimuli) and step-down inhibitory avoidance learning [12].
  • We used the GABA(A) agonist muscimol to functionally inactivate these nuclei immediately after single-trial Pavlovian fear conditioning or single-trial inhibitory avoidance learning [13].
  • We have previously demonstrated that the extent of the IIP-MF subfield is positively correlated with the capacity to perform a spatial radial-maze task and that an experimentally induced enlargement of the IIP-MFs, by means of postnatal thyroxine treatment, predicted the ability of adult two-way avoidance learning [14].

Chemical compound and disease context of Avoidance Learning


Biological context of Avoidance Learning


Anatomical context of Avoidance Learning


Gene context of Avoidance Learning

  • This does not appear to be due to a learning deficit because mice lacking both DARPP-32 and I-1 show normal passive avoidance learning [30].
  • Thus, our results indicate that endogenous BDNF is required for both STM and LTM formation of inhibitory avoidance learning, possibly involving CREB activation-dependent mechanisms [31].
  • On the other hand, CRF (1.0 microg) consistently and markedly improved retention performance in rats in an inhibitory avoidance learning task [32].
  • The aim of the present study was to investigate the different neural substrates underlying short- and long-term inhibitory avoidance learning and memory in rats using phosphorylated extracellular signal-regulated kinase-1 and -2 labeling as an index of plasticity [20].
  • An administration of [Leu(13)-(psi-CH(2)NH)-Leu(14)]BN (antagonizes GRP-R>neuromedin B receptor (NMB-R)) impaired the performance of inhibitory avoidance learning in all doses (16, 32, 64 nmol/kg) [33].

Analytical, diagnostic and therapeutic context of Avoidance Learning


  1. Effect of propranolol treatment in pregnant rats on motor activity and avoidance learning of the offspring. Speiser, Z., Shved, A., Gitter, S. Psychopharmacology (Berl.) (1983) [Pubmed]
  2. Toluene exposure during the brain growth spurt reduces behavioral responses to noncompetitive N-methyl-D-aspartate receptor antagonists in adult rats. Chien, T.H., Chan, M.H., Tang, Y.C., Chen, H.H. Psychopharmacology (Berl.) (2005) [Pubmed]
  3. Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat. Asbury, E.T., Fritts, M.E., Horton, J.E., Isaac, W.L. Behav. Brain Res. (1998) [Pubmed]
  4. Prenatal alcohol exposure alters hippocampal slice electrophysiology. Tan, S.E., Berman, R.F., Abel, E.L., Zajac, C.S. Alcohol (1990) [Pubmed]
  5. Complex roles of glutamate in the Gibbs-Ng model of one-trial aversive learning in the new-born chick. Ng, K.T., O'Dowd, B.S., Rickard, N.S., Robinson, S.R., Gibbs, M.E., Rainey, C., Zhao, W.Q., Sedman, G.L., Hertz, L. Neuroscience and biobehavioral reviews. (1997) [Pubmed]
  6. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. Hashimoto, M., Hossain, S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J., Shido, O. J. Neurochem. (2002) [Pubmed]
  7. Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission. Nishii, K., Matsushita, N., Sawada, H., Sano, H., Noda, Y., Mamiya, T., Nabeshima, T., Nagatsu, I., Hata, T., Kiuchi, K., Yoshizato, H., Nakashima, K., Nagatsu, T., Kobayashi, K. J. Neurosci. Res. (1998) [Pubmed]
  8. Lesions of the basolateral amygdala complex block propofol-induced amnesia for inhibitory avoidance learning in rats. Alkire, M.T., Vazdarjanova, A., Dickinson-Anson, H., White, N.S., Cahill, L. Anesthesiology (2001) [Pubmed]
  9. Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats. Liang, K.C., Lee, E.H. Psychopharmacology (Berl.) (1988) [Pubmed]
  10. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Picciotto, M.R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., Le Novère, N., Vincent, P., Pich, E.M., Brûlet, P., Changeux, J.P. Nature (1995) [Pubmed]
  11. Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood. Bertolini, A., Poggioli, R. Science (1981) [Pubmed]
  12. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Kim, J.J., Shih, J.C., Chen, K., Chen, L., Bao, S., Maren, S., Anagnostaras, S.G., Fanselow, M.S., De Maeyer, E., Seif, I., Thompson, R.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. Wilensky, A.E., Schafe, G.E., LeDoux, J.E. J. Neurosci. (2000) [Pubmed]
  14. Early postnatal hyperthyroidism alters hippocampal circuitry and improves radial-maze learning in adult mice. Schwegler, H., Crusio, W.E., Lipp, H.P., Brust, I., Mueller, G.G. J. Neurosci. (1991) [Pubmed]
  15. Effect of midbrain raphe lesion on avoidance learning in aggressive mice. Valzelli, L., Bernasconi, S., Bohlken, S. Biol. Psychiatry (1976) [Pubmed]
  16. Vasopressin effect on learning in 6-hydroxydopamine-pretreated rats: correlation with caudate vasopressin levels. Hamburger-Bar, R., Ebstein, R.P., Belmaker, R.H. Biol. Psychiatry (1984) [Pubmed]
  17. Facilitation of memory by peripheral administration of substance P and naloxone using avoidance and habituation learning tasks. Tomaz, C., Aguiar, M.S., Nogueira, P.J. Neuroscience and biobehavioral reviews. (1990) [Pubmed]
  18. Effects of chronic alcohol feeding on thiamin status: biochemical and neurological correlates. Shaw, S., Gorkin, B.D., Lieber, C.S. Am. J. Clin. Nutr. (1981) [Pubmed]
  19. Active and passive avoidance learning in controls and schizophrenic patients on racemic propranolol and neuroleptics. Gruzelier, J., Thornton, S., Staniforth, D., Zaki, S., Yorkston, N. The British journal of psychiatry : the journal of mental science. (1980) [Pubmed]
  20. Differential patterns of extracellular signal-regulated kinase-1 and -2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning. Chai, S.C., Holahan, M.R., Shyu, B.C., Wang, C.C. Neuroscience (2006) [Pubmed]
  21. Effects of nicotine on active avoidance learning in rats: sex differences. Yilmaz, O., Kanit, L., Okur, B.E., Pöğün, S. Behavioural pharmacology. (1997) [Pubmed]
  22. Forebrain serotonin and avoidance learning: behavioural and biochemical studies on the acute effect of p-chloroamphetamine on one-way active avoidance learning in the male rat. Ogren, S.O. Pharmacol. Biochem. Behav. (1982) [Pubmed]
  23. Chronic intermittent ethyl alcohol inhalation and avoidance learning. Sotzing, J.H., Brown, T.S. Pharmacol. Biochem. Behav. (1976) [Pubmed]
  24. Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats. Yamazaki, N., Kiyota, Y., Take, Y., Miyamoto, M., Nagawa, Y., Nagaoka, A. Archives of gerontology and geriatrics. (1989) [Pubmed]
  25. Transient, learning-induced ultrastructural change in spatially-clustered dentate granule cells of the adult rat hippocampus. O'Connell, C., O'Malley, A., Regan, C.M. Neuroscience (1997) [Pubmed]
  26. Enhanced learning produced by injection of neurokinin substance P into the region of the nucleus basalis magnocellularis: mediation by the N-terminal sequence. Gerhardt, P., Hasenöhrl, R.U., Huston, J.P. Exp. Neurol. (1992) [Pubmed]
  27. Hippocampal cGMP and cAMP are differentially involved in memory processing of inhibitory avoidance learning. Bernabeu, R., Schmitz, P., Faillace, M.P., Izquierdo, I., Medina, J.H. Neuroreport (1996) [Pubmed]
  28. Blockade of cholinergic receptors by an irreversible antagonist, propylbenzilylcholine mustard (PrBCM), in the rat cerebral cortex causes deficits in passive avoidance learning. Fukuchi, I., Kato, S., Nakahiro, M., Uchida, S., Ishida, R., Yoshida, H. Brain Res. (1987) [Pubmed]
  29. Behavioral, endocrine, and neurochemical effects of sulfomucopolysaccharide treatment in the aged Fischer 344 male rat. Lorens, S.A., Guschwan, M., Hata, N., van de Kar, L.D., Walenga, J.M., Fareed, J. Semin. Thromb. Hemost. (1991) [Pubmed]
  30. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Zachariou, V., Benoit-Marand, M., Allen, P.B., Ingrassia, P., Fienberg, A.A., Gonon, F., Greengard, P., Picciotto, M.R. Biol. Psychiatry (2002) [Pubmed]
  31. Endogenous BDNF is required for long-term memory formation in the rat parietal cortex. Alonso, M., Bekinschtein, P., Cammarota, M., Vianna, M.R., Izquierdo, I., Medina, J.H. Learn. Mem. (2005) [Pubmed]
  32. Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. Ma, Y.L., Chen, K.Y., Wei, C.L., Lee, E.H. The Chinese journal of physiology. (1999) [Pubmed]
  33. Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Santo-Yamada, Y., Yamada, K., Wada, E., Goto, Y., Wada, K. Neurosci. Lett. (2003) [Pubmed]
  34. The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia. Gower, A.J., Tricklebank, M.D. Neuropharmacology (1986) [Pubmed]
  35. Involvement of the amygdala in the effect of antidepressants on the passive avoidance deficit in bulbectomised rats. Garrigou, D., Broekkamp, C.L., Lloyd, K.G. Psychopharmacology (Berl.) (1981) [Pubmed]
  36. Intraperitoneal injection of 1-oleoyl-2-docosahexaenoyl phosphatidylcholine enhances discriminatory shock avoidance learning in rats. Izaki, Y., Hashimoto, M., Arita, J., Iriki, M., Hibino, H. Neurosci. Lett. (1994) [Pubmed]
  37. Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats. Huang, A.M., Lee, E.H. Neuroreport (1997) [Pubmed]
  38. Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease. Wiley, R.G., Berbos, T.G., Deckwerth, T.L., Johnson, E.M., Lappi, D.A. J. Neurol. Sci. (1995) [Pubmed]
WikiGenes - Universities