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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Biotransformation of malachite green by the fungus Cunninghamella elegans.

The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.[1]


  1. Biotransformation of malachite green by the fungus Cunninghamella elegans. Cha, C.J., Doerge, D.R., Cerniglia, C.E. Appl. Environ. Microbiol. (2001) [Pubmed]
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