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Biotransformation of malachite green by the fungus Cunninghamella elegans.

The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.[1]

References

  1. Biotransformation of malachite green by the fungus Cunninghamella elegans. Cha, C.J., Doerge, D.R., Cerniglia, C.E. Appl. Environ. Microbiol. (2001) [Pubmed]
 
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