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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Surgical decision-making on cerebral cavernous malformations.

This study is an attempt to clarify surgical decision-making on cerebral cavernous malformations based on the data available in the literature. Using a mathematical model, we calculated the morbidity-free survival curves of the patients harboring cerebral cavernous malformations. Using these survival curves, we calculated the morbidity-free life expectancies of the patients at certain age undergoing either natural course or surgery. For superficially located lesions, permissible surgical risks were very small ranging from 0.4 to 2.8 percent of combined morbidity and mortality. The surgical gain of morbidity free life expectancy was also very small (0.0-1.1 years) irrespective of patient's age or eloquence of the location. For deep lesions, the permissible risk of surgery was very large, ranging from 64.1% for a 20-year-old and 31.4% for a 60-year-old patient. The gain of morbidity-free life expectancy was also large for younger patients (17-25 years for 20-year-old patients), but this gain rapidly decreased as the patient's age grew older, becoming 1.1 to 3.1 years for 60-year-old patients. Surgery seems to be justified for younger patients with deep lesions. There seems to be little indication for surgery of superficial lesions as far as the risk of bleeding is concerned.[1]


  1. Surgical decision-making on cerebral cavernous malformations. Chang, H.S., Hongo, K., Nakagawa, H., Tsuge, T. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. (2001) [Pubmed]
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