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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Decision Making

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Disease relevance of Decision Making


Psychiatry related information on Decision Making

  • However, brain activity and task performance were similar between the Moderate MJ users and the Control group, suggesting a "threshold effect". These preliminary findings indicate that very heavy users of MJ have persistent decision-making deficits and alterations in brain activity [6].
  • We also examined these patients with various other procedures designed to measure decision-making (the Gambling Task), social functioning, as well as personality changes and psychopathology; standardized neuropsychological tests were applied to assess their cognitive intelligence, executive functioning, perception and memory as well [7].
  • METHOD: Ten depressed and eight recovered psychosurgery patients, along with nine never-depressed subjects and nine who had recovered from depression with medication, completed the Iowa Gambling Task, a measure of decision making in the face of feedback [8].
  • OBJECTIVE: The study assessed the validity of the Gambling Task as a test of decision-making ability in adolescents and examined whether adolescents with behavior disorders, who are at risk for substance abuse, have deficits in decision making similar to those exhibited by adults with substance abuse [9].
  • Methylphenidate was effective in 'normalizing' the decision-making behavior of patients, such that they became less risk taking on medication, although there were no significant effects on other aspects of cognitive function, including working memory, attentional set shifting, and reversal learning [10].

High impact information on Decision Making

  • Signals from dynamic cellular interactions between the extracellular matrix and neighboring cells ultimately input into the cellular decision-making process [11].
  • The US Supreme Court recently accepted on appeal 2 cases from the University of Michigan regarding the constitutionality of race-conscious decision making in higher education admissions [12].
  • BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes [13].
  • In general, confidence intervals are too wide to allow decision making and patient feedback about an individual's cholesterol response to a dietary intervention, even with multiple measurements [14].
  • Research institutions with a variety of counseling programs, health care professionals, HD lay organizations, and society at large can work together to develop programs that provide the support necessary for responsible, autonomous decision making [15].

Chemical compound and disease context of Decision Making

  • We argue that there may be good reason to require a standard of admissibility that exceeds the standards of ordinary clinical decision making, but such requirements are not faithful to the mandate of the Supreme Court. Courts with especially demanding standards are misled if they believe that they are fairly representing medical practice [16].
  • Measuring and knowing. The trouble with cholesterol and decision making [17].
  • Gating of T cell voltage-gated K(+) channels (Kv1.3) appears to be the crucial "decision-making" step, through which various physiological factors, including elevated [K(+)](o) levels, affect the T cell beta1 integrin function: opening of the channel leads to function, whereas its blockage prevents it [18].
  • These results suggest that recurrent excitation mediated by NMDA receptors provides a candidate cellular mechanism for the slow time integration of sensory stimuli and the formation of categorical choices in a decision-making neocortical network [19].
  • A consensus-based approach to providing palliative care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine [20].

Biological context of Decision Making


Anatomical context of Decision Making


Gene context of Decision Making


Analytical, diagnostic and therapeutic context of Decision Making


  1. Controlled trial of pretest education approaches to enhance informed decision-making for BRCA1 gene testing. Lerman, C., Biesecker, B., Benkendorf, J.L., Kerner, J., Gomez-Caminero, A., Hughes, C., Reed, M.M. J. Natl. Cancer Inst. (1997) [Pubmed]
  2. Decision analysis and guidelines for anticoagulant therapy to prevent stroke in patients with atrial fibrillation. Thomson, R., Parkin, D., Eccles, M., Sudlow, M., Robinson, A. Lancet (2000) [Pubmed]
  3. The serum digoxin test and digoxin toxicity: a Bayesian approach to decision making. Eraker, S.A., Sasse, L. Circulation (1981) [Pubmed]
  4. 2-18fluoro-deoxy-D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial. De Santis, M., Becherer, A., Bokemeyer, C., Stoiber, F., Oechsle, K., Sellner, F., Lang, A., Kletter, K., Dohmen, B.M., Dittrich, C., Pont, J. J. Clin. Oncol. (2004) [Pubmed]
  5. Randomized trial of computer-assisted insulin delivery in patients with type I diabetes beginning pump therapy. Peterson, C.M., Jovanovic, L., Chanoch, L.H. Am. J. Med. (1986) [Pubmed]
  6. Neural substrates of faulty decision-making in abstinent marijuana users. Bolla, K.I., Eldreth, D.A., Matochik, J.A., Cadet, J.L. Neuroimage (2005) [Pubmed]
  7. Exploring the neurological substrate of emotional and social intelligence. Bar-On, R., Tranel, D., Denburg, N.L., Bechara, A. Brain (2003) [Pubmed]
  8. Neuropsychological processing associated with recovery from depression after stereotactic subcaudate tractotomy. Dalgleish, T., Yiend, J., Bramham, J., Teasdale, J.D., Ogilvie, A.D., Malhi, G., Howard, R. The American journal of psychiatry. (2004) [Pubmed]
  9. Decision making in adolescents with behavior disorders and adults with substance abuse. Ernst, M., Grant, S.J., London, E.D., Contoreggi, C.S., Kimes, A.S., Spurgeon, L. The American journal of psychiatry. (2003) [Pubmed]
  10. Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia. Rahman, S., Robbins, T.W., Hodges, J.R., Mehta, M.A., Nestor, P.J., Clark, L., Sahakian, B.J. Neuropsychopharmacology (2006) [Pubmed]
  11. Cell adhesion molecules, signal transduction and cell growth. Aplin, A.E., Howe, A.K., Juliano, R.L. Curr. Opin. Cell Biol. (1999) [Pubmed]
  12. The consequences of premature abandonment of affirmative action in medical school admissions. Cohen, J.J. JAMA (2003) [Pubmed]
  13. BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. Lerman, C., Narod, S., Schulman, K., Hughes, C., Gomez-Caminero, A., Bonney, G., Gold, K., Trock, B., Main, D., Lynch, J., Fulmore, C., Snyder, C., Lemon, S.J., Conway, T., Tonin, P., Lenoir, G., Lynch, H. JAMA (1996) [Pubmed]
  14. Estimating an individual's true cholesterol level and response to intervention. Irwig, L., Glasziou, P., Wilson, A., Macaskill, P. JAMA (1991) [Pubmed]
  15. Presymptomatic testing for Huntington's disease. Bird, S.J. JAMA (1985) [Pubmed]
  16. Inconsistency in evidentiary standards for medical testimony: disorder in the courts. Kassirer, J.P., Cecil, J.S. JAMA (2002) [Pubmed]
  17. Measuring and knowing. The trouble with cholesterol and decision making. Gwynne, J.T. JAMA (1991) [Pubmed]
  18. Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. Levite, M., Cahalon, L., Peretz, A., Hershkoviz, R., Sobko, A., Ariel, A., Desai, R., Attali, B., Lider, O. J. Exp. Med. (2000) [Pubmed]
  19. Probabilistic decision making by slow reverberation in cortical circuits. Wang, X.J. Neuron (2002) [Pubmed]
  20. A consensus-based approach to providing palliative care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Karlawish, J.H., Quill, T., Meier, D.E. Ann. Intern. Med. (1999) [Pubmed]
  21. Determination of the molecular relationship between multiple tumors within one patient is of clinical importance. van der Sijp, J.R., van Meerbeeck, J.P., Maat, A.P., Zondervan, P.E., Sleddens, H.F., van Geel, A.N., Eggermont, A.M., Dinjens, W.N. J. Clin. Oncol. (2002) [Pubmed]
  22. Hypoglycemic thresholds for cognitive dysfunction in humans. Blackman, J.D., Towle, V.L., Lewis, G.F., Spire, J.P., Polonsky, K.S. Diabetes (1990) [Pubmed]
  23. Clinical decision making on statin drug interactions. Williams, C.D. J. Am. Coll. Cardiol. (2003) [Pubmed]
  24. Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes. Huang, Y.H., Wu, J.Y., Zhang, Y., Wu, M.X. Oncogene (2002) [Pubmed]
  25. Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Bhattacharyya, A., Choudhuri, T., Pal, S., Chattopadhyay, S., K Datta, G., Sa, G., Das, T. Carcinogenesis (2003) [Pubmed]
  26. Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks. Schmitz, T.W., Johnson, S.C. Neuroimage (2006) [Pubmed]
  27. Sex-related differences in a gambling task and its neurological correlates. Bolla, K.I., Eldreth, D.A., Matochik, J.A., Cadet, J.L. Cereb. Cortex (2004) [Pubmed]
  28. Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T. Chu, W.J., Hetherington, H.P., Kuzniecky, R.I., Simor, T., Mason, G.F., Elgavish, G.A. Neurology (1998) [Pubmed]
  29. Effect of various agents on adenosine triphosphate synthesis in mitochondrial complex I deficiency. Bar-Meir, M., Elpeleg, O.N., Saada, A. J. Pediatr. (2001) [Pubmed]
  30. Migratory pathways and selective aggregation of the lateral reticular neurons in the rat embryo: a horseradish peroxidase in vitro study, with special reference to migration patterns of the precerebellar nuclei. Bourrat, F., Sotelo, C. J. Comp. Neurol. (1990) [Pubmed]
  31. The roles of integrin-linked kinase in the regulation of myogenic differentiation. Huang, Y., Li, J., Zhang, Y., Wu, C. J. Cell Biol. (2000) [Pubmed]
  32. Impact of BRCA1/BRCA2 counseling and testing on newly diagnosed breast cancer patients. Schwartz, M.D., Lerman, C., Brogan, B., Peshkin, B.N., Halbert, C.H., DeMarco, T., Lawrence, W., Main, D., Finch, C., Magnant, C., Pennanen, M., Tsangaris, T., Willey, S., Isaacs, C. J. Clin. Oncol. (2004) [Pubmed]
  33. Attitudes, knowledge, and risk perceptions of women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2. Bluman, L.G., Rimer, B.K., Berry, D.A., Borstelmann, N., Iglehart, J.D., Regan, K., Schildkraut, J., Winer, E.P. J. Clin. Oncol. (1999) [Pubmed]
  34. Role of estrogen receptor-alpha in pharmacogenetics of estrogen action. Herrington, D.M. Curr. Opin. Lipidol. (2003) [Pubmed]
  35. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Huang, S.F., Liu, H.P., Li, L.H., Ku, Y.C., Fu, Y.N., Tsai, H.Y., Chen, Y.T., Lin, Y.F., Chang, W.C., Kuo, H.P., Wu, Y.C., Chen, Y.R., Tsai, S.F. Clin. Cancer Res. (2004) [Pubmed]
  36. The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient? Caramori, M.L., Fioretto, P., Mauer, M. Diabetes (2000) [Pubmed]
  37. Neural substrates of decision making in adults with attention deficit hyperactivity disorder. Ernst, M., Kimes, A.S., London, E.D., Matochik, J.A., Eldreth, D., Tata, S., Contoreggi, C., Leff, M., Bolla, K. The American journal of psychiatry. (2003) [Pubmed]
  38. Prediction of the site and severity of obstruction in hypertrophic cardiomyopathy by color flow mapping and continuous wave Doppler echocardiography. Schwammenthal, E., Block, M., Schwartzkopff, B., Lösse, B., Borggrefe, M., Schulte, H.D., Bircks, W., Breithardt, G. J. Am. Coll. Cardiol. (1992) [Pubmed]
  39. Implantable cardioverter-defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: a role for genotyping in decision-making? Wichter, T., Breithardt, G. J. Am. Coll. Cardiol. (2005) [Pubmed]
  40. Perfusion abnormalities and decision making in cocaine dependence. Tucker, K.A., Potenza, M.N., Beauvais, J.E., Browndyke, J.N., Gottschalk, P.C., Kosten, T.R. Biol. Psychiatry (2004) [Pubmed]
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