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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells.

Most of cells exhibit low nuclear level of NF-kappaB. However, in some cell lines and tissues aberrantly activated NF-kappaB is playing an important role in cell motility, growth control and survival. Here we describe the result of decrease of constitutive NF-kappaB level in different adenocarcinoma cell lines. Treatment of mouse adenocarcinoma cell line CSML-100 with both synthetic (TPCK or PDTC) or natural (I(kappaB)-alpha) NF-kappaB inhibitors caused apoptotic death. Low doses of TPCK were harmless for CSML100 cells but sensitized them to TNF-induced apoptosis. Death of CSML100 cells in the presence of high concentration TPCK was not accompanied with significant changes in c-myc activity but strongly correlated with rapid decrease in p53 level. Thus, mutual behavior p53 and NF-kappaB represented a unique feature of TPCK-induced apoptosis in CSML-100 adenocarcinoma cells.[1]


  1. High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells. Smirnov, A.S., Ruzov, A.S., Budanov, A.V., Prokhortchouk, A.V., Ivanov, A.V., Prokhortchouk, E.B. Cell Death Differ. (2001) [Pubmed]
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