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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Internal dosimetry for inhalation of hafnium tritide aerosols.

Metal tritides with low dissolution rates may have residence times in the lungs which are considerably longer than the biological half-time normally associated with tritium in body water, resulting in long-term irradiation of the lungs by low energy beta particles and bremsstrahlung X rays. Samples of hafnium tritide were placed in a lung simulant fluid to determine approximate lung dissolution rates. Hafnium hydride samples were analysed for particle size distribution with a scanning electron microscope. Lung simulant data indicated a biological dissolution half-time for hafnium tritide on the order of 10(5) d. Hafnium hydride particle sizes ranged between 2 and 10 microns, corresponding to activity median aerodynamic diameters of 5 to 25 microns. Review of in vitro dissolution data, development of a biokinetic model, and determination of secondary limits for 1 micron AMAD particles are presented and discussed.[1]


  1. Internal dosimetry for inhalation of hafnium tritide aerosols. Inkret, W.C., Schillaci, M.E., Boyce, M.K., Cheng, Y.S., Efurd, D.W., Little, T.T., Miller, G., Musgrave, J.A., Wermer, J.R. Radiation protection dosimetry. (2001) [Pubmed]
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