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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Heme oxygenase ( HO) isoforms in experimental C6 glioma: an immunocytochemical study.

Abstract Because of their potential to regulate tumoural blood flow and interactions with nitric oxide the expression of the type 1 and 2 isoforms of heme oxygenase ( HO-1 and HO-2) were evaluated in implanted C6 striatal gliomas. Immunocytochemistry using antibodies specific for HO-1 and HO-2 were used in 20 C6 glioma tumours. The bulk of the tumour parenchyma and endothelium was negative for both HO isoforms. Isolated, but weak staining for HO-1 was seen in most tumours with focally increased expression in perinecrotic regions. Cells morphologically resembling macrophages stained with both HO-1 and HO-2, but were not numerous. These findings suggest that carbon monoxide, unlike nitric oxide, does not have a major role in regulating tumoural blood flow in this experimental glioma model. These findings once again demonstrate the differences between human malignant glioma and experimental implantation glioma models.[1]


  1. Heme oxygenase (HO) isoforms in experimental C6 glioma: an immunocytochemical study. Lo, S., Bell, H.S., Yamaguchi, S., Wharton, S.B., Whittle, I.R. British journal of neurosurgery. (2001) [Pubmed]
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