- Estradiol decreases the acetylcholine-elicited airway reactivity in ovariectomized rats through an increase in epithelial acetylcholinesterase activity. Degano, B., Prévost, M.C., Berger, P., Molimard, M., Pontier, S., Rami, J., Escamilla, R. Am. J. Respir. Crit. Care Med. (2001)