Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Taupitz, M. et al.

Taupitz, Schnorr, Wagner, Abramjuk, Pilgrimm, Kivelitz, Schink, Hansel, Laub, Hünigen, Hamm,

Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium.

PURPOSE: To evaluate the signal-enhancing characteristics of monomer-coated very small superparamagnetic iron oxide (SPIO) particles used as a blood pool contrast medium for magnetic resonance (MR) angiography in the coronary arteries. MATERIALS AND METHODS: The particles used in this study were coated with citrate as the monomer (VSOP-C91). The particles have a total diameter of 7 nm and show the following relaxivities at 0.47 T: T1, 19 L/mmol. sec(-1); T2, 29 L/mmol. sec(-1). Fifteen cardiac MR examinations were performed at 1.5 T in five pigs. Images were acquired from immediately to 35 minutes (equilibrium phase) after intravenous injection of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles (n = 5 for each substance). RESULTS: Immediately after administration of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles, respectively, increases in the signal-to-noise ratio in blood were 94%, 103%, and 102% and in myocardium were 83%, 83%, and 29% (P <.05, very small SPIO particles versus the low-molecular-weight gadolinium-based compounds). Differences in the blood-to-myocardium contrast-to-noise ratio and visualization of the coronary arteries and their branches were also significant. CONCLUSION: VSOP-C91 significantly improves visualization of the coronary arteries at MR angiography from immediately to 35 minutes after injection.[1]

References

Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium. Taupitz, M., Schnorr, J., Wagner, S., Abramjuk, C., Pilgrimm, H., Kivelitz, D., Schink, T., Hansel, J., Laub, G., Hünigen, H., Hamm, B. Radiology. (2002) [Pubmed]

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