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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand.

The effects of modulation of apoptosis in experimental allergic encephalomyelitis (EAE) in Lewis rats have been investigated using a peptide of the Fas-Ligand protein (FasL-p). The peptide was administered both subcutaneously and intra-cerebro-ventricularly (i.c.v.) after EAE induction. Rats treated subcutaneously with FasL-p showed a worse clinical score as compared to saline treated animals, while i.c.v. treatment with FasL-p did not modify significantly the severity of EAE. Apoptotic lymphomonocytes (identified by TUNEL) infiltrating the brain and the spinal cord were decreased in rats treated i.c.v. with FasL-p. The data suggest that the Fas/Fas-ligand pathway may be modulated by treatments with peptides of Fas-Ligand and that it may be at work within the central nervous system in EAE.[1]

References

  1. Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand. Ciusani, E., Gelati, M., Frigerio, S., Pollo, B., Massa, G., Sacerdote, P., Panerai, A.E., Salmaggi, A. J. Autoimmun. (2001) [Pubmed]
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