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Gene Review

Fas  -  Fas cell surface death receptor

Rattus norvegicus

Synonyms: Apo-1 antigen, Apoptosis-mediating surface antigen FAS, Apt1, FASLG receptor, Tnfrsf6, ...
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Disease relevance of Tnfrsf6


Psychiatry related information on Tnfrsf6


High impact information on Tnfrsf6


Chemical compound and disease context of Tnfrsf6


Biological context of Tnfrsf6


Anatomical context of Tnfrsf6


Associations of Tnfrsf6 with chemical compounds


Physical interactions of Tnfrsf6


Regulatory relationships of Tnfrsf6

  • These data suggest that C5b-9 through PI3K signaling can rescue OLG from Fas-mediated apoptosis by regulating caspase-8 processing [24].
  • In conclusion, we demonstrated the involvement of Fas/FasL system in inducing apoptosis through activation of a caspase-mediated cascade in rat granulosa cells, which is coupled with a decrease in inducible NO synthase expression [18].
  • Over the past few years, a number of experimental evidences suggested the involvement of Fas Ligand (FasL) expressing Sertoli cells to induce apoptosis of Fas bearing germ cells [25].
  • As a result, activated JNK can not only phosphorylate the transcription factor c-Jun and up-regulate Fas L expression but can also phosphorylate 14-3-3 and promote Bax translocation to mitochondria, increase the release of cytochrome c and increase caspase-3 activation [26].
  • The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia [27].

Other interactions of Tnfrsf6

  • In the present study, we examined the possible involvement of the caspase-8 and Fas pathway in OLG apoptosis and the role of C5b-9 in this process [24].
  • Expressions of Fas, Fas ligand, and TNF-alpha type 1 receptor were enhanced in fasting and I/R rats [28].
  • We detected strong immunoreactivity for TNFR1 and Fas in the somatolactotrope cell line GH3 [29].
  • We also show that Fas activation, a molecular event known to play a critical role in anoikis, is not suppressed by TGF-alpha [30].
  • CR suppressed this age-enhanced p53 and Fas receptor mRNA expression, but expression of the other genes was not altered significantly by aging or CR [31].

Analytical, diagnostic and therapeutic context of Tnfrsf6

  • Caspase activity assays and Western blot analysis showed that H9c2 cells treated with Dox for 16 h had marked increase in the levels of caspases-2, -3, -8, -9, -12, Fas, and cleaved poly(ADP ribose) polymerase (PARP) [32].
  • Apoptotic lymphomonocytes (identified by TUNEL) infiltrating the brain and the spinal cord were decreased in rats treated i.c.v. with FasL-p. The data suggest that the Fas/Fas-ligand pathway may be modulated by treatments with peptides of Fas-Ligand and that it may be at work within the central nervous system in EAE [33].
  • Semi-quantitative RT-PCR and Western-blot were used to analyze mRNA and protein expressions of Fas and FasL from freshly isolated HSC [2].
  • The mRNA of Fas and FasL in group C were significantly increased time-dependently compared to those of control group [2].
  • Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants. Influence of Fas-mediated apoptosis [34].


  1. Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension. Ju, K.R., Kim, H.S., Kim, J.H., Lee, N.Y., Park, C.K. Brain Res. (2006) [Pubmed]
  2. The Effects of Interleukin-10 on the Expression of Fas and FasL in Rat Hepatic Stellate Cells. Zhang, L., Wang, X., Zheng, W., Shi, M. Medicinal chemistry (Sh???ariqah, United Arab Emirates) (2006) [Pubmed]
  3. Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. Bonnotte, B., Favre, N., Reveneau, S., Micheau, O., Droin, N., Garrido, C., Fontana, A., Chauffert, B., Solary, E., Martin, F. Cell Death Differ. (1998) [Pubmed]
  4. Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. Stephanou, A., Scarabelli, T.M., Brar, B.K., Nakanishi, Y., Matsumura, M., Knight, R.A., Latchman, D.S. J. Biol. Chem. (2001) [Pubmed]
  5. Fas and Fas ligand expression in Alzheimer's disease. Ferrer, I., Puig, B., Krupinsk, J., Carmona, M., Blanco, R. Acta Neuropathol. (2001) [Pubmed]
  6. Involvement of Fas system and active caspases in apoptotic signalling in testicular germ cells of ethanol-treated rats. Eid, N.A., Shibata, M.A., Ito, Y., Kusakabe, K., Hammad, H., Otsuki, Y. Int. J. Androl. (2002) [Pubmed]
  7. Regulation of Fas and FasL expression on rat Schwann cells. Wohlleben, G., Ibrahim, S.M., Schmidt, J., Toyka, K.V., Hartung, H.P., Gold, R. Glia (2000) [Pubmed]
  8. Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells. Schaub, F.J., Han, D.K., Liles, W.C., Adams, L.D., Coats, S.A., Ramachandran, R.K., Seifert, R.A., Schwartz, S.M., Bowen-Pope, D.F. Nat. Med. (2000) [Pubmed]
  9. Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. Gajate, C., Del Canto-Jañez, E., Acuña, A.U., Amat-Guerri, F., Geijo, E., Santos-Beneit, A.M., Veldman, R.J., Mollinedo, F. J. Exp. Med. (2004) [Pubmed]
  10. Tumor necrosis factor alpha and interleukin 1beta up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection. Houghton, J., Macera-Bloch, L.S., Harrison, L., Kim, K.H., Korah, R.M. Infect. Immun. (2000) [Pubmed]
  11. The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity. Lee, S.Y., Jo, S.K., Cho, W.Y., Kim, H.K., Won, N.H. Transplantation (2004) [Pubmed]
  12. Apoptosis in young rats with adriamycin-induced cardiomyopathy--comparison with pirarubicin, a new anthracycline derivative. Koh, E., Ueda, Y., Nakamura, T., Kobayashi, A., Katsuta, S., Takahashi, H. Pediatr. Res. (2002) [Pubmed]
  13. Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells, a potential pathway of antiliver metastases. Lau, W.Y., Chen, G.G., Lai, P.B., Chun, Y.S., Leung, B.C., Chak, E.C., Lee, J.F., Chui, A.K. J. Surg. Res. (2001) [Pubmed]
  14. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Reinehr, R., Häussinger, D. Gastroenterology (2004) [Pubmed]
  15. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Reinehr, R., Becker, S., Wettstein, M., Häussinger, D. Gastroenterology (2004) [Pubmed]
  16. Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. Peng, Y., Gallagher, S.F., Haines, K., Baksh, K., Murr, M.M. J. Surg. Res. (2006) [Pubmed]
  17. Pneumocystis cell wall beta-glucans induce dendritic cell costimulatory molecule expression and inflammatory activation through a Fas-Fas ligand mechanism. Carmona, E.M., Vassallo, R., Vuk-Pavlovic, Z., Standing, J.E., Kottom, T.J., Limper, A.H. J. Immunol. (2006) [Pubmed]
  18. Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia. Chen, Q., Yano, T., Matsumi, H., Osuga, Y., Yano, N., Xu, J., Wada, O., Koga, K., Fujiwara, T., Kugu, K., Taketani, Y. Endocrinology (2005) [Pubmed]
  19. Suppressing Akt phosphorylation and activating Fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum. Zhao, J., Miao, J., Zhao, B., Zhang, S., Yin, D. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  20. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Jayanthi, S., Deng, X., Ladenheim, B., McCoy, M.T., Cluster, A., Cai, N.S., Cadet, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells. Müschen, M., Warskulat, U., Douillard, P., Gilbert, E., Häussinger, D. Hepatology (1998) [Pubmed]
  22. Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis. Mooney, A., Jobson, T., Bacon, R., Kitamura, M., Savill, J. J. Immunol. (1997) [Pubmed]
  23. Antibody binding to fas ligand attenuates inflammatory cell infiltration and cytokine secretion, leading to reduction of myocardial infarct areas and reperfusion injury. Shiraishi, H., Toyozaki, T., Tsukamoto, Y., Saito, T., Masuda, Y., Hiroshima, K., Ohwada, H., Kobayashi, N., Hiroe, M. Lab. Invest. (2002) [Pubmed]
  24. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., Rus, H. J. Immunol. (2006) [Pubmed]
  25. Ontogenesis and cell specific localization of Fas ligand expression in the rat testis. D'Abrizio, P., Baldini, E., Russo, P.F., Biordi, L., Graziano, F.M., Rucci, N., Properzi, G., Francavilla, S., Ulisse, S. Int. J. Androl. (2004) [Pubmed]
  26. Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Pei, D.S., Wang, X.T., Liu, Y., Sun, Y.F., Guan, Q.H., Wang, W., Yan, J.Z., Zong, Y.Y., Xu, T.L., Zhang, G.Y. Brain (2006) [Pubmed]
  27. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. Boehme, S.A., Lio, F.M., Maciejewski-Lenoir, D., Bacon, K.B., Conlon, P.J. J. Immunol. (2000) [Pubmed]
  28. Apoptotic pathway in the rat small intestinal mucosa is different between fasting and ischemia-reperfusion. Fujise, T., Iwakiri, R., Wu, B., Amemori, S., Kakimoto, T., Yokoyama, F., Sakata, Y., Tsunada, S., Fujimoto, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  29. Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells. Candolfi, M., Jaita, G., Pisera, D., Ferrari, L., Barcia, C., Liu, C., Yu, J., Liu, G., Castro, M.G., Seilicovich, A. J. Endocrinol. (2006) [Pubmed]
  30. Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. Rosen, K., Coll, M.L., Li, A., Filmus, J. J. Biol. Chem. (2001) [Pubmed]
  31. Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver. Ando, K., Higami, Y., Tsuchiya, T., Kanematsu, T., Shimokawa, I. Microsc. Res. Tech. (2002) [Pubmed]
  32. Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. Chua, C.C., Liu, X., Gao, J., Hamdy, R.C., Chua, B.H. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  33. Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand. Ciusani, E., Gelati, M., Frigerio, S., Pollo, B., Massa, G., Sacerdote, P., Panerai, A.E., Salmaggi, A. J. Autoimmun. (2001) [Pubmed]
  34. Tolerance induction ameliorates allograft vasculopathy in rat aortic transplants. Influence of Fas-mediated apoptosis. Akyürek, L.M., Johnsson, C., Lange, D., Georgii-Hemming, P., Larsson, E., Fellström, B.C., Funa, K., Tufveson, G. J. Clin. Invest. (1998) [Pubmed]
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