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Gene Review

Faslg  -  Fas ligand (TNF superfamily, member 6)

Rattus norvegicus

Synonyms: Apt1Lg1, CD95 ligand, CD95-L, Cd95l, Fas antigen ligand, ...
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Disease relevance of Faslg


Psychiatry related information on Faslg


High impact information on Faslg


Chemical compound and disease context of Faslg


Biological context of Faslg


Anatomical context of Faslg


Associations of Faslg with chemical compounds


Physical interactions of Faslg


Regulatory relationships of Faslg


Other interactions of Faslg

  • In the tolerated allografts, however, levels of graft-infiltrating cell apoptosis and CD95L and TNF-alpha expression during the same period of time were dramatically lower [16].
  • Hyperosmolarity, however, sensitized hepatocytes toward CD95L-induced apoptosis, as assessed by annexin V staining and terminal deoxynucleotidyl transferase-mediated X-dUTP nick-end labeling (TUNEL) assay [19].
  • Pretreatment of hepatocytes with ONOO(-) inhibited CD95L- and hyperosmolarity-induced CD95 membrane trafficking and formation of the death-inducing signaling complex, but not epidermal growth factor receptor activation and its association with CD95 [15].
  • We have previously demonstrated by FACS analysis and histochemistry that Fas ligand (FasL) increases on cochlear cell surfaces after immune response or stimulation with gamma-interferon (IFN-gamma) [31].
  • Expression of Fas ligand (FasL), an AP-1 transcriptional target, increased during accelerated cell death [32].

Analytical, diagnostic and therapeutic context of Faslg

  • Recently, conflicting studies have been published concerning the expression and the role of CD95L in allograft rejection and tolerance [16].
  • RESULTS: In the acutely rejected allografts, a peak in the expression of CD95L and TNF-alpha and in the number of apoptotic cells was observed during the first week after transplantation; apoptotic cells were confined to graft-infiltrating cells [16].
  • Real-time RT-PCR revealed an increase in mRNA levels of Fas ligand (Fas-L), a membrane protein related to the TNF family, in cultured microglia following OGD exposure [33].
  • Exogenous Expression of Fas-Ligand or CrmA Prolongs the Survival in Rat Liver Transplantation [18].
  • By Western blot it was determined that the levels of Fas ligand protein were increased in the CD8-depleted group compared with those in control and FK506-treated allograft recipients [34].


  1. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B. Häusler, P., Papoff, G., Eramo, A., Reif, K., Cantrell, D.A., Ruberti, G. Eur. J. Immunol. (1998) [Pubmed]
  2. Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand. Ciusani, E., Gelati, M., Frigerio, S., Pollo, B., Massa, G., Sacerdote, P., Panerai, A.E., Salmaggi, A. J. Autoimmun. (2001) [Pubmed]
  3. Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. Stephanou, A., Scarabelli, T.M., Brar, B.K., Nakanishi, Y., Matsumura, M., Knight, R.A., Latchman, D.S. J. Biol. Chem. (2001) [Pubmed]
  4. The Fas/Fas ligand system is involved in the pathogenesis of autoimmune myocarditis in rats. Ishiyama, S., Hiroe, M., Nishikawa, T., Shimojo, T., Abe, S., Fujisaki, H., Ito, H., Yamakawa, K., Kobayashi, N., Kasajima, T., Marumo, F. J. Immunol. (1998) [Pubmed]
  5. Expression of Fas and Fas ligand after experimental traumatic brain injury in the rat. Beer, R., Franz, G., Schöpf, M., Reindl, M., Zelger, B., Schmutzhard, E., Poewe, W., Kampfl, A. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  6. Fas and Fas ligand expression in Alzheimer's disease. Ferrer, I., Puig, B., Krupinsk, J., Carmona, M., Blanco, R. Acta Neuropathol. (2001) [Pubmed]
  7. Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism. Josien, R., Heslan, M., Soulillou, J.P., Cuturi, M.C. J. Exp. Med. (1997) [Pubmed]
  8. Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M. J. Clin. Invest. (2002) [Pubmed]
  9. A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis. Wildbaum, G., Westermann, J., Maor, G., Karin, N. J. Clin. Invest. (2000) [Pubmed]
  10. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Rodrigues, C.M., Fan, G., Ma, X., Kren, B.T., Steer, C.J. J. Clin. Invest. (1998) [Pubmed]
  11. Apoptosis induced by penta-acetyl geniposide in C6 glioma cells is associated with JNK activation and Fas ligand induction. Peng, C.H., Tseng, T.H., Huang, C.N., Hsu, S.P., Wang, C.J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  12. Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells, a potential pathway of antiliver metastases. Lau, W.Y., Chen, G.G., Lai, P.B., Chun, Y.S., Leung, B.C., Chak, E.C., Lee, J.F., Chui, A.K. J. Surg. Res. (2001) [Pubmed]
  13. Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas/Fas-ligand interactions in experimental autoimmune uveitis. Liversidge, J., Dick, A., Gordon, S. Am. J. Pathol. (2002) [Pubmed]
  14. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Jayanthi, S., Deng, X., Ladenheim, B., McCoy, M.T., Cluster, A., Cai, N.S., Cadet, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes. Reinehr, R., Görg, B., Höngen, A., Häussinger, D. J. Biol. Chem. (2004) [Pubmed]
  16. Fas ligand, tumor necrosis factor-alpha expression, and apoptosis during allograft rejection and tolerance. Josien, R., Müschen, M., Gilbert, E., Douillard, P., Heslan, J.M., Soulillou, J.P., Cuturi, M.C. Transplantation (1998) [Pubmed]
  17. H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP. Facchinetti, F., Furegato, S., Terrazzino, S., Leon, A. J. Neurosci. Res. (2002) [Pubmed]
  18. Exogenous Expression of Fas-Ligand or CrmA Prolongs the Survival in Rat Liver Transplantation. Adachi, K., Fujino, M., Kitazawa, Y., Funeshima-Fuji, N., Takahara, S., Kimura, H., Li, X.K. Transplant. Proc. (2006) [Pubmed]
  19. Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis. Reinehr, R., Graf, D., Fischer, R., Schliess, F., Häussinger, D. Hepatology (2002) [Pubmed]
  20. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. Dermitzaki, E., Tsatsanis, C., Gravanis, A., Margioris, A.N. J. Biol. Chem. (2002) [Pubmed]
  21. Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia. Chen, Q., Yano, T., Matsumi, H., Osuga, Y., Yano, N., Xu, J., Wada, O., Koga, K., Fujiwara, T., Kugu, K., Taketani, Y. Endocrinology (2005) [Pubmed]
  22. Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Kalivendi, S.V., Konorev, E.A., Cunningham, S., Vanamala, S.K., Kaji, E.H., Joseph, J., Kalyanaraman, B. Biochem. J. (2005) [Pubmed]
  23. The role of the Fas/Fas ligand system in estrogen-induced thymic alteration. Mor, G., Muñoz, A., Redlinger, R., Silva, I., Song, J., Lim, C., Kohen, F. Am. J. Reprod. Immunol. (2001) [Pubmed]
  24. Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells. Müschen, M., Warskulat, U., Douillard, P., Gilbert, E., Häussinger, D. Hepatology (1998) [Pubmed]
  25. Antibody binding to fas ligand attenuates inflammatory cell infiltration and cytokine secretion, leading to reduction of myocardial infarct areas and reperfusion injury. Shiraishi, H., Toyozaki, T., Tsukamoto, Y., Saito, T., Masuda, Y., Hiroshima, K., Ohwada, H., Kobayashi, N., Hiroe, M. Lab. Invest. (2002) [Pubmed]
  26. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Zacks, D.N., Zheng, Q.D., Han, Y., Bakhru, R., Miller, J.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  27. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis. Wang, W., Prince, C.Z., Mou, Y., Pollman, M.J. J. Biol. Chem. (2002) [Pubmed]
  28. Ontogenesis and cell specific localization of Fas ligand expression in the rat testis. D'Abrizio, P., Baldini, E., Russo, P.F., Biordi, L., Graziano, F.M., Rucci, N., Properzi, G., Francavilla, S., Ulisse, S. Int. J. Androl. (2004) [Pubmed]
  29. Apoptosis of skeletal muscle on steroid-induced myopathy in rats. Lee, M.C., Wee, G.R., Kim, J.H. J. Nutr. (2005) [Pubmed]
  30. Fas ligand expression following normothermic liver ischemia-reperfusion. Cursio, R., Filippa, N., Miele, C., Colosetti, P., Auberger, P., Van Obberghen, E., Gugenheim, J. J. Surg. Res. (2005) [Pubmed]
  31. Fas ligand expression in the organ of Corti. Bodmer, D., Brors, D., Bodmer, M., Pak, K., Ryan, A.F. Audiol. Neurootol. (2003) [Pubmed]
  32. Activated JNK brings about accelerated apoptosis of Bcl-2-overexpressing C6 glioma cells on treatment with tamoxifen. Moodbidri, M.S., Shirsat, N.V. J. Neurochem. (2005) [Pubmed]
  33. Corticotropin-releasing hormone potentiates neural injury induced by oxygen-glucose deprivation: a possible involvement of microglia. Wang, W., Solc, M., Ji, P., Dow, K.E. Neurosci. Lett. (2004) [Pubmed]
  34. CD8+ cells are not necessary for allograft rejection or the induction of apoptosis in an experimental model of small intestinal transplantation. Krams, S.M., Hayashi, M., Fox, C.K., Villanueva, J.C., Whitmer, K.J., Burns, W., Esquivel, C.O., Martinez, O.M. J. Immunol. (1998) [Pubmed]
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