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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster.

Uptakes of guanine into Malpighian tubules of wild-type Drosophila and the eye color mutants white (w), brown (bw), and pink-peach (pp) have been compared. Tubules for each of these mutants are unable to concentrate guanine intracellularly. The transport of xanthine and riboflavin is also deficient in w tubules. The transport of guanosine, adenine, hypoxanthine, and guanosine monophosphate is similar in wild-type and white Malpighian tubules. These data and other information about these mutants make it likely that these pteridine-deficient eye color mutants do not produce pigments because of the inability to transport a pteridine precursor. This view supports the hypothesis that mutants which lack both pteridine and ommochromes do so because precursors to both classes of pigments share a common transport system.[1]

References

  1. Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster. Sullivan, D.T., Bell, L.A., Paton, D.R., Sullivan, M.C. Biochem. Genet. (1979) [Pubmed]
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