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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus.

We have previously shown that a V3-loop peptide from HIV-1 envelope conjugated to heat-inactivated Brucella abortus (Ba) (V3-Ba) is capable of inducing antibodies that neutralize HIV-1 and cytotoxic T cells (CTL) that kill HIV-1-infected targets, even in mice that lack CD4(+) T cells. In this paper we show that intranasal (i.n.) immunization elicits neutralizing antibodies and IFNgamma-secreting T cells at mucosal surfaces. This approach may protect individuals from HIV-1 infection and reduce transmission from infected individuals to their sexual partners and offspring.[1]

References

  1. Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus. Golding, B., Eller, N., Levy, L., Beining, P., Inman, J., Matthews, N., Scott, D.E., Golding, H. Vaccine (2002) [Pubmed]
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