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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Immunity, Mucosal

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Disease relevance of Immunity, Mucosal


High impact information on Immunity, Mucosal


Chemical compound and disease context of Immunity, Mucosal


Biological context of Immunity, Mucosal


Anatomical context of Immunity, Mucosal


Associations of Immunity, Mucosal with chemical compounds

  • We show here that the development of chronic intestinal inflammation in IL-10-deficient mice requires the function of TNF, indicating that the IL-10/TNF axis regulates mucosal immunity [26].
  • The beneficial effect of arginine administration alone indicates a possible role of nitric oxide and polyamines in this process, and the lactobacilli may execute their action via the same mechanisms or via bacterial antagonism and/or enhancement of systemic and intestinal mucosal immunity [27].
  • We conclude that high oral doses of protein induce both mucosal and systemic unresponsiveness and that use of mucosal adjuvants that induce both parenteral and mucosal immunity may be a better way to assess oral tolerance [28].
  • Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses [29].
  • These data indicate that SIgA can interact with DC not via CD89, but via carbohydrate-recognizing receptors like mannose receptor and suggest that uptake of SIgA-containing immune complexes by immature DC may be a mechanism to modulate mucosal immune responses [30].

Gene context of Immunity, Mucosal


Analytical, diagnostic and therapeutic context of Immunity, Mucosal


  1. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Wright, K., Rooney, N., Feeney, M., Tate, J., Robertson, D., Welham, M., Ward, S. Gastroenterology (2005) [Pubmed]
  2. Mucosal and systemic adjuvant activity of alphavirus replicon particles. Thompson, J.M., Whitmore, A.C., Konopka, J.L., Collier, M.L., Richmond, E.M., Davis, N.L., Staats, H.F., Johnston, R.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Biragyn, A., Belyakov, I.M., Chow, Y.H., Dimitrov, D.S., Berzofsky, J.A., Kwak, L.W. Blood (2002) [Pubmed]
  4. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. McDermott, M.R., Smiley, J.R., Leslie, P., Brais, J., Rudzroga, H.E., Bienenstock, J. J. Virol. (1984) [Pubmed]
  5. An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge. Buge, S.L., Richardson, E., Alipanah, S., Markham, P., Cheng, S., Kalyan, N., Miller, C.J., Lubeck, M., Udem, S., Eldridge, J., Robert-Guroff, M. J. Virol. (1997) [Pubmed]
  6. Origins and functions of B-1 cells with notes on the role of CD5. Berland, R., Wortis, H.H. Annu. Rev. Immunol. (2002) [Pubmed]
  7. FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity. van Egmond, M., van Garderen, E., van Spriel, A.B., Damen, C.A., van Amersfoort, E.S., van Zandbergen, G., van Hattum, J., Kuiper, J., van de Winkel, J.G. Nat. Med. (2000) [Pubmed]
  8. Nitric oxide in mucosal immunity. Green, S.J. Nat. Med. (1995) [Pubmed]
  9. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn. Lencer, W.I., Blumberg, R.S. Trends Cell Biol. (2005) [Pubmed]
  10. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. Coyle, A.J., Lloyd, C., Tian, J., Nguyen, T., Erikkson, C., Wang, L., Ottoson, P., Persson, P., Delaney, T., Lehar, S., Lin, S., Poisson, L., Meisel, C., Kamradt, T., Bjerke, T., Levinson, D., Gutierrez-Ramos, J.C. J. Exp. Med. (1999) [Pubmed]
  11. Systemic and mucosal immune responses after intranasal administration of recombinant Mycobacterium bovis bacillus Calmette-Guérin expressing glutathione S-transferase from Schistosoma haematobium. Kremer, L., Dupré, L., Riveau, G., Capron, A., Locht, C. Infect. Immun. (1998) [Pubmed]
  12. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Fukata, M., Michelsen, K.S., Eri, R., Thomas, L.S., Hu, B., Lukasek, K., Nast, C.C., Lechago, J., Xu, R., Naiki, Y., Soliman, A., Arditi, M., Abreu, M.T. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  13. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Parr, M.B., Kepple, L., McDermott, M.R., Drew, M.D., Bozzola, J.J., Parr, E.L. Lab. Invest. (1994) [Pubmed]
  14. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Kaneko, H., Bednarek, I., Wierzbicki, A., Kiszka, I., Dmochowski, M., Wasik, T.J., Kaneko, Y., Kozbor, D. Virology (2000) [Pubmed]
  15. Intranasal immunization with liposome-formulated Yersinia pestis vaccine enhances mucosal immune responses. Baca-Estrada, M.E., Foldvari, M.M., Snider, M.M., Harding, K.K., Kournikakis, B.B., Babiuk, L.A., Griebel, P.P. Vaccine (2000) [Pubmed]
  16. Modulation of immunity against herpes simplex virus infection via mucosal genetic transfer of plasmid DNA encoding chemokines. Eo, S.K., Lee, S., Chun, S., Rouse, B.T. J. Virol. (2001) [Pubmed]
  17. Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis. Wassef, J.S., Keren, D.F., Mailloux, J.L. Infect. Immun. (1989) [Pubmed]
  18. Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists. Boer, J., Gottschling, D., Schuster, A., Semmrich, M., Holzmann, B., Kessler, H. J. Med. Chem. (2001) [Pubmed]
  19. Cholera toxin B subunit activates arachidonic acid metabolism. Peterson, J.W., Finkelstein, R.A., Cantu, J., Gessell, D.L., Chopra, A.K. Infect. Immun. (1999) [Pubmed]
  20. Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons. Mazzoli, S., Lopalco, L., Salvi, A., Trabattoni, D., Lo Caputo, S., Semplici, F., Biasin, M., Bl, C., Cosma, A., Pastori, C., Meacci, F., Mazzotta, F., Villa, M.L., Siccardi, A.G., Clerici, M. J. Infect. Dis. (1999) [Pubmed]
  21. Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum. Pollok, R.C., Farthing, M.J., Bajaj-Elliott, M., Sanderson, I.R., McDonald, V. Gastroenterology (2001) [Pubmed]
  22. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. Yang, X., Letterio, J.J., Lechleider, R.J., Chen, L., Hayman, R., Gu, H., Roberts, A.B., Deng, C. EMBO J. (1999) [Pubmed]
  23. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Briskin, M., Winsor-Hines, D., Shyjan, A., Cochran, N., Bloom, S., Wilson, J., McEvoy, L.M., Butcher, E.C., Kassam, N., Mackay, C.R., Newman, W., Ringler, D.J. Am. J. Pathol. (1997) [Pubmed]
  24. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. Crellin, N.K., Garcia, R.V., Hadisfar, O., Allan, S.E., Steiner, T.S., Levings, M.K. J. Immunol. (2005) [Pubmed]
  25. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. Gurish, M.F., Humbles, A., Tao, H., Finkelstein, S., Boyce, J.A., Gerard, C., Friend, D.S., Austen, K.F. J. Immunol. (2002) [Pubmed]
  26. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. Kontoyiannis, D., Kotlyarov, A., Carballo, E., Alexopoulou, L., Blackshear, P.J., Gaestel, M., Davis, R., Flavell, R., Kollias, G. EMBO J. (2001) [Pubmed]
  27. Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat. Adawi, D., Kasravi, F.B., Molin, G., Jeppsson, B. Hepatology (1997) [Pubmed]
  28. Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses. Kato, H., Fujihashi, K., Kato, R., Yuki, Y., McGhee, J.R. J. Immunol. (2001) [Pubmed]
  29. Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses. Orson, F.M., Kinsey, B.M., Hua, P.J., Bhogal, B.S., Densmore, C.L., Barry, M.A. J. Immunol. (2000) [Pubmed]
  30. Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation. Heystek, H.C., Moulon, C., Woltman, A.M., Garonne, P., van Kooten, C. J. Immunol. (2002) [Pubmed]
  31. Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity. Boyaka, P.N., Marinaro, M., Jackson, R.J., van Ginkel, F.W., Cormet-Boyaka, E., Kirk, K.L., Kensil, C.R., McGhee, J.R. J. Immunol. (2001) [Pubmed]
  32. Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response. Greenwald, R.J., Lu, P., Halvorson, M.J., Zhou, X., Chen, S., Madden, K.B., Perrin, P.J., Morris, S.C., Finkelman, F.D., Peach, R., Linsley, P.S., Urban, J.F., Gause, W.C. J. Immunol. (1997) [Pubmed]
  33. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. Hieshima, K., Ohtani, H., Shibano, M., Izawa, D., Nakayama, T., Kawasaki, Y., Shiba, F., Shiota, M., Katou, F., Saito, T., Yoshie, O. J. Immunol. (2003) [Pubmed]
  34. Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. Singh, U.P., Singh, S., Ravichandran, P., Taub, D.D., Lillard, J.W. J. Immunol. (2004) [Pubmed]
  35. Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. Zhang, Y., Jamaluddin, M., Wang, S., Tian, B., Garofalo, R.P., Casola, A., Brasier, A.R. J. Virol. (2003) [Pubmed]
  36. Enteral feeding preserves mucosal immunity despite in vivo MAdCAM-1 blockade of lymphocyte homing. Ikeda, S., Kudsk, K.A., Fukatsu, K., Johnson, C.D., Le, T., Reese, S., Zarzaur, B.L. Ann. Surg. (2003) [Pubmed]
  37. Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination. el-Madhun, A.S., Cox, R.J., Søreide, A., Olofsson, J., Haaheim, L.R. J. Infect. Dis. (1998) [Pubmed]
  38. Combined parenteral and oral immunization results in an enhanced mucosal immunoglobulin A response to Shigella flexneri. Keren, D.F., McDonald, R.A., Carey, J.L. Infect. Immun. (1988) [Pubmed]
  39. A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Lambert, J.S., Keefer, M., Mulligan, M.J., Schwartz, D., Mestecky, J., Weinhold, K., Smith, C., Hsieh, R., Moldoveanu, Z., Fast, P., Forrest, B., Koff, W. Vaccine (2001) [Pubmed]
  40. Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant Hepatitis B antigen administered intranasally. Jaganathan, K.S., Vyas, S.P. Vaccine (2006) [Pubmed]
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