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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sexual Partners

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Disease relevance of Sexual Partners

  • The relative risk of tubal infertility associated with barrier contraceptive use or oral contraceptive use was calculated using multivariate logistic regression to control for confounding by region, age, religion, education, smoking, number of sexual partners, time since menarche, and use of other contraceptive methods [1].
  • Baseline positivity was associated with Aboriginal ancestry, older age, greater number of years injecting drugs, recent incarceration, sex trade work, more than 100 lifetime sexual partners, a previous sexually transmitted disease, living in the IDU epicenter, and injection more than once per day of heroin, cocaine, and speedball [2].
  • The response observed in the antibody- and antigen-negative sexual partners and in some of the zidovudine-treated patients implies that at least some epitopes on HIV envelope are immunogenic in man [3].
  • HIV-1 subtypes were determined by phylogenetic analysis of env V3 sequences and correlated with sociodemographic characteristics of the subjects and their sexual partners [4].
  • Hepatitis B e antigen and abnormal serum glutamic pyruvic transaminase levels were detected more frequently in sexual partners who were HBsAg carriers (29.6% and 48.1%, respectively) than in comparable control partners (2.6% and 5.4%, respectively) [5].

Psychiatry related information on Sexual Partners


High impact information on Sexual Partners

  • All of the women were provided with latex condoms and were instructed to have their male sexual partners use them [11].
  • IMPLICATIONS: Men who report multiple sexual partners or who are carriers of HPV DNA may be vectors of high-risk HPV types and may place their wives at high risk of developing cervical cancer [12].
  • However, infection was significantly more frequent among spouses and sexual partners of carriers who had either HBeAg (P less than 0.001) or elevated DNA polymerase activity (P less than 0.001) [13].
  • This ability highlights the GAT domain as a hub for interactions with multiple partners in trafficking [14].
  • These results suggest that the cation channel trp2 is required in the VNO to detect male-specific pheromones that elicit aggressive behaviors and dictate the choice of sexual partners [15].

Chemical compound and disease context of Sexual Partners


Biological context of Sexual Partners


Anatomical context of Sexual Partners

  • T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners [3].
  • This case and previously published laboratory data suggest that intravaginal nonoxynol-9 deserves further study as a treatment for resistant trichomoniasis, though trichomonal coinfection of the patient's urethra, Skene glands, and sexual partner would not likely be resolved by such therapy [26].
  • The recurrence rate after treatment in the couples in which the man harbored yeast (oral cavity, penile coronal sulcus, seminal fluid) was lower (15.8% vs. 44.8%, P = .0019) than that recorded in the couples without sexual partner involvement [27].
  • For the seronegative homosexual men, a low CD4/8 ratio as a result of an increased CD8 cell count was present in 12 of 60, and was associated with numerous sexual partners and semen culture positive for cytomegalovirus [28].

Associations of Sexual Partners with chemical compounds

  • Two integrin subunits, the alpha subunit alpha v, and the beta subunit beta 1, could pose special problems in regulation because of their capacity to associate with multiple partners [29].
  • Self-reported intravenous cocaine use fell from 33 to 15% over 5 years, shooting gallery use fell from 19 to 6%, and the proportion with five or more sexual partners fell from 25 to 10% [30].
  • Risk factors for seroconversion were five or more sexual partners per year [hazard ratio (HR) = 2.6; P = 0.02], use of shooting gallery ever (HR = 2.9; P = 0.02), and less than 1 year (lifetime) in methadone maintenance (HR = 2.7; P = 0.02) [30].
  • This study was designed to discover whether transmission of oral isolates could occur between sexual partners and thereby explain fluconazole resistance in patients never treated with the drug [31].
  • CONCLUSION: Substance use before or during sex was not associated with risk with HIV-negative partners, suggesting that disclosure by HIV-negative sexual partners of HIV-positive men may be important [32].

Gene context of Sexual Partners

  • The strict receptor binding specificity of CCL20 is exceptional; other chemokines and their receptors bind promiscuously with multiple partners [33].
  • Cox regression revealed that elevated IgA levels, low CD4 counts, elevated immune complexes, two or more symptoms, and more than 20 male sexual partners in high-risk areas in the 5 years prior to enrollment were independent predictors of progression to AIDS over the subsequent 5 years [34].
  • Patients infected with TRNG reported significantly more lifetime sexual partners (P less than .05) but otherwise resembled patients infected with antibiotic-sensitive gonococci [35].
  • No correlation was found between age and number of sexual partners, with serum positivity to the E2, E6, and E7 papillomavirus proteins [36].
  • Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners [37].

Analytical, diagnostic and therapeutic context of Sexual Partners


  1. The relationship of tubal infertility to barrier method and oral contraceptive use. Cramer, D.W., Goldman, M.B., Schiff, I., Belisle, S., Albrecht, B., Stadel, B., Gibson, M., Wilson, E., Stillman, R., Thompson, I. JAMA (1987) [Pubmed]
  2. Opportunities for prevention: hepatitis C prevalence and incidence in a cohort of young injection drug users. Miller, C.L., Johnston, C., Spittal, P.M., Li, K., Laliberté, N., Montaner, J.S., Schechter, M.T. Hepatology (2002) [Pubmed]
  3. T-cell response towards HIV in infected individuals with and without zidovudine therapy, and in HIV-exposed sexual partners. Ranki, A., Mattinen, S., Yarchoan, R., Broder, S., Ghrayeb, J., Lähdevirta, J., Krohn, K. AIDS (1989) [Pubmed]
  4. The impact of immigration on env HIV-1 subtype distribution among heterosexuals in the Netherlands: influx of subtype B and non-B strains. Op de Coul, E.L., Coutinho, R.A., van der Schoot, A., van Doornum, G.J., Lukashov, V.V., Goudsmit, J., Cornelissen, M. AIDS (2001) [Pubmed]
  5. Source of infection due to hepatitis B virus in Greece. Papaevangelou, G., Roumeliotou-Karayannîs, A., Tassopoulos, N., Kolaitis, N., Stathopoulou, P. J. Infect. Dis. (1983) [Pubmed]
  6. Relation of female infertility to consumption of caffeinated beverages. Grodstein, F., Goldman, M.B., Ryan, L., Cramer, D.W. Am. J. Epidemiol. (1993) [Pubmed]
  7. Intimate relationship characteristics associated with condom use among drug users and their sex partners: a multilevel analysis. Sherman, S.G., Latkin, C.A. Drug and alcohol dependence. (2001) [Pubmed]
  8. Psychosocial determinants for sexual partner referral in Uganda: qualitative results. Nuwaha, F., Faxelid, E., Neema, S., Eriksson, C., Höjer, B. International journal of STD & AIDS. (2000) [Pubmed]
  9. Early life sexual abuse as a risk factor for crack cocaine use in a sample of community-recruited women at high risk for illicit drug use. Freeman, R.C., Collier, K., Parillo, K.M. The American journal of drug and alcohol abuse. (2002) [Pubmed]
  10. High risk health behaviours among adult Jamaicans. Figueroa, J.P., Ward, E., Walters, C., Ashley, D.E., Wilks, R.J. The West Indian medical journal. (2005) [Pubmed]
  11. A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases. Roddy, R.E., Zekeng, L., Ryan, K.A., Tamoufé, U., Weir, S.S., Wong, E.L. N. Engl. J. Med. (1998) [Pubmed]
  12. Male sexual behavior and human papillomavirus DNA: key risk factors for cervical cancer in Spain. Bosch, F.X., Castellsagué, X., Muñoz, N., de Sanjosé, S., Ghaffari, A.M., González, L.C., Gili, M., Izarzugaza, I., Viladiu, P., Navarro, C., Vergara, A., Ascunce, N., Guerrero, E., Shah, K.V. J. Natl. Cancer Inst. (1996) [Pubmed]
  13. Hepatitis B e antigen, DNA polymerase activity, and infection of household contacts with hepatitis B virus. Perrillo, R.P., Gelb, L., Campbell, C., Wellinghoff, W., Ellis, F.R., Overby, L., Aach, R.D. Gastroenterology (1979) [Pubmed]
  14. Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Prag, G., Lee, S., Mattera, R., Arighi, C.N., Beach, B.M., Bonifacino, J.S., Hurley, J.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. Altered sexual and social behaviors in trp2 mutant mice. Leypold, B.G., Yu, C.R., Leinders-Zufall, T., Kim, M.M., Zufall, F., Axel, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Is HIV infection associated with an increase in the prevalence of cervical neoplasia? Smith, J.R., Kitchen, V.S., Botcherby, M., Hepburn, M., Wells, C., Gor, D., Forster, S.M., Harris, J.R., Steer, P., Mason, P. British journal of obstetrics and gynaecology. (1993) [Pubmed]
  17. Alcohol consumption increases attractiveness ratings of opposite-sex faces: a possible third route to risky sex. Jones, B.T., Jones, B.C., Thomas, A.P., Piper, J. Addiction (2003) [Pubmed]
  18. Differentiation of Gardnerella vaginalis, Candida albicans, and Trichomonas vaginalis infections of the vagina. Reed, B.D., Huck, W., Zazove, P. The Journal of family practice. (1989) [Pubmed]
  19. Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study. Lassus, A., Paavonen, J., Kousa, M., Saikku, P. Acta Derm. Venereol. (1979) [Pubmed]
  20. Sexual and reproductive life events in relation to duration of oral contraceptive use. Lidegaard, O., Helm, P. Contraception. (1988) [Pubmed]
  21. High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial. Brody, S. Biol. Psychiatry (2002) [Pubmed]
  22. Prevalence and correlates of herpes simplex virus type 2 infection in a population-based survey of young women in low-income neighborhoods of Northern California. The Young Women's Survey Team. Buchacz, K., McFarland, W., Hernandez, M., Klausner, J.D., Page-Shafer, K., Padian, N., Molitor, F., Ruiz, J.D., Bolan, G., Morrow, S., Katz, M.H. Sexually transmitted diseases. (2000) [Pubmed]
  23. Sexual behavior in lesbian and heterosexual women: relations with menstrual cycle phase and partner availability. Burleson, M.H., Trevathan, W.R., Gregory, W.L. Psychoneuroendocrinology (2002) [Pubmed]
  24. Acute hepatitis B in Western Sweden--genotypes and transmission routes. Lindh, M., Horal, P., Norkrans, G. Infection (2000) [Pubmed]
  25. Comparing gay and bisexual men on sexual behavior, condom use, and psychosocial variables related to HIV/AIDS. Stokes, J.P., Vanable, P., McKirnan, D.J. Archives of sexual behavior. (1997) [Pubmed]
  26. Resolution of resistant vaginal trichomoniasis associated with the use of intravaginal nonoxynol-9. Livengood, C.H., Lossick, J.G. Obstetrics and gynecology. (1991) [Pubmed]
  27. Recurrent vaginal candidiasis. Results of a cohort study of sexual transmission and intestinal reservoir. Spinillo, A., Carratta, L., Pizzoli, G., Lombardi, G., Cavanna, C., Michelone, G., Guaschino, S. The Journal of reproductive medicine. (1992) [Pubmed]
  28. Immunological abnormalities in asymptomatic homosexual men: correlation with antibody to HTLV-III and sequential changes over two years. Frazer, I.H., Mackay, I.R., Crapper, R.M., Jones, B., Gust, I.D., Sarngadharan, M.G., Campbell, D.C., Ungar, B. Q. J. Med. (1986) [Pubmed]
  29. Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. Sheppard, D., Cohen, D.S., Wang, A., Busk, M. J. Biol. Chem. (1992) [Pubmed]
  30. HIV seroconversion in intravenous drug users in San Francisco, 1985-1990. Moss, A.R., Vranizan, K., Gorter, R., Bacchetti, P., Watters, J., Osmond, D. AIDS (1994) [Pubmed]
  31. Oral transmission of Candida albicans between partners in HIV-infected couples could contribute to dissemination of fluconazole-resistant isolates. Dromer, F., Improvisi, L., Dupont, B., Eliaszewicz, M., Pialoux, G., Fournier, S., Feuillie, V. AIDS (1997) [Pubmed]
  32. Illicit substance use, sexual risk, and HIV-positive gay and bisexual men: differences by serostatus of casual partners. Purcell, D.W., Moss, S., Remien, R.H., Woods, W.J., Parsons, J.T. AIDS (2005) [Pubmed]
  33. NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6. Pérez-Cañadillas, J.M., Zaballos, A., Gutiérrez, J., Varona, R., Roncal, F., Albar, J.P., Márquez, G., Bruix, M. J. Biol. Chem. (2001) [Pubmed]
  34. Progression to AIDS and predictors of AIDS in seroprevalent and seroincident cohorts of homosexual men. Schechter, M.T., Craib, K.J., Le, T.N., Willoughby, B., Douglas, B., Sestak, P., Montaner, J.S., Weaver, M.S., Elmslie, K.D., O'Shaughnessy, M.V. AIDS (1989) [Pubmed]
  35. Determinants of emergence of antibiotic-resistant Neisseria gonorrhoeae. Hook, E.W., Brady, W.E., Reichart, C.A., Upchurch, D.M., Sherman, L.A., Wasserheit, J.N. J. Infect. Dis. (1989) [Pubmed]
  36. Antibodies against human papillomavirus (HPV) type 16 and 18 E2, E6 and E7 proteins in sera: correlation with presence of papillomavirus DNA. Rosales, R., López-Contreras, M., Cortes, R.R. J. Med. Virol. (2001) [Pubmed]
  37. The sum is greater than the FGFR1 partner. Braun, B.S., Shannon, K. Cancer Cell (2004) [Pubmed]
  38. Hepatitis C virus among self declared non-injecting sexual partners of injecting drug users. Roy, K.M., Goldberg, D.J., Hutchinson, S., Cameron, S.O., Wilson, K., MacDonald, L. J. Med. Virol. (2004) [Pubmed]
  39. Effects of neonatal castration and testosterone treatment on sexual partner preference in the ferret. Stockman, E.R., Callaghan, R.S., Baum, M.J. Physiol. Behav. (1985) [Pubmed]
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