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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L.

The acute LD50s of ferulenol were determined in albino mice by single po or ip as 2,100 and 319 mg/kg bw, respectively. Ferulenol had a higher LD50 compared to warfarin and thus has a lower acute toxicity. Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages similar to those described in ferulosys and anti-vitamin K experimental poisonings. Male mice were more sensitive to intoxication by ferulenol than were females.[1]

References

  1. Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L. Fraigui, O., Lamnaouer, D., Faouzi, M.Y. Veterinary and human toxicology. (2002) [Pubmed]
 
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