Disease relevance of Ferulenol

• Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages similar to those described in ferulosys and anti-vitamin K experimental poisonings [1].

High impact information on Ferulenol

• Remarkably, ferulenol exerts a dose-dependent cytotoxic activity against various human tumor cell lines [2].
• Ferulenol stimulates tubulin polymerization in vitro, and inhibits the binding of radiolabeled colchicine to tubulin [2].
• Marked reduction of vitamin K-dependent coagulation factors and prolongation of prothrombin time and activated partial thromboplastin time were consistent with presence of ferulenol, a toxic coumarinic factor in the plant [3].
• Dynamics of plasma ferulenol concentration and its effect on the vitamin K-dependent coagulation factors, prothrombin time (PT), and activated partial thromboplastin time (APTT) were determined in 4 sheep intoxicated individually with 600 g of powdered Ferula communis variety brevifolia (FCb) given in 8 doses at intervals of 6 hours [4].
• The acute LD50s of ferulenol were determined in albino mice by single po or ip as 2,100 and 319 mg/kg bw, respectively [1].

Biological context of Ferulenol

• Among the constituents of the toxic variety, both ferulenol, a 4-hydroxycoumarin derivative, and ferprenin, a pyrane (3,2-c) coumarin derivative, affected blood clotting [5].

References