Disease relevance of Ferula

• Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin [1].
• Also in this study the effect of the other coumarins extracted from Ferula persica roots were evaluated for depigmentation of Serratia marcescens . None of these compounds appeared to have a bleaching effect against a test strain at certain concentrations [2].

Psychiatry related information on Ferula

• Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice [3].

High impact information on Ferula

• We have investigated the ionophoretic and apoptotic properties of the daucane sesquiterpene ferutinin and three related compounds, ferutidin, 2-alpha-hydroxyferutidin and teferin, all isolated from various species of plants from the genus Ferula [4].
• Also, asafoetida significantly restored the level of antioxidant system, depleted by MNU-treatment [5].
• Asafoetida treatment significantly reduced (p < 0.05) the levels of cytochrome P450 and b5 [5].
• There was an enhancement in the activities of glutathione S-transferase (p < 0.05-0.005), DT-diaphorase (p < 0.05-0.01), superoxide dismutase (p < 0.01-0.005) and catalase (p < 0.05-0.005) and in the level of reduced glutathione (p < 0.05-0.005), followed by asafoetida treatment [5].
• In this study we investigated biological activity of ferulenol, a prenylated 4-hydroxycoumarin from Ferula communis [6].

Biological context of Ferula

• The strengthening of antioxidant system by the lower and higher doses of asafoetida in the presence and absence of MNU was further substantiated by a significant inhibition (p < 0.005) in lipid peroxidation as measured by thiobarbituric acid-reactive substances (TBARS) in the liver of rat [5].

Anatomical context of Ferula

• Exposure of the precontracted ileum by acetylcholine (10 microM) to Ferula asafoetida gum extract caused relaxation in a concentration-dependent manner [7].
• It might be concluded that the relaxant compounds in Ferula asafoetida gum extract interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilisation of calcium ions required for smooth muscle contraction non-specificly [7].

Associations of Ferula with chemical compounds

• Genotoxicity of garlic, turmeric and asafoetida in mice [8].
• Contraceptive efficacy and hormonal profile of ferujol: a new coumarin from Ferula jaeschkeana [9].
• On the other hand, asafoetida at 1.5% level failed to reduce the serum cholesterol levels in the cholesterol-fed rats [10].
• Lapidin, a bicyclic sesquiterpene from Ferula linkii Webb, has been evaluated for antinociceptive, anti-inflammatory, and antipyretic activities in mice and rats [11].
• Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats [5].

Gene context of Ferula

• We conclude that asafoetida is a potent antioxidant and can afford protection against free radical mediated diseases such as carcinogenesis [12].
• The pretreament of animals with asafoetida recovered the antioxidant level and reversed the induced ODC activity and DNA synthesis significantly (p<0.01) [12].
• In the current investigation, we report the antioxidant and anticarcinogenic potential of asafoetida (Ferula narthex) in swiss albino mice [12].

References