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Disease relevance of Ferula

  • Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin [1].
  • Also in this study the effect of the other coumarins extracted from Ferula persica roots were evaluated for depigmentation of Serratia marcescens . None of these compounds appeared to have a bleaching effect against a test strain at certain concentrations [2].

Psychiatry related information on Ferula


High impact information on Ferula

  • We have investigated the ionophoretic and apoptotic properties of the daucane sesquiterpene ferutinin and three related compounds, ferutidin, 2-alpha-hydroxyferutidin and teferin, all isolated from various species of plants from the genus Ferula [4].
  • Also, asafoetida significantly restored the level of antioxidant system, depleted by MNU-treatment [5].
  • Asafoetida treatment significantly reduced (p < 0.05) the levels of cytochrome P450 and b5 [5].
  • There was an enhancement in the activities of glutathione S-transferase (p < 0.05-0.005), DT-diaphorase (p < 0.05-0.01), superoxide dismutase (p < 0.01-0.005) and catalase (p < 0.05-0.005) and in the level of reduced glutathione (p < 0.05-0.005), followed by asafoetida treatment [5].
  • In this study we investigated biological activity of ferulenol, a prenylated 4-hydroxycoumarin from Ferula communis [6].

Biological context of Ferula

  • The strengthening of antioxidant system by the lower and higher doses of asafoetida in the presence and absence of MNU was further substantiated by a significant inhibition (p < 0.005) in lipid peroxidation as measured by thiobarbituric acid-reactive substances (TBARS) in the liver of rat [5].

Anatomical context of Ferula

  • Exposure of the precontracted ileum by acetylcholine (10 microM) to Ferula asafoetida gum extract caused relaxation in a concentration-dependent manner [7].
  • It might be concluded that the relaxant compounds in Ferula asafoetida gum extract interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilisation of calcium ions required for smooth muscle contraction non-specificly [7].

Associations of Ferula with chemical compounds


Gene context of Ferula

  • We conclude that asafoetida is a potent antioxidant and can afford protection against free radical mediated diseases such as carcinogenesis [12].
  • The pretreament of animals with asafoetida recovered the antioxidant level and reversed the induced ODC activity and DNA synthesis significantly (p<0.01) [12].
  • In the current investigation, we report the antioxidant and anticarcinogenic potential of asafoetida (Ferula narthex) in swiss albino mice [12].


  1. Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin. Fraigui, O., Lamnaouer, D., Faouzi, M.Y., Cherrah, Y., Tijjane, M. Veterinary and human toxicology. (2001) [Pubmed]
  2. Bleaching of Serratia marcescens by some coumarins: a spectrophotometric study. Shahverdi, A.R., Mirjani, R., Amin, G., Shafiee, A., Iranshahi, M. J. Basic Microbiol. (2005) [Pubmed]
  3. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. Sayyah, M., Mandgary, A., Kamalinejad, M. Journal of ethnopharmacology. (2002) [Pubmed]
  4. Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line. Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M., Fiebich, B.L., Muñoz, E. Biochem. Pharmacol. (2004) [Pubmed]
  5. Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. Mallikarjuna, G.U., Dhanalakshmi, S., Raisuddin, S., Rao, A.R. Breast Cancer Res. Treat. (2003) [Pubmed]
  6. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol. Bocca, C., Gabriel, L., Bozzo, F., Miglietta, A. Planta Med. (2002) [Pubmed]
  7. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. Fatehi, M., Farifteh, F., Fatehi-Hassanabad, Z. Journal of ethnopharmacology. (2004) [Pubmed]
  8. Genotoxicity of garlic, turmeric and asafoetida in mice. Abraham, S.K., Kesavan, P.C. Mutat. Res. (1984) [Pubmed]
  9. Contraceptive efficacy and hormonal profile of ferujol: a new coumarin from Ferula jaeschkeana. Singh, M.M., Gupta, D.N., Wadhwa, V., Jain, G.K., Khanna, N.M., Kamboj, V.P. Planta Med. (1985) [Pubmed]
  10. Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol. Kamanna, V.S., Chandrasekhara, N. Lipids (1982) [Pubmed]
  11. Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene. Valencia, E., Feria, M., Díaz, J.G., González, A., Bermejo, J. Planta Med. (1994) [Pubmed]
  12. Asafoetida inhibits early events of carcinogenesis: a chemopreventive study. Saleem, M., Alam, A., Sultana, S. Life Sci. (2001) [Pubmed]
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