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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Distribution of metabotropic glutamate receptors in the superior colliculus of the adult rat, ferret and cat.

The distribution of different metabotropic glutamate receptors (mGluRs 1a, 1b, 1c, 2/3, 4 and 5) has been compared in the superior colliculus of the rat, cat and ferret using immunohistochemical techniques and light microscopy. We found that although there are differences in labelling patterns between the species, there are also substantial similarities. In general, there was only light staining for the various mGluR1 splice variants, whereas labelling for the other Group I receptor, mGluR5, was heavier and with a pattern which suggested that at least some label arose from retinal afferents to the superficial superior colliculus. A further consistent feature in all species was labelling of astrocytes in the optic nerve/optic tract, superficial superior colliculus and brain at the collicular level with the antibody directed towards the Group II receptors, mGluR2 and mGluR3. Staining for the Group III receptor, mGluR4, was dense in the superficial superior colliculus in all species, with characteristics suggesting nerve fibre staining. mGluR4 staining was seen in the cat optic nerve/optic tract. One source of mGluR4 staining in the superior colliculus may thus be retinal axons, although other sources cannot be entirely excluded. These results demonstrate that distributions of mGluRs in these species have significant similarities but also some differences, suggesting that within the superior colliculus there may be some preservation of functional roles for some of the different receptor types. This is particularly so for the Group II and Group III receptors, which appear to have specific and distinct roles in the modulation of visual responses.[1]


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