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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dopamine receptor-coupling defect in hypertension.

Dopamine synthesized in non-neural tissues, eg, renal proximal tubule, functions in an autocrine or paracrine manner. The effects of dopamine are transduced by two classes of receptors (D1- and D2-like) that belong to the superfamily of G protein-coupled receptors. In genetic hypertension, the D1 receptor, a member of the D1-like receptor family, is uncoupled from its G protein complex, resulting in a decreased ability to regulate renal sodium transport. The impaired D1 receptor/G protein coupling in renal proximal tubules in genetic hypertension is secondary to abnormal phosphorylation and desensitization of the D1 receptor caused by activating single nucleotide polymorphisms of a G protein-coupled receptor kinase, GRK type 4.[1]


  1. Dopamine receptor-coupling defect in hypertension. Jose, P.A., Eisner, G.M., Felder, R.A. Current hypertension reports. (2002) [Pubmed]
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