Glucocorticoids in adipocytes stimulate visceral obesity.
The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids. When over-expressed in adipose tissue, this enzyme was shown to promote increased visceral adipose levels. The resulting visceral obesity was associated with insulin-resistant diabetes and dyslipidemia. Increased adipocyte 11beta HSD-1 is a possible cause of visceral obesity in humans.[1]References
- Glucocorticoids in adipocytes stimulate visceral obesity. Wolf, G. Nutr. Rev. (2002) [Pubmed]
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