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Chemical Compound Review

Hydroxysteroid     10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12,14,15...

Synonyms: AGN-PC-006SNI, NSC-36919, SureCN13979892, AC1L5UIH, NSC36919, ...
 
 
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Disease relevance of C02159

 

Psychiatry related information on C02159

  • It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease [6].
  • This suggests that weight gain in the patient with anorexia nervosa could be associated with increased activity in the adrenal 17,20-lyase enzymes and a decrease in the activity of the 3-beta hydroxysteroid dehydrogenase [7].
 

High impact information on C02159

  • The predicted amino acid sequence of the Ts2 protein shows significant similarity to short-chain alcohol dehydrogenases, particularly hydroxysteroid dehydrogenases [8].
  • Molecular endocrinology of hydroxysteroid dehydrogenases [9].
  • Our results suggest that bile acids did not reflux into the esophagus of patients with gastroesophageal reflux disease whom we studied and caution must be exercised in the use of enzymatic assay for bile acids in postprandial gastrointestinal fluids, as the commonly used hydroxysteroid dehydrogenase assay is not specific for bile acids alone [10].
  • CRH was biologically active on human sebocytes: it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10(-7) M and up-regulated mRNA levels of 3 beta- hydroxysteroid dehydrogenase/Delta(5-4) isomerase, although it did not affect cell viability, cell proliferation, or IL-1 beta-induced IL-8 release [11].
  • That the TAM-induced PR was indeed functional was evident from (a) increased activities of the progestin-sensitive enzyme, 17 beta-estradiol hydroxysteroid dehydrogenase and (b) histological appearance of subnuclear vacuolization in these tumors after progestin administration [12].
 

Chemical compound and disease context of C02159

 

Biological context of C02159

 

Anatomical context of C02159

 

Associations of C02159 with other chemical compounds

 

Gene context of C02159

 

Analytical, diagnostic and therapeutic context of C02159

References

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