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Chemical Compound Review

Hydroxysteroid     10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12,14,15...

Synonyms: AGN-PC-006SNI, NSC-36919, SureCN13979892, AC1L5UIH, NSC36919, ...
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Disease relevance of C02159


Psychiatry related information on C02159

  • It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease [6].
  • This suggests that weight gain in the patient with anorexia nervosa could be associated with increased activity in the adrenal 17,20-lyase enzymes and a decrease in the activity of the 3-beta hydroxysteroid dehydrogenase [7].

High impact information on C02159

  • The predicted amino acid sequence of the Ts2 protein shows significant similarity to short-chain alcohol dehydrogenases, particularly hydroxysteroid dehydrogenases [8].
  • Molecular endocrinology of hydroxysteroid dehydrogenases [9].
  • Our results suggest that bile acids did not reflux into the esophagus of patients with gastroesophageal reflux disease whom we studied and caution must be exercised in the use of enzymatic assay for bile acids in postprandial gastrointestinal fluids, as the commonly used hydroxysteroid dehydrogenase assay is not specific for bile acids alone [10].
  • CRH was biologically active on human sebocytes: it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10(-7) M and up-regulated mRNA levels of 3 beta- hydroxysteroid dehydrogenase/Delta(5-4) isomerase, although it did not affect cell viability, cell proliferation, or IL-1 beta-induced IL-8 release [11].
  • That the TAM-induced PR was indeed functional was evident from (a) increased activities of the progestin-sensitive enzyme, 17 beta-estradiol hydroxysteroid dehydrogenase and (b) histological appearance of subnuclear vacuolization in these tumors after progestin administration [12].

Chemical compound and disease context of C02159


Biological context of C02159


Anatomical context of C02159


Associations of C02159 with other chemical compounds


Gene context of C02159


Analytical, diagnostic and therapeutic context of C02159


  1. Evidence by molecular profiling for a placental origin of infantile hemangioma. Barnés, C.M., Huang, S., Kaipainen, A., Sanoudou, D., Chen, E.J., Eichler, G.S., Guo, Y., Yu, Y., Ingber, D.E., Mulliken, J.B., Beggs, A.H., Folkman, J., Fishman, S.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Maternal hypertension and progeny blood pressure: role of aldosterone and 11beta-HSD. Gomez-Sanchez, E.P., Gomez-Sanchez, C.E. Hypertension (1999) [Pubmed]
  3. Effect of retinoic acid and palm oil carotenoids on oestrone sulphatase and oestradiol-17beta hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines. Ng, J.H., Nesaretnam, K., Reimann, K., Lai, L.C. Int. J. Cancer (2000) [Pubmed]
  4. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Lesage, J., Blondeau, B., Grino, M., Bréant, B., Dupouy, J.P. Endocrinology (2001) [Pubmed]
  5. Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis. Falany, J.L., Greer, H., Kovacs, T., Sorscher, E.J., Falany, C.N. Biochem. J. (2002) [Pubmed]
  6. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Yan, S.D., Fu, J., Soto, C., Chen, X., Zhu, H., Al-Mohanna, F., Collison, K., Zhu, A., Stern, E., Saido, T., Tohyama, M., Ogawa, S., Roher, A., Stern, D. Nature (1997) [Pubmed]
  7. Anorexia nervosa and the adrenal: the effect of weight gain. Treasure, J., Wheeler, M.J., Safieh, B., Russell, G.F. Journal of psychiatric research. (1985) [Pubmed]
  8. Sex determination gene TASSELSEED2 of maize encodes a short-chain alcohol dehydrogenase required for stage-specific floral organ abortion. DeLong, A., Calderon-Urrea, A., Dellaporta, S.L. Cell (1993) [Pubmed]
  9. Molecular endocrinology of hydroxysteroid dehydrogenases. Penning, T.M. Endocr. Rev. (1997) [Pubmed]
  10. Do bile acids reflux into the esophagus? A study in normal subjects and patients with gastroesophageal reflux disease. Mittal, R.K., Reuben, A., Whitney, J.O., McCallum, R.W. Gastroenterology (1987) [Pubmed]
  11. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Zouboulis, C.C., Seltmann, H., Hiroi, N., Chen, W., Young, M., Oeff, M., Scherbaum, W.A., Orfanos, C.E., McCann, S.M., Bornstein, S.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice. Satyaswaroop, P.G., Zaino, R.J., Mortel, R. Cancer Res. (1984) [Pubmed]
  13. Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia as a distinct subtype of Cushing's syndrome. Enzyme histochemical and ultrastructural study of four cases with a review of the literature. Aiba, M., Hirayama, A., Iri, H., Ito, Y., Fujimoto, Y., Mabuchi, G., Murai, M., Tazaki, H., Maruyama, H., Saruta, T. Am. J. Clin. Pathol. (1991) [Pubmed]
  14. Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. Bulun, S.E., Zeitoun, K.M., Takayama, K., Sasano, H. J. Mol. Endocrinol. (2000) [Pubmed]
  15. Insulin-like growth factor type I and insulin-like growth factor type II stimulate oestradiol-17 beta hydroxysteroid dehydrogenase (reductive) activity in breast cancer cells. Singh, A., Reed, M.J. J. Endocrinol. (1991) [Pubmed]
  16. Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study. Haider, S.G., Pickartz, H., Freundl, G., Passia, D. Acta anatomica. (1985) [Pubmed]
  17. Enzymatic transformation of morphine by hydroxysteroid dehydrogenase from Pseudomonas testosteroni. Liras, P., Kasparian, S.S., Umbreit, W.W. Applied microbiology. (1975) [Pubmed]
  18. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Susztak, K., Böttinger, E., Novetsky, A., Liang, D., Zhu, Y., Ciccone, E., Wu, D., Dunn, S., McCue, P., Sharma, K. Diabetes (2004) [Pubmed]
  19. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. Song, C.S., Echchgadda, I., Baek, B.S., Ahn, S.C., Oh, T., Roy, A.K., Chatterjee, B. J. Biol. Chem. (2001) [Pubmed]
  20. Molecular cloning and expression of a full-length complementary DNA encoding the guinea pig adrenocortical estrogen sulfotransferase. Oeda, T., Lee, Y.C., Driscoll, W.J., Chen, H.C., Strott, C.A. Mol. Endocrinol. (1992) [Pubmed]
  21. Molecular markers of endocrine disruption in aquatic organisms. Rotchell, J.M., Ostrander, G.K. Journal of toxicology and environmental health. Part B, Critical reviews. (2003) [Pubmed]
  22. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Vergnes, L., Phan, J., Stolz, A., Reue, K. J. Lipid Res. (2003) [Pubmed]
  23. Pubertal augmentation in juvenile rhesus monkey testosterone production induced by invariant gonadotropin stimulation is inhibited by estrogen. Ramaswamy, S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  24. Immunohistochemical demonstration of isozyme- and strain-specific differences in the intralobular localizations and distributions of UDP-glucuronosyltransferases in livers of untreated rats. Knapp, S.A., Green, M.D., Tephly, T.R., Baron, J. Mol. Pharmacol. (1988) [Pubmed]
  25. The relationship between 17 beta hydroxysteroid dehydrogenase and breast tumour site and size. Beranek, P.A., Folkerd, E.J., Newton, C.J., Reed, M.J., Ghilchik, M.W., James, V.H. Int. J. Cancer (1985) [Pubmed]
  26. Estrogen and hydroxysteroid sulfotransferases in guinea pig adrenal cortex: cellular and subcellular distributions. Whitnall, M.H., Driscoll, W.J., Lee, Y.C., Strott, C.A. Endocrinology (1993) [Pubmed]
  27. Age and sex differences in the distribution of lipids, tetrazolium reductases and hydroxysteroid dehydrogenases in the gonads and adrenals of the bank vole (Clethrionomys glareoulus): a histochemical study. Tähkä, K.M. Biol. Reprod. (1979) [Pubmed]
  28. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., Penning, T.M. J. Biol. Chem. (2004) [Pubmed]
  29. Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice. Ahtiainen, P., Rulli, S.B., Shariatmadari, R., Pelliniemi, L.J., Toppari, J., Poutanen, M., Huhtaniemi, I.T. Oncogene (2005) [Pubmed]
  30. Rat liver cytosolic hydroxysteroid sulfotransferase (sulfotransferase a) catalyzing the formation of reactive sulfate esters from carcinogenic polycyclic hydroxymethylarenes. Ogura, K., Sohtome, T., Sugiyama, A., Okuda, H., Hiratsuka, A., Watabe, T. Mol. Pharmacol. (1990) [Pubmed]
  31. Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Schwarz, D., Kisselev, P., Schunck, W.H., Chernogolov, A., Boidol, W., Cascorbi, I., Roots, I. Pharmacogenetics (2000) [Pubmed]
  32. Steroidogenesis in rat leydig cells: changes in activity of 5-ane and 5-ene 3beta-hydroxysteroid dehydrogenases during sexual maturation. Wiebe, J.P. Endocrinology (1976) [Pubmed]
  33. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. Burczynski, M.E., Sridhar, G.R., Palackal, N.T., Penning, T.M. J. Biol. Chem. (2001) [Pubmed]
  34. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Her, C., Wood, T.C., Eichler, E.E., Mohrenweiser, H.W., Ramagli, L.S., Siciliano, M.J., Weinshilboum, R.M. Genomics (1998) [Pubmed]
  35. cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. Ogura, K., Kajita, J., Narihata, H., Watabe, T., Ozawa, S., Nagata, K., Yamazoe, Y., Kato, R. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  36. Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases. Falany, C.N., Ström, P., Swedmark, S. British journal of clinical pharmacology. (2005) [Pubmed]
  37. Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): Insights into positional and stereochemical preferences. Jin, Y., Penning, T.M. Steroids (2006) [Pubmed]
  38. Comparative anatomy of the aldo-keto reductase superfamily. Jez, J.M., Bennett, M.J., Schlegel, B.P., Lewis, M., Penning, T.M. Biochem. J. (1997) [Pubmed]
  39. Human Hydroxysteroid (17-{beta}) Dehydrogenase 1 Expression Enhances Estrogen Sensitivity of MCF-7 Breast Cancer Cell Xenografts. Husen, B., Huhtinen, K., Saloniemi, T., Messinger, J., Thole, H.H., Poutanen, M. Endocrinology (2006) [Pubmed]
  40. Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study. Sharp, S., Anderson, J.M., Coughtrie, M.W. Eur. J. Cancer (1994) [Pubmed]
  41. Molecular cloning of the alcohol/hydroxysteroid form (mSTa1) of sulfotransferase from mouse liver. Kong, A.T., Tao, D., Ma, M., Yang, L. Pharm. Res. (1993) [Pubmed]
  42. Analysis of bile acids by micro high-performance liquid chromatography with postcolumn enzyme reaction and fluorometric detection. Ishii, D., Murata, S., Takeuchi, T. J. Chromatogr. (1983) [Pubmed]
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