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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of cerebrovascular challenges on plasma endothelin.

Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive-endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-1 levels.[1]


  1. Effects of cerebrovascular challenges on plasma endothelin. Jordan, W., Decker, M., Kamrowski, H., Brunner, E., Ehrenreich, H., Hajak, G. Neurosci. Res. (2002) [Pubmed]
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