The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

EDN1  -  endothelin 1

Homo sapiens

Synonyms: ARCND3, ET1, Endothelin-1, HDLCQ7, PPET1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of EDN1


Psychiatry related information on EDN1


High impact information on EDN1


Chemical compound and disease context of EDN1


Biological context of EDN1


Anatomical context of EDN1


Associations of EDN1 with chemical compounds


Physical interactions of EDN1

  • The effects of ET-1 are mediated by binding to endothelin type A (ETA) and endothelin type B (ETB) receptors [28].
  • AIMS: The endothelin system plays a role in the complex pathophysiology of idiopathic dilated cardiomyopathy [29].
  • BACKGROUND: Endothelin-1 (ET-1) interacts with specific G-protein-coupled receptors to initiate short-term (contraction) and long-term (mitogenesis) events in target cells [30].
  • We conclude that ET-1 binding to ETB receptors causes a potent growth inhibition of human myofibroblastic Ito cells, which suggests that this peptide could play a key role in the negative control of liver fibrogenesis [31].
  • Endothelin-converting enzyme (ECE)-1 is a membrane-bound metalloprotease responsible for production of vasoactive endothelin (ET)-1 from inactive big ET-1 [32].

Enzymatic interactions of EDN1


Co-localisations of EDN1

  • ECE-1 immunostaining was colocalized to big ET-1 and ET-1 immunostaining, and correlated with disease activity (P < 0.05) [37].

Regulatory relationships of EDN1


Other interactions of EDN1


Analytical, diagnostic and therapeutic context of EDN1

  • These data demonstrate that Et-1 may be a risk factor in ischemic/reperfusion injury by inducing increased levels of the neutrophil chemoattractant IL-8 [4].
  • Arterial and venous plasma samples were obtained simultaneously, and ET-1 and ET-3 concentrations were determined in extracted plasma by two separate radioimmunoassays [43].
  • METHODS: Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intra-arterial infusion of a selective blocker of ETA receptors (BQ-123) and, on a separate occasion, to ET-1 were measured in 12 hypercholesterolemic patients and 12 normal control subjects [44].
  • Northern blot analysis demonstrated the expression of messenger RNA for prepro-ET-1 in the decidual tissue, but no such messenger RNA was observed in the villous tissue [45].
  • Reverse-phase high-pressure liquid chromatography of the conditioned media from the decidual cells revealed a major peak of ET-1-LI coeluting with standard ET-1 [45].


  1. beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. Kim, T.H., Xiong, H., Zhang, Z., Ren, B. Oncogene (2005) [Pubmed]
  2. Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes. Arjomand-Nahad, F., Landt, O., Stangl, K., Diefenbach, K., Roots, I. Clin. Chem. Lab. Med. (2006) [Pubmed]
  3. Dinucleotide repeat polymorphisms in EDN1 and NOS3 are not associated with severe diabetic retinopathy in type 1 or type 2 diabetes. Warpeha, K.M., Ah-Fat, F., Harding, S., Patterson, C.C., Xu, W., Hart, P.M., Chakravarthy, U., Hughes, A.E. Eye (London, England) (1999) [Pubmed]
  4. Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells. Hofman, F.M., Chen, P., Jeyaseelan, R., Incardona, F., Fisher, M., Zidovetzki, R. Blood (1998) [Pubmed]
  5. Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Shi-Wen, X., Rodríguez-Pascual, F., Lamas, S., Holmes, A., Howat, S., Pearson, J.D., Dashwood, M.R., du Bois, R.M., Denton, C.P., Black, C.M., Abraham, D.J., Leask, A. Mol. Cell. Biol. (2006) [Pubmed]
  6. HIV-1-induced production of endothelin-1 in an in vitro model of the human blood-brain barrier. Didier, N., Banks, W.A., Créminon, C., Dereuddre-Bosquet, N., Mabondzo, A. Neuroreport (2002) [Pubmed]
  7. Circulating endothelin parallels arterial blood pressure during sleep in healthy subjects. Charloux, A., Piquard, F., Geny, B., Ehrhart, J., Brandenberger, G. Regul. Pept. (2004) [Pubmed]
  8. Endothelin: emerging role in diabetic vascular complications. Hopfner, R.L., Gopalakrishnan, V. Diabetologia (1999) [Pubmed]
  9. Endothelin-1 in cerebrospinal fluid in elderly patients with hypertension and dementia. Nakajima, M., Morimoto, S., Takamoto, S., Kitano, S., Fukuo, K., Onishi, T., Ogihara, T. Hypertension (1994) [Pubmed]
  10. Effects of alcohol intake on endothelial function in men: a randomized controlled trial. Zilkens, R.R., Rich, L., Burke, V., Beilin, L.J., Watts, G.F., Puddey, I.B. J. Hypertens. (2003) [Pubmed]
  11. Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Brutsaert, D.L. Physiol. Rev. (2003) [Pubmed]
  12. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Roman, R.J. Physiol. Rev. (2002) [Pubmed]
  13. Regulation of the cerebral circulation: role of endothelium and potassium channels. Faraci, F.M., Heistad, D.D. Physiol. Rev. (1998) [Pubmed]
  14. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. Krum, H., Viskoper, R.J., Lacourciere, Y., Budde, M., Charlon, V. N. Engl. J. Med. (1998) [Pubmed]
  15. Endothelin-1 and its receptors A and B in human aldosterone-producing adenomas. Rossi, G., Belloni, A.S., Albertin, G., Zanin, L., Biasolo, M.A., Nussdorfer, G.G., Palù, G., Pessina, A.C. Hypertension (1995) [Pubmed]
  16. Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect. Lee, C.C., Chen, P.R., Lin, S., Tsai, S.C., Wang, B.W., Chen, W.W., Tsai, C.E., Shyu, K.G. J. Hypertens. (2004) [Pubmed]
  17. Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells. Stanimirovic, D.B., Yamamoto, T., Uematsu, S., Spatz, M. J. Neurochem. (1994) [Pubmed]
  18. Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts. Patel, K.V., Schrey, M.P. Br. J. Cancer (1995) [Pubmed]
  19. The endothelin system in human glioblastoma. Egidy, G., Eberl, L.P., Valdenaire, O., Irmler, M., Majdi, R., Diserens, A.C., Fontana, A., Janzer, R.C., Pinet, F., Juillerat-Jeanneret, L. Lab. Invest. (2000) [Pubmed]
  20. Association between glaucoma and gene polymorphism of endothelin type A receptor. Ishikawa, K., Funayama, T., Ohtake, Y., Kimura, I., Ideta, H., Nakamoto, K., Yasuda, N., Fukuchi, T., Fujimaki, T., Murakami, A., Asaoka, R., Hotta, Y., Kanamoto, T., Tanihara, H., Miyaki, K., Mashima, Y. Mol. Vis. (2005) [Pubmed]
  21. Linkage analysis of candidate endothelin pathway genes in nonsyndromic familial orofacial cleft. Pezzetti, F., Scapoli, L., Martinelli, M., Carinci, F., Brunelli, G., Carls, F.P., Palomba, F., Gombos, F., Carinci, P., Tognon, M. Ann. Hum. Genet. (2000) [Pubmed]
  22. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Immervoll, T., Loesgen, S., Dütsch, G., Gohlke, H., Herbon, N., Klugbauer, S., Dempfle, A., Bickeböller, H., Becker-Follmann, J., Rüschendorf, F., Saar, K., Reis, A., Wichmann, H.E., Wjst, M. Hum. Mutat. (2001) [Pubmed]
  23. Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex. Rossi, G., Albertin, G., Belloni, A., Zanin, L., Biasolo, M.A., Prayer-Galetti, T., Bader, M., Nussdorfer, G.G., Palù, G., Pessina, A.C. J. Clin. Invest. (1994) [Pubmed]
  24. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Haynes, W.G., Webb, D.J. Lancet (1994) [Pubmed]
  25. Molecular biology and biochemistry of the endothelins. Yanagisawa, M., Masaki, T. Trends Pharmacol. Sci. (1989) [Pubmed]
  26. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Seo, B., Oemar, B.S., Siebenmann, R., von Segesser, L., Lüscher, T.F. Circulation (1994) [Pubmed]
  27. Endothelin activation of an inwardly rectifying K+ current in atrial cells. Kim, D. Circ. Res. (1991) [Pubmed]
  28. Expression of endothelin-converting enzyme, endothelin-1 and endothelin receptors at the site of percutaneous coronary intervention in humans. Shirai, N., Naruko, T., Ohsawa, M., Ikura, Y., Sugama, Y., Hirayama, M., Kitabayashi, C., Ehara, S., Inoue, T., Itoh, A., Haze, K., Tanzawa, K., Yoshiyama, M., Yoshikawa, J., Ueda, M. J. Hypertens. (2006) [Pubmed]
  29. A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. Herrmann, S., Schmidt-Petersen, K., Pfeifer, J., Perrot, A., Bit-Avragim, N., Eichhorn, C., Dietz, R., Kreutz, R., Paul, M., Osterziel, K.J. Eur. Heart J. (2001) [Pubmed]
  30. Endothelin-1 production and agonist activities in cultured prostate-derived cells: implications for regulation of endothelin bioactivity and bioavailability in prostatic hyperplasia. Walden, P.D., Ittmann, M., Monaco, M.E., Lepor, H. Prostate (1998) [Pubmed]
  31. Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway. Mallat, A., Fouassier, L., Préaux, A.M., Gal, C.S., Raufaste, D., Rosenbaum, J., Dhumeaux, D., Jouneaux, C., Mavier, P., Lotersztajn, S. J. Clin. Invest. (1995) [Pubmed]
  32. Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells. Hunter, A.R., Turner, A.J. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  33. Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts. Chen, C.H., Cheng, T.H., Lin, H., Shih, N.L., Chen, Y.L., Chen, Y.S., Cheng, C.F., Lian, W.S., Meng, T.C., Chiu, W.T., Chen, J.J. Mol. Pharmacol. (2006) [Pubmed]
  34. Endothelin-1 induces tyrosine phosphorylation in human blood monocytes. Chisholm, L.J., Agrawal, D.K., Pearson, T.J., Edwards, J.D. Mol. Cell. Biochem. (1996) [Pubmed]
  35. Generation of human endothelin by cathepsin E. Lees, W.E., Kalinka, S., Meech, J., Capper, S.J., Cook, N.D., Kay, J. FEBS Lett. (1990) [Pubmed]
  36. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T., Holtz, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  37. Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines. Saleh, D., Furukawa, K., Tsao, M.S., Maghazachi, A., Corrin, B., Yanagisawa, M., Barnes, P.J., Giaid, A. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  38. Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. Spinella, F., Rosanò, L., Di Castro, V., Natali, P.G., Bagnato, A. J. Biol. Chem. (2004) [Pubmed]
  39. Chemokine- and cytokine-induced expression of endothelin 1 and endothelin-converting enzyme 1 in endothelial cells. Molet, S., Furukawa, K., Maghazechi, A., Hamid, Q., Giaid, A. J. Allergy Clin. Immunol. (2000) [Pubmed]
  40. Endothelin-1 upregulates MCAM in melanocytes. Mangahas, C.R., dela Cruz, G.V., Schneider, R.J., Jamal, S. J. Invest. Dermatol. (2004) [Pubmed]
  41. Endothelin ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Haynes, W.G., Strachan, F.E., Webb, D.J. Circulation (1995) [Pubmed]
  42. Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops. Guruli, G., Pflug, B.R., Pecher, S., Makarenkova, V., Shurin, M.R., Nelson, J.B. Blood (2004) [Pubmed]
  43. Endothelin-1 and -3 plasma concentrations in patients with cirrhosis: role of splanchnic and renal passage and liver function. Gerbes, A.L., Møller, S., Gülberg, V., Henriksen, J.H. Hepatology (1995) [Pubmed]
  44. Increased activity of endogenous endothelin in patients with hypercholesterolemia. Cardillo, C., Kilcoyne, C.M., Cannon, R.O., Panza, J.A. J. Am. Coll. Cardiol. (2000) [Pubmed]
  45. Synthesis and release of endothelin-1 by human decidual cells. Kubota, T., Kamada, S., Hirata, Y., Eguchi, S., Imai, T., Marumo, F., Aso, T. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
WikiGenes - Universities