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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Sanchez-Cespedes, M. et al.

Sanchez-Cespedes, Parrella, Esteller, Nomoto, Trink, Engles, Westra, Herman, Sidransky,

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

Frequent losses of chromosome 19p have recently been observed in sporadic lung adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped in the minimal-deleted region. Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors. We detected a high frequency of somatic alterations (mainly nonsense mutations) in primary lung adenocarcinomas and in lung cancer cell lines. Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.[1]

References

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Sanchez-Cespedes, M., Parrella, P., Esteller, M., Nomoto, S., Trink, B., Engles, J.M., Westra, W.H., Herman, J.G., Sidransky, D. Cancer Res. (2002) [Pubmed]

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