The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Peutz-Jeghers Syndrome

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Peutz-Jeghers Syndrome


High impact information on Peutz-Jeghers Syndrome


Chemical compound and disease context of Peutz-Jeghers Syndrome


Biological context of Peutz-Jeghers Syndrome


Anatomical context of Peutz-Jeghers Syndrome


Gene context of Peutz-Jeghers Syndrome


Analytical, diagnostic and therapeutic context of Peutz-Jeghers Syndrome


  1. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Corradetti, M.N., Inoki, K., Bardeesy, N., DePinho, R.A., Guan, K.L. Genes Dev. (2004) [Pubmed]
  2. Genetic predisposition and somatic diversification in tumor development and progression. Shibata, D., Aaltonen, L.A. Adv. Cancer Res. (2001) [Pubmed]
  3. Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Miyaki, M., Iijima, T., Hosono, K., Ishii, R., Yasuno, M., Mori, T., Toi, M., Hishima, T., Shitara, N., Tamura, K., Utsunomiya, J., Kobayashi, N., Kuroki, T., Iwama, T. Cancer Res. (2000) [Pubmed]
  4. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Bignell, G.R., Barfoot, R., Seal, S., Collins, N., Warren, W., Stratton, M.R. Cancer Res. (1998) [Pubmed]
  5. STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer. Resta, N., Simone, C., Mareni, C., Montera, M., Gentile, M., Susca, F., Gristina, R., Pozzi, S., Bertario, L., Bufo, P., Carlomagno, N., Ingrosso, M., Rossini, F.P., Tenconi, R., Guanti, G. Cancer Res. (1998) [Pubmed]
  6. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Jenne, D.E., Reimann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Müller, O., Back, W., Zimmer, M. Nat. Genet. (1998) [Pubmed]
  7. Images in Clinical Medicine: Peutz-Jeghers syndrome. Morrison, P.J., Nevin, N.C. N. Engl. J. Med. (1993) [Pubmed]
  8. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Martin, S.G., St Johnston, D. Nature (2003) [Pubmed]
  9. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Höglund, P., Järvinen, H., Kristo, P., Pelin, K., Ridanpää, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S., Olsen, A.S., Stratton, M.R., de la Chapelle, A., Aaltonen, L.A. Nature (1998) [Pubmed]
  10. Aromatase expression in human germinomas with possible biological effects. O'Marcaigh, A.S., Ledger, G.A., Roche, P.C., Parisi, J.E., Zimmerman, D. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  11. Peutz-Jeghers syndrome: molecular analysis of a three-generation kindred with a novel defect in the serine threonine kinase gene STK11. Trojan, J., Brieger, A., Raedle, J., Roth, W.K., Zeuzem, S. Am. J. Gastroenterol. (1999) [Pubmed]
  12. Treatment of mucocutaneous pigmentation in Peutz-Jeghers syndrome with potassium titanyl phosphate (KTP) laser. Zaheri, S., Chong, S.K., Harland, C.C. Clin. Exp. Dermatol. (2005) [Pubmed]
  13. Peutz Jeghers syndrome (gastro-intestinal polyposis) and its complications. Oonwala, Z.G., Aziz, S. JPMA. The Journal of the Pakistan Medical Association. (1985) [Pubmed]
  14. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Forcet, C., Etienne-Manneville, S., Gaude, H., Fournier, L., Debilly, S., Salmi, M., Baas, A., Olschwang, S., Clevers, H., Billaud, M. Hum. Mol. Genet. (2005) [Pubmed]
  15. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Guldberg, P., thor Straten, P., Ahrenkiel, V., Seremet, T., Kirkin, A.F., Zeuthen, J. Oncogene (1999) [Pubmed]
  16. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. Wang, Z.J., Ellis, I., Zauber, P., Iwama, T., Marchese, C., Talbot, I., Xue, W.H., Yan, Z.Y., Tomlinson, I. J. Pathol. (1999) [Pubmed]
  17. The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors. Kato, N., Romero, M., Catasus, L., Prat, J. Hum. Pathol. (2004) [Pubmed]
  18. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Lim, W., Hearle, N., Shah, B., Murday, V., Hodgson, S.V., Lucassen, A., Eccles, D., Talbot, I., Neale, K., Lim, A.G., O'Donohue, J., Donaldson, A., Macdonald, R.C., Young, I.D., Robinson, M.H., Lee, P.W., Stoodley, B.J., Tomlinson, I., Alderson, D., Holbrook, A.G., Vyas, S., Swarbrick, E.T., Lewis, A.A., Phillips, R.K., Houlston, R.S. Br. J. Cancer (2003) [Pubmed]
  19. Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. Jimenez, A.I., Fernandez, P., Dominguez, O., Dopazo, A., Sanchez-Cespedes, M. Cancer Res. (2003) [Pubmed]
  20. Peutz-Jeghers syndrome: case presentation. Costa, J. Obstetrics and gynecology. (1977) [Pubmed]
  21. Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes. Back, W., Loff, S., Jenne, D., Bleyl, U. J. Clin. Pathol. (1999) [Pubmed]
  22. Relative frequency and morphology of cancers in STK11 mutation carriers. Lim, W., Olschwang, S., Keller, J.J., Westerman, A.M., Menko, F.H., Boardman, L.A., Scott, R.J., Trimbath, J., Giardiello, F.M., Gruber, S.B., Gille, J.J., Offerhaus, G.J., de Rooij, F.W., Wilson, J.H., Spigelman, A.D., Phillips, R.K., Houlston, R.S. Gastroenterology (2004) [Pubmed]
  23. Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. McGarrity, T.J., Peiffer, L.P., Amos, C.I., Frazier, M.L., Ward, M.G., Howett, M.K. Am. J. Gastroenterol. (2003) [Pubmed]
  24. The tuberous sclerosis complex genes in tumor development. Mak, B.C., Yeung, R.S. Cancer Invest. (2004) [Pubmed]
  25. Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome. Marneros, A.G., Mehenni, H., Reichenberger, E., Antonarakis, S.E., Krieg, T., Olsen, B.R. Cytogenet. Cell Genet. (2001) [Pubmed]
  26. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. Sweet, K., Willis, J., Zhou, X.P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S.K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T.W., Frebourg, T., Teh, B.T., Marchuk, D.A., Aaltonen, L.A., Eng, C. JAMA (2005) [Pubmed]
  27. Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4). Abed, A.A., Günther, K., Kraus, C., Hohenberger, W., Ballhausen, W.G. Hum. Mutat. (2001) [Pubmed]
WikiGenes - Universities