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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Primary hepatic carcinoid tumor with metachronous lymph node metastasis after long-term follow up.

A case of hepatic carcinoid tumor occurring in a 71-year-old man is reported. The tumor was diagnosed initially as a hepatocellular carcinoma, and was then shown after resection histologically to be a carcinoid tumor. The tumor cells formed small nests and trabeculae separated by fibrous septa and were positive for Grimelius staining. Immunohistochemically, most of the tumor cells stained positive with chromogranin A and neuron-specific enolase. After a follow up for 5 years and 7 months, the patient developed tumors in lymph nodes between the remnant liver and the lesser curvature of the stomach with no tumors in other organs. Histologically, the tumor cells in the lymph nodes demonstrated a pattern of the immunostainings consistent with carcinoid tumor. After lymphadenectomy, the patient is free from recurrence in the regional lymph nodes for more than 1 year. This case is con-sidered to be a primary hepatic carcinoid tumor with metachronous lymph node metastasis.[1]


  1. Primary hepatic carcinoid tumor with metachronous lymph node metastasis after long-term follow up. Iimuro, Y., Deguchi, Y., Ueda, Y., Tanaka, A., Iwasa, Y., Ishihara, M., Mizuta, K., Yamamoto, Y., Ikai, I., Shimahara, Y., Yamaoka, Y. J. Gastroenterol. Hepatol. (2002) [Pubmed]
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