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MeSH Review

Lymph Node Excision

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Disease relevance of Lymph Node Excision


High impact information on Lymph Node Excision

  • This study compared the incidence of ITM after wide local excision (WLE), WLE plus SLND (SLND), or WLE plus elective lymphadenectomy (ELND) for primary melanoma [1].
  • PATIENTS AND METHODS: Immunohistochemical staining for p53, p21, pRB, and p16 was carried out on serial sections from archival specimens of 80 patients who underwent bilateral pelvic lymphadenectomy and radical cystectomy for bladder cancer (median follow-up, 101 months) [6].
  • PATIENTS AND METHODS: A total of 283 eligible patients with pT3-4a and/or node-positive disease were randomly assigned after radical nephrectomy and lymphadenectomy to observation or to interferon alfa-NL (Wellferon, Burroughs-Wellcome, Research Park, NC) given daily for 5 days every 3 weeks for up to 12 cycles [7].
  • CONCLUSION: The addition of concurrent cisplatin-based CT to RT significantly improves progression-free and overall survival for high-risk, early-stage patients who undergo radical hysterectomy and pelvic lymphadenectomy for carcinoma of the cervix [8].
  • CONCLUSION: The prognosis after resection and adequate lymphadenectomy does not differ between patients with GSC and PGC [9].

Chemical compound and disease context of Lymph Node Excision


Biological context of Lymph Node Excision


Anatomical context of Lymph Node Excision

  • Superiority of en bloc pelvic lymphadenectomy versus conventional resection was observed in all cases of Dukes' Stage C, Astler-Coller Stage C1, Level II (adjacent) lymph nodes, and Level I (proximal) lymph nodes and was most effective in combination with sphincter-preserving operations [20].
  • When selecting antibiotics for prophylactic use against infections in the retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy, on the basis of drug transfer, flomoxef, cefminox, cefbuperazone, ceftazidime, and cefpimizole were considered to be the drugs of first choice at a dose of 1 g [21].
  • Treatment consisted of unilateral pelvic and inguinal lymphadenectomy, and a combined course of external beam and interstitial radiation therapy to the distal urethra and penis by the Henschke modification of the Paris technique [22].
  • We report our experience with 11 cases of yolk sac tumors, which were treated between 1960 and 1982 at the Hôpital Sainte-Justine and the Montreal Children's Hospital. The role of lymphadenectomy in yolk sac tumors is analyzed critically and put into perspective with the use of serum alpha-fetoprotein [23].
  • Extirpation of the bladder and anterior proximal prostate en bloc with preservation of the vasa deferentia, seminal vesicles, posterior prostate, and neurovascular bundles was performed after pelvic lymphadenectomy [24].

Associations of Lymph Node Excision with chemical compounds


Gene context of Lymph Node Excision


Analytical, diagnostic and therapeutic context of Lymph Node Excision


  1. Sentinel lymphadenectomy does not increase the incidence of in-transit metastases in primary melanoma. Kang, J.C., Wanek, L.A., Essner, R., Faries, M.B., Foshag, L.J., Morton, D.L. J. Clin. Oncol. (2005) [Pubmed]
  2. Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer. Cragun, J.M., Havrilesky, L.J., Calingaert, B., Synan, I., Secord, A.A., Soper, J.T., Clarke-Pearson, D.L., Berchuck, A. J. Clin. Oncol. (2005) [Pubmed]
  3. Surgical/pathologic-stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. Bunt, A.M., Hermans, J., Smit, V.T., van de Velde, C.J., Fleuren, G.J., Bruijn, J.A. J. Clin. Oncol. (1995) [Pubmed]
  4. Complication of 125 iodine implantation and pelvic lymphadenectomy for prostatic cancer with special reference to patients who had failed external beam therapy as their initial mode of therapy. Cumes, D.M., Goffinet, D.R., Martinez, A., Stamey, T.A. J. Urol. (1981) [Pubmed]
  5. Histochemical examination of expression of ras p21 protein and R 1881-binding protein in human prostatic cancers. Sumiya, H., Masai, M., Akimoto, S., Yatani, R., Shimazaki, J. Eur. J. Cancer (1990) [Pubmed]
  6. p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. Shariat, S.F., Tokunaga, H., Zhou, J., Kim, J., Ayala, G.E., Benedict, W.F., Lerner, S.P. J. Clin. Oncol. (2004) [Pubmed]
  7. Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: an Eastern Cooperative Oncology Group/Intergroup trial. Messing, E.M., Manola, J., Wilding, G., Propert, K., Fleischmann, J., Crawford, E.D., Pontes, J.E., Hahn, R., Trump, D. J. Clin. Oncol. (2003) [Pubmed]
  8. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. Peters, W.A., Liu, P.Y., Barrett, R.J., Stock, R.J., Monk, B.J., Berek, J.S., Souhami, L., Grigsby, P., Gordon, W., Alberts, D.S. J. Clin. Oncol. (2000) [Pubmed]
  9. Prognostic factors in gastric stump carcinoma. Thorban, S., Böttcher, K., Etter, M., Roder, J.D., Busch, R., Siewert, J.R. Ann. Surg. (2000) [Pubmed]
  10. Effect of mini-dose heparin on lymphocele formation following extraperitoneal pelvic lymphadenectomy. Catalona, W.J., Kadmon, D., Crane, D.B. J. Urol. (1980) [Pubmed]
  11. Mucinous adenocarcinoma of the prostate and hormone sensitivity. Teichman, J.M., Shabaik, A., Demby, A.M. J. Urol. (1994) [Pubmed]
  12. Morbidity of modified prophylactic inguinal lymphadenectomy for squamous cell carcinoma of the penis. Coblentz, T.R., Theodorescu, D. J. Urol. (2002) [Pubmed]
  13. The risk of dying of prostate cancer in patients with clinically localized disease. Lerner, S.P., Seale-Hawkins, C., Carlton, C.E., Scardino, P.T. J. Urol. (1991) [Pubmed]
  14. Preoperative diagnosis and treatment results in 106 patients with uterine sarcoma in Hokkaido, Japan. Sagae, S., Yamashita, K., Ishioka, S., Nishioka, Y., Terasawa, K., Mori, M., Yamashiro, K., Kanemoto, T., Kudo, R. Oncology (2004) [Pubmed]
  15. Local delayed cutaneous hypersensitivity reactions in breast cancer patients with and without removal of axillary lymph nodes. Schick, P.M., Shabot, M.M., Block, J.B., Rosenbloom, B.E., Burleigh, J., Pilch, Y.H. Am. J. Surg. (1976) [Pubmed]
  16. Pharmacokinetics of miconazole in serum and exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy. Mikamo, H., Kawazoe, K., Sato, Y., Ito, K., Tamaya, T. Int. J. Antimicrob. Agents (1997) [Pubmed]
  17. Staging of primary cervical cancers: the role of nuclear medicine. Belhocine, T., Kridelka, F., Thille, A., De Barsy, C., Foidart-Willems, J., Hustinx, R., Rigo, P. Crit. Rev. Oncol. Hematol. (2003) [Pubmed]
  18. Prediction of prostate carcinoma stage by quantitative biopsy pathology. Veltri, R.W., Miller, M.C., Partin, A.W., Poole, E.C., O'Dowd, G.J. Cancer (2001) [Pubmed]
  19. The effect of platinum-based combination chemotherapy on the lymph nodes in advanced-stage epithelial ovarian cancer: does it decrease the incidence of lymph node involvement? Simsek, T., Simsek, M., Pesterelli, E., Karaveli, S., Trak, B. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. (2002) [Pubmed]
  20. En bloc pelvic lymphadenectomy and sphincter preservation in the surgical management of rectal cancer. Enker, W.E., Pilipshen, S.J., Heilweil, M.L., Stearns, M.W., Janov, A.J., Hertz, R.E., Sternberg, S.S. Ann. Surg. (1986) [Pubmed]
  21. Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy. Ito, K., Hayasaki, M., Tamaya, T. Antimicrob. Agents Chemother. (1990) [Pubmed]
  22. Primary carcinoma of the distal male urethra: a case treated with lymphadenectomy and interstitial radiation therapy. Ticho, B.H., Perez-Tamayo, C., Konnak, J.W. J. Urol. (1988) [Pubmed]
  23. Yolk sac tumor of the testicle: is retroperitoneal lymph node dissection necessary? Homsy, Y., Arrojo-Vila, F., Khoriaty, N., Demers, J. J. Urol. (1984) [Pubmed]
  24. Erection- and ejaculation-preserving cystectomy with orthotopic urinary diversion: is it feasible? Girgin, C., Oder, M., Sahin, M.O., Sezer, A., Berkmen, S., Aydin, R., Dincel, C. J. Androl. (2006) [Pubmed]
  25. Sentinel node biopsy for cutaneous melanoma in the head and neck. Medina-Franco, H., Beenken, S.W., Heslin, M.J., Urist, M.M. Ann. Surg. Oncol. (2001) [Pubmed]
  26. Iodine-125 implants for carcinoma of the prostate. Peschel, R.E., Fogel, T.D., Kacinski, B.M., Kelly, K., Mate, T.P. Int. J. Radiat. Oncol. Biol. Phys. (1985) [Pubmed]
  27. The significance of DNA-ploidy and S-phase fraction in node-positive (stage D1) prostate cancer treated with androgen ablation. Pollack, A., Troncoso, P., Zagars, G.K., von Eschenbach, A.C., Mak, A.C., Wu, C.S., Terry, N.H. Prostate (1997) [Pubmed]
  28. Return of fertility after treatment for nonseminomatous testicular cancer: changing concepts. Lange, P.H., Narayan, P., Vogelzang, N.J., Shafer, R.B., Kennedy, B.J., Fraley, E.E. J. Urol. (1983) [Pubmed]
  29. The use of fluorescein in radical inguinal lymphadenectomy. Smith, J.A., Middleton, R.G. J. Urol. (1979) [Pubmed]
  30. Expression of vascular endothelial growth factor C and D (VEGF-C and -D) is an important risk factor for lymphatic metastasis in undifferentiated early gastric carcinoma. Ishikawa, M., Kitayama, J., Kazama, S., Nagawa, H. Jpn. J. Clin. Oncol. (2003) [Pubmed]
  31. Quantification of melanoma micrometastases in sentinel lymph nodes using real-time RT-PCR. Giese, T., Engstner, M., Mansmann, U., Hartschuh, W., Arden, B. J. Invest. Dermatol. (2005) [Pubmed]
  32. Immediate radical prostatectomy in patients with atypical small acinar proliferation. Over treatment? Brausi, M., Castagnetti, G., Dotti, A., De Luca, G., Olmi, R., Cesinaro, A.M. J. Urol. (2004) [Pubmed]
  33. Minimally invasive staging of patients with melanoma: sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction. Goydos, J.S., Ravikumar, T.S., Germino, F.J., Yudd, A., Bancila, E. J. Am. Coll. Surg. (1998) [Pubmed]
  34. The expression pattern of UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyl transferase-3 in early gastric carcinoma. Ishikawa, M., Kitayama, J., Nariko, H., Kohno, K., Nagawa, H. Journal of surgical oncology. (2004) [Pubmed]
  35. Effect of surgery and adjuvant chemotherapy on the R3327 MAT-Ly Lu tumor. Kadmon, D., Heston, W.D., Fair, W.R. Prostate (1981) [Pubmed]
  36. Extranodal extension in lymph node-positive prostate cancer. Cheng, L., Pisansky, T.M., Ramnani, D.M., Leibovich, B.C., Cheville, J.C., Slezak, J., Bergstralh, E.J., Zincke, H., Bostwick, D.G. Mod. Pathol. (2000) [Pubmed]
  37. Phase I-II trial of twice-weekly gemcitabine and concomitant irradiation in patients undergoing pancreaticoduodenectomy with extended lymphadenectomy for locally advanced pancreatic cancer. Joensuu, T.K., Kiviluoto, T., Kärkkäinen, P., Vento, P., Kivisaari, L., Tenhunen, M., Westberg, R., Elomaa, I. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  38. p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. Lopes, A., Bezerra, A.L., Pinto, C.A., Serrano, S.V., de MellO, C.A., Villa, L.L. J. Urol. (2002) [Pubmed]
  39. Effectiveness of extended lymphadenectomy in noncurative gastrectomy. Baba, H., Maehara, Y., Inutsuka, S., Takeuchi, H., Oshiro, T., Adachi, Y., Sugimachi, K. Am. J. Surg. (1995) [Pubmed]
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