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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The TC10- interacting protein CIP4/2 is required for insulin- stimulated Glut4 translocation in 3T3L1 adipocytes.

The GTPase TC10 plays a critical role in insulin-stimulated glucose transport. We report here the identification of the TC10- interacting protein CIP4/2 (Cdc42-interacting protein 4/2) as an effector in this pathway. CIP4/2 localizes to an intracellular compartment under basal conditions and translocates to the plasma membrane on insulin stimulation. Overexpression of constitutively active TC10 brings CIP4/2 to the plasma membrane, whereas overexpression of an inhibitory form of TC10 blocks the translocation of CIP4/2 produced by insulin. Overexpression of mutant forms of CIP4/2 containing an N-terminal deletion or with diminished TC10 binding inhibits insulin- stimulated Glut4 translocation. These data suggest that CIP4/2 may play an important role in insulin- stimulated glucose transport as a downstream effector of TC10.[1]


  1. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Chang, L., Adams, R.D., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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