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Gene Review

RHOQ  -  ras homolog family member Q

Homo sapiens

Synonyms: ARHQ, HEL-S-42, RASL7A, Ras-like protein TC10, Ras-like protein family member 7A, ...
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Disease relevance of RHOQ

  • Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10 [1].

High impact information on RHOQ


Biological context of RHOQ


Anatomical context of RHOQ

  • The effect of TC10 is independent of the level of CFTR expression, because a similar effect was observed in a stable cell line that expresses one-tenth of CFTR [1].
  • Despite its overall similarity to TC10 and Cdc42, the constitutively active TCL mutant displays distinct morphogenic activity in REF-52 fibroblasts, producing large and dynamic F-actin-rich ruffles on the dorsal cell membrane [8].
  • TC10 mRNA expression was very low in normal motor neurons; however, axotomy induced its expression dramatically [6].
  • Cultured dorsal root ganglia exhibited dramatic neurite extension secondary to adenovirus-mediated expression of TC10 [6].
  • These data demonstrate that TC10 and H-Ras can both traffic to the plasma membrane by at least two distinct transport mechanisms in adipocytes, one dependent upon intracellular membrane transport and another independent of the classical secretory membrane system [5].

Associations of RHOQ with chemical compounds

  • We show the inhibitory TC10 (T31N) mutant, which abrogates insulin-stimulated GLUT4 translocation and glucose transport, also inhibits both cortical localization of N-WASP and F-actin formation in response to insulin [9].
  • Furthermore, TC10 directly bound to Golgi COPI coat proteins through a dilysine motif in the carboxyl terminal domain consistent with a role for TC10 regulating actin polymerization on membrane transport vesicles [10].

Physical interactions of RHOQ


Regulatory relationships of RHOQ

  • These data suggest that CIP4/2 may play an important role in insulin-stimulated glucose transport as a downstream effector of TC10 [4].
  • In support of this model, a GTPase-deficient TC10 mutant potently inhibited EGF-induced vesicular fusion in HeLa cells and depolarization-induced neuronal secretion [13].
  • Furthermore, we found that GTP hydrolysis by TC10 in the vicinity of the plasma membrane was dependent on Rac and the redox-regulated Rho GAP, p190RhoGAP-A [13].

Other interactions of RHOQ

  • Metabolic pulse-chase experiments show that TC10 did not affect CFTR maturation, suggesting that it exerts its effects on the mature CFTR [1].
  • On the other hand, replacement of the corresponding region of TC10 with the AB region enabled TC10 to acquire ACK-binding ability [14].
  • Overexpression of mutant forms of CIP4/2 containing an N-terminal deletion or with diminished TC10 binding inhibits insulin-stimulated Glut4 translocation [4].
  • The Borg (binder of Rho GTPases) family proteins interact with CDC42 and TC10 in a guanosine triphosphate (GTP)-dependent manner [15].
  • In the present study, we raised the possibility that Rhotekin interacts with a PDZ-protein, PIST (PDZ domain protein interacting specifically with TC10) in vitro, and found that these proteins form complex in the rat brain tissues [16].


  1. Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. Cheng, J., Wang, H., Guggino, W.B. J. Biol. Chem. (2005) [Pubmed]
  2. TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. Chiang, S.H., Hwang, J., Legendre, M., Zhang, M., Kimura, A., Saltiel, A.R. EMBO J. (2003) [Pubmed]
  3. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. Michaelson, D., Silletti, J., Murphy, G., D'Eustachio, P., Rush, M., Philips, M.R. J. Cell Biol. (2001) [Pubmed]
  4. The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Chang, L., Adams, R.D., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Watson, R.T., Furukawa, M., Chiang, S.H., Boeglin, D., Kanzaki, M., Saltiel, A.R., Pessin, J.E. Mol. Cell. Biol. (2003) [Pubmed]
  6. The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. Tanabe, K., Tachibana, T., Yamashita, T., Che, Y.H., Yoneda, Y., Ochi, T., Tohyama, M., Yoshikawa, H., Kiyama, H. J. Neurosci. (2000) [Pubmed]
  7. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. Murphy, G.A., Solski, P.A., Jillian, S.A., Pérez de la Ossa, P., D'Eustachio, P., Der, C.J., Rush, M.G. Oncogene (1999) [Pubmed]
  8. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. Vignal, E., De Toledo, M., Comunale, F., Ladopoulou, A., Gauthier-Rouvière, C., Blangy, A., Fort, P. J. Biol. Chem. (2000) [Pubmed]
  9. A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. Jiang, Z.Y., Chawla, A., Bose, A., Way, M., Czech, M.P. J. Biol. Chem. (2002) [Pubmed]
  10. Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Kanzaki, M., Watson, R.T., Hou, J.C., Stamnes, M., Saltiel, A.R., Pessin, J.E. Mol. Biol. Cell (2002) [Pubmed]
  11. Compartmentalization of the exocyst complex in lipid rafts controls glut4 vesicle tethering. Inoue, M., Chiang, S.H., Chang, L., Chen, X.W., Saltiel, A.R. Mol. Biol. Cell (2006) [Pubmed]
  12. TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin. Coisy-Quivy, M., Touzet, O., Bourret, A., Hipskind, R.A., Mercier, J., Fort, P., Philips, A. J. Cell. Sci. (2009) [Pubmed]
  13. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Kawase, K., Nakamura, T., Takaya, A., Aoki, K., Namikawa, K., Kiyama, H., Inagaki, S., Takemoto, H., Saltiel, A.R., Matsuda, M. Dev. Cell (2006) [Pubmed]
  14. Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase. Gu, Y., Lin, Q., Childress, C., Yang, W. J. Biol. Chem. (2004) [Pubmed]
  15. Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue. Osada, N., Kusuda, J., Suzuki, Y., Sugano, S., Hashimoto, K. J. Hum. Genet. (2000) [Pubmed]
  16. Possible interaction of a Rho effector, Rhotekin, with a PDZ-protein, PIST, at synapses of hippocampal neurons. Ito, H., Iwamoto, I., Mizutani, K., Morishita, R., Deguchi, T., Nozawa, Y., Asano, T., Nagata, K. Neurosci. Res. (2006) [Pubmed]
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