The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons.

Synaptopodin is the first member of a novel class of proline-rich actin-associated proteins. In brain, it is present in the neck of a subset of mature telencephalic spines and is associated closely with the spine apparatus, a Ca(2+) storing organelle within the spine compartment. The characteristic region- and lamina-specific distribution of synaptopodin in rat brain suggested that the distribution pattern of synaptopodin depends on the cytoarchitectonic arrangement of spine-bearing neurons. To test this hypothesis, synaptopodin was studied in the cortex, striatum, and hippocampus of normal and reeler mice, in which developmental cell migration defects have disrupted the normal array of cells. In situ hybridization histochemistry as well as light- and electron microscopic immunocytochemistry were used. In brain of normal mice, the pattern of synaptopodin mRNA-expressing cells corresponds to that of spine-bearing neurons and synaptopodin protein is found in a region- and lamina-specific distribution pattern. It is specifically sorted to the spine neck where it is associated closely with the spine apparatus. In brain of reeler mice, the pattern of synaptopodin mRNA-expressing cells corresponds to that of the abnormally positioned spine-bearing neurons and the region- and lamina-specific distribution pattern is absent or altered. Nevertheless, synaptopodin was specifically sorted to the spine neck, as in controls. These data demonstrate that the light microscopic distribution pattern of synaptopodin protein depends on the position and orientation of the spine-bearing neurons. The intracellular sorting process, however, is independent of positional cues.[1]

References

  1. Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons. Deller, T., Haas, C.A., Deissenrieder, K., Del Turco, D., Coulin, C., Gebhardt, C., Drakew, A., Schwarz, K., Mundel, P., Frotscher, M. J. Comp. Neurol. (2002) [Pubmed]
 
WikiGenes - Universities