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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mice, Neurologic Mutants

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Disease relevance of Mice, Neurologic Mutants


Psychiatry related information on Mice, Neurologic Mutants


High impact information on Mice, Neurologic Mutants


Chemical compound and disease context of Mice, Neurologic Mutants


Biological context of Mice, Neurologic Mutants


Anatomical context of Mice, Neurologic Mutants


Associations of Mice, Neurologic Mutants with chemical compounds


Gene context of Mice, Neurologic Mutants

  • Seizure activity has been reported in a Girk2 null mutant mouse lacking GIRK2 channels but showing normal cerebellar development as well as in the weaver mouse, which has mutated GIRK2 channels and shows abnormal development [28].
  • The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a [29].
  • Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system [30].
  • To explore in vivo parallels of these findings, we investigated Bag1 expression in the developing mouse nervous system using immunohistochemical methods [31].
  • These findings suggest that leptin, a peripheral signal of energy stores in adult animals, is required for normal neuronal and glial maturation in the mouse nervous system [32].

Analytical, diagnostic and therapeutic context of Mice, Neurologic Mutants


  1. Dystonin is essential for maintaining neuronal cytoskeleton organization. Dalpé, G., Leclerc, N., Vallée, A., Messer, A., Mathieu, M., De Repentigny, Y., Kothary, R. Mol. Cell. Neurosci. (1998) [Pubmed]
  2. Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation. Babic, N., Mettenleiter, T.C., Ugolini, G., Flamand, A., Coulon, P. Virology (1994) [Pubmed]
  3. Plasminogen activators in the neuromuscular system of the wobbler mutant mouse. Blondet, B., Barlovatz-Meimon, G., Festoff, B.W., Soria, C., Soria, J., Rieger, F., Hantai, D. Brain Res. (1992) [Pubmed]
  4. Mutation analysis of the inwardly rectifying K(+) channels KCNJ6 (GIRK2) and KCNJ3 (GIRK1) in juvenile myoclonic epilepsy. Hallmann, K., Durner, M., Sander, T., Steinlein, O.K. Am. J. Med. Genet. (2000) [Pubmed]
  5. Estrogen receptors in the wobbler mouse. Siegel, L.I., Fox, T.O. Life Sci. (1985) [Pubmed]
  6. Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Fatemi, S.H. Mol. Psychiatry (2001) [Pubmed]
  7. Olfactory discrimination learning deficit in heterozygous reeler mice. Larson, J., Hoffman, J.S., Guidotti, A., Costa, E. Brain Res. (2003) [Pubmed]
  8. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Hong, S.E., Shugart, Y.Y., Huang, D.T., Shahwan, S.A., Grant, P.E., Hourihane, J.O., Martin, N.D., Walsh, C.A. Nat. Genet. (2000) [Pubmed]
  9. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Patil, N., Cox, D.R., Bhat, D., Faham, M., Myers, R.M., Peterson, A.S. Nat. Genet. (1995) [Pubmed]
  10. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS. Millonig, J.H., Millen, K.J., Hatten, M.E. Nature (2000) [Pubmed]
  11. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Sheldon, M., Rice, D.S., D'Arcangelo, G., Yoneshima, H., Nakajima, K., Mikoshiba, K., Howell, B.W., Cooper, J.A., Goldowitz, D., Curran, T. Nature (1997) [Pubmed]
  12. NK cytotoxic activity and relative distribution of NK cells in 3-acetylpyridine influenced mice. Mandáková, P., Cervinková, M., Virtová, M., Síma, P. Folia Microbiol. (Praha) (2001) [Pubmed]
  13. A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Yue, Z., Horton, A., Bravin, M., DeJager, P.L., Selimi, F., Heintz, N. Neuron (2002) [Pubmed]
  14. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. Macleod, K.F., Hu, Y., Jacks, T. EMBO J. (1996) [Pubmed]
  15. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Srinivasan, A., Roth, K.A., Sayers, R.O., Shindler, K.S., Wong, A.M., Fritz, L.C., Tomaselli, K.J. Cell Death Differ. (1998) [Pubmed]
  16. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Ruberte, E., Friederich, V., Chambon, P., Morriss-Kay, G. Development (1993) [Pubmed]
  17. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Lu, W., Tsirka, S.E. Development (2002) [Pubmed]
  18. Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum. Roffler-Tarlov, S., Graybiel, A.M. Nature (1984) [Pubmed]
  19. Regulation of Purkinje cell alignment by reelin as revealed with CR-50 antibody. Miyata, T., Nakajima, K., Mikoshiba, K., Ogawa, M. J. Neurosci. (1997) [Pubmed]
  20. Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons. Cariboni, A., Rakic, S., Liapi, A., Maggi, R., Goffinet, A., Parnavelas, J.G. Development (2005) [Pubmed]
  21. Evidence for a cell-specific action of Reelin in the spinal cord. Phelps, P.E., Rich, R., Dupuy-Davies, S., Ríos, Y., Wong, T. Dev. Biol. (2002) [Pubmed]
  22. Different actions of gabapentin and baclofen in hippocampus from weaver mice. Bertrand, S., Morin, F., Lacaille, J.C. Hippocampus. (2003) [Pubmed]
  23. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Zuo, J., De Jager, P.L., Takahashi, K.A., Jiang, W., Linden, D.J., Heintz, N. Nature (1997) [Pubmed]
  24. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Liss, B., Haeckel, O., Wildmann, J., Miki, T., Seino, S., Roeper, J. Nat. Neurosci. (2005) [Pubmed]
  25. Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide. Rougon, G., Deagostini-Bazin, H., Hirn, M., Goridis, C. EMBO J. (1982) [Pubmed]
  26. Reelin function in neural stem cell biology. Kim, H.M., Qu, T., Kriho, V., Lacor, P., Smalheiser, N., Pappas, G.D., Guidotti, A., Costa, E., Sugaya, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Tremolizzo, L., Carboni, G., Ruzicka, W.B., Mitchell, C.P., Sugaya, I., Tueting, P., Sharma, R., Grayson, D.R., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  28. Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Slesinger, P.A., Stoffel, M., Jan, Y.N., Jan, L.Y. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  29. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Jones, J.M., Huang, J.D., Mermall, V., Hamilton, B.A., Mooseker, M.S., Escayg, A., Copeland, N.G., Jenkins, N.A., Meisler, M.H. Hum. Mol. Genet. (2000) [Pubmed]
  30. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Tsai, L.H., Takahashi, T., Caviness, V.S., Harlow, E. Development (1993) [Pubmed]
  31. Bag1 is a regulator and marker of neuronal differentiation. Kermer, P., Krajewska, M., Zapata, J.M., Takayama, S., Mai, J., Krajewski, S., Reed, J.C. Cell Death Differ. (2002) [Pubmed]
  32. Regulation of neuronal and glial proteins by leptin: implications for brain development. Ahima, R.S., Bjorbaek, C., Osei, S., Flier, J.S. Endocrinology (1999) [Pubmed]
  33. In situ hybridization analysis of Girk2 expression in the developing central nervous system in normal and weaver mice. Wei, J., Dlouhy, S.R., Bayer, S., Piva, R., Verina, T., Wang, Y., Feng, Y., Dupree, B., Hodes, M.E., Ghetti, B. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  34. Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia. Ballmaier, M., Zoli, M., Leo, G., Agnati, L.F., Spano, P. Eur. J. Neurosci. (2002) [Pubmed]
  35. The dorsal cochlear nucleus of the adult lurcher mouse is specifically invaded by embryonic grafted Purkinje cells. Dumesnil-Bousez, N., Sotelo, C. Brain Res. (1993) [Pubmed]
  36. Rat neurological disease creeping is caused by a mutation in the reelin gene. Yokoi, N., Namae, M., Wang, H.Y., Kojima, K., Fuse, M., Yasuda, K., Serikawa, T., Seino, S., Komeda, K. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  37. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Taguchi, A., Wanaka, A., Mori, T., Matsumoto, K., Imai, Y., Tagaki, T., Tohyama, M. Brain Res. Mol. Brain Res. (1996) [Pubmed]
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