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Gene Review

Synpo  -  synaptopodin

Mus musculus

Synonyms: 9030217H17Rik, 9130229N11, 9330140I15Rik, AW046661, Kiaa1029, ...
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Disease relevance of Synpo


High impact information on Synpo


Biological context of Synpo


Anatomical context of Synpo


Associations of Synpo with chemical compounds


Other interactions of Synpo


Analytical, diagnostic and therapeutic context of Synpo


  1. Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. Asanuma, K., Kim, K., Oh, J., Giardino, L., Chabanis, S., Faul, C., Reiser, J., Mundel, P. J. Clin. Invest. (2005) [Pubmed]
  2. Angiotensin II Type 1 Receptor Blockade Inhibits the Development and Progression of HIV-Associated Nephropathy in a Mouse Model. Hiramatsu, N., Hiromura, K., Shigehara, T., Kuroiwa, T., Ideura, H., Sakurai, N., Takeuchi, S., Tomioka, M., Ikeuchi, H., Kaneko, Y., Ueki, K., Kopp, J.B., Nojima, Y. J. Am. Soc. Nephrol. (2007) [Pubmed]
  3. Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis. Moeller, M.J., Soofi, A., Hartmann, I., Le Hir, M., Wiggins, R., Kriz, W., Holzman, L.B. J. Am. Soc. Nephrol. (2004) [Pubmed]
  4. Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes. Nelson, P.J., Gelman, I.H., Klotman, P.E. J. Am. Soc. Nephrol. (2001) [Pubmed]
  5. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Garovic, V.D., Wagner, S.J., Petrovic, L.M., Gray, C.E., Hall, P., Sugimoto, H., Kalluri, R., Grande, J.P. Nephrol. Dial. Transplant. (2007) [Pubmed]
  6. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Yanagida-Asanuma, E., Asanuma, K., Kim, K., Donnelly, M., Young Choi, H., Hyung Chang, J., Suetsugu, S., Tomino, Y., Takenawa, T., Faul, C., Mundel, P. Am. J. Pathol. (2007) [Pubmed]
  7. Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons. Deller, T., Haas, C.A., Deissenrieder, K., Del Turco, D., Coulin, C., Gebhardt, C., Drakew, A., Schwarz, K., Mundel, P., Frotscher, M. J. Comp. Neurol. (2002) [Pubmed]
  8. Retinoic Acid Inhibits HIV-1-Induced Podocyte Proliferation through the cAMP Pathway. He, J.C., Lu, T.C., Fleet, M., Sunamoto, M., Husain, M., Fang, W., Neves, S., Chen, Y., Shankland, S., Iyengar, R., Klotman, P.E. J. Am. Soc. Nephrol. (2007) [Pubmed]
  9. Synaptopodin and 4 novel genes identified in primary sensory neurons. Verpoorten, N., Verhoeven, K., Weckx, S., Jacobs, A., Serneels, S., Del Favero, J., Ceuterick, C., Van Bockstaele, D.R., Berneman, Z.N., Van den Bosch, L., Robberecht, W., Nobbio, L., Schenone, A., Dessaud, E., deLapeyrière, O., Huylebroeck, D., Zwijsen, A., De Jonghe, P., Timmerman, V. Mol. Cell. Neurosci. (2005) [Pubmed]
  10. Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. Bas Orth, C., Vlachos, A., Del Turco, D., Burbach, G.J., Haas, C.A., Mundel, P., Feng, G., Frotscher, M., Deller, T. J. Comp. Neurol. (2005) [Pubmed]
  11. Glomerular localization of erythropoietin receptor mRNA and protein in neonatal and mature mouse kidney. Echigoya, M.H., Obikane, K., Nakashima, T., Sasaki, S. Nephron Exp. Nephrol. (2005) [Pubmed]
  12. Podocytes respond to mechanical stress in vitro. Endlich, N., Kress, K.R., Reiser, J., Uttenweiler, D., Kriz, W., Mundel, P., Endlich, K. J. Am. Soc. Nephrol. (2001) [Pubmed]
  13. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. Husain, M., D'Agati, V.D., He, J.C., Klotman, M.E., Klotman, P.E. AIDS (2005) [Pubmed]
  14. Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines. Schiwek, D., Endlich, N., Holzman, L., Holthöfer, H., Kriz, W., Endlich, K. Kidney Int. (2004) [Pubmed]
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