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Manetta, J. et al.

Manetta, Brun, Maimoun, Callis, Préfaut, Mercier,

Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis.

The aim of this study was to compare circulating levels of growth hormone ( GH), IGF-I, and IGF-binding protein (IGFBP)-1 and IGFBP-3 in response to a long-duration endurance exercise in trained vs. sedentary middle-aged males and to determine whether a relationship with glucose homeostasis exists. Seven trained men (Tr) were compared with seven age-matched sedentary men (Sed) during two trials of 60 min of cycling exercise performed below (-VT) and above (+VT) the ventilatory threshold. Insulin sensitivity (S(I)) was higher in Tr than in Sed (P < 0.001). Basal GH, IGF-I, and IGFBP-1 and -3 were higher in Tr (P < 0.05). During +VT, Tr had a threefold higher GH response, whereas their blood glucose level was better maintained (P < 0.05). Basal IGFBP-1 was correlated with S(I) (P < 0.01). These data indicate that endurance training in middle-aged men increased the activity of the GH/IGF-I system and improved glucoregulation both at rest and during high-intensity endurance exercise.[1]

References

Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis. Manetta, J., Brun, J.F., Maimoun, L., Callis, A., Préfaut, C., Mercier, J. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]

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