Gene Review:
IGFBP3 - insulin-like growth factor binding protein 3
Homo sapiens
Synonyms:
BP-53, IBP-3, IBP3, IGF-binding protein 3, IGFBP-3, ...
Hankinson,
Byers,
Ross,
Herrick,
Pollak,
Wolff,
He,
Baumgartner,
Sweeney,
Ali,
Grambow,
Hill,
Zogopoulos,
Schildkraut,
Travlos,
Howard D. Strickler,
Melissa Fazzari,
Andrea Kovacs,
Carmen Isasi,
Laura A. Napolitano,
Howard Minkoff,
Stephen Gange,
Mary Young,
Gerald B. Sharp,
Robert C. Kaplan,
Mardge Cohen,
Marc J. Gunter,
Tiffany G. Harris,
Herbert Yu,
Ellie Schoenbaum,
Alan L. Landay,
Kathryn Anastos,
Guiliano,
Demark-Wahnefried,
O'dwyer,
Curtin,
Young,
Zhang,
Zhou,
Tan,
London,
Ma,
Rivarola,
Walther,
Atkin,
Gao,
Schernhammer,
Belgorosky,
Hunter,
MacCallum,
Yu,
Slattery,
Krackovitch,
Yuan,
De Souza Li,
Gómez,
Wenham,
Goodyer,
Blouin,
Shalet,
Murtaugh,
Grubber,
Manalo,
Jeffreys,
Ding,
Marks,
Shan,
Renehan,
Lillington,
Moorman,
Hoyo,
Jin,
Figueiredo,
Wilson,
- Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Ibanez de Caceres, I., Dulaimi, E., Hoffman, A.M., Al-Saleem, T., Uzzo, R.G., Cairns, P. Cancer Res. (2006)
- Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Hansel, D.E., Rahman, A., House, M., Ashfaq, R., Berg, K., Yeo, C.J., Maitra, A. Clin. Cancer Res. (2004)
- Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. Schernhammer, E.S., Hankinson, S.E., Hunter, D.J., Blouin, M.J., Pollak, M.N. Int. J. Cancer (2003)
- Erythrocytosis after renal transplantation represents an abnormality of insulin-like growth factor-I and its binding proteins. Brox, A.G., Mangel, J., Hanley, J.A., St Louis, G., Mongrain, S., Gagnon, R.F. Transplantation (1998)
- IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men. Schildkraut, J.M., Demark-Wahnefried, W., Wenham, R.M., Grubber, J., Jeffreys, A.S., Grambow, S.C., Marks, J.R., Moorman, P.G., Hoyo, C., Ali, S., Walther, P.J. Cancer Epidemiol. Biomarkers Prev. (2005)
- Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha. Zappala, G., Elbi, C., Edwards, J., Gorenstein, J., Rechler, M.M., Bhattacharyya, N. Endocrinology (2008)
- Associations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 with HIV disease progression in women. Strickler, H.D., Fazzari, M., Kovacs, A., Isasi, C., Napolitano, L.A., Minkoff, H., Gange, S., Young, M., Sharp, G.B., Kaplan, R.C., Cohen, M., Gunter, M.J., Harris, T.G., Yu, H., Schoenbaum, E., Landay, A.L., Anastos, K. J. Infect. Dis. (2008)
- Low serum levels of free and total insulin-like growth factor I (IGF-I) in patients with anorexia nervosa are not associated with increased IGF-binding protein-3 proteolysis. Støving, R.K., Flyvbjerg, A., Frystyk, J., Fisker, S., Hangaard, J., Hansen-Nord, M., Hagen, C. J. Clin. Endocrinol. Metab. (1999)
- Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white women. Slattery, M.L., Baumgartner, K.B., Byers, T., Guiliano, A., Sweeney, C., Herrick, J., Curtin, K., Murtaugh, M., Wolff, R. Cancer Causes Control (2005)
- The effect of cigarette smoking use and cessation on serum insulin-like growth factors. Renehan, A.G., Atkin, W.S., O'dwyer, S.T., Shalet, S.M. Br. J. Cancer (2004)
- Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome. Rapkin, A.J., Cedars, M., Morgan, M., Goldman, L. Fertil. Steril. (1998)
- Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis. Pedersen, N., Larsen, S., Seidelin, J.B., Nielsen, O.H. Scand. J. Gastroenterol. (2004)
- The little women of Loja--growth hormone-receptor deficiency in an inbred population of southern Ecuador. Rosenbloom, A.L., Guevara Aguirre, J., Rosenfeld, R.G., Fielder, P.J. N. Engl. J. Med. (1990)
- A month-long effect from a single injection of microencapsulated human growth hormone. Johnson, O.L., Cleland, J.L., Lee, H.J., Charnis, M., Duenas, E., Jaworowicz, W., Shepard, D., Shahzamani, A., Jones, A.J., Putney, S.D. Nat. Med. (1996)
- Induction of the growth inhibitor IGF-binding protein 3 by p53. Buckbinder, L., Talbott, R., Velasco-Miguel, S., Takenaka, I., Faha, B., Seizinger, B.R., Kley, N. Nature (1995)
- Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. London, S.J., Yuan, J.M., Travlos, G.S., Gao, Y.T., Wilson, R.E., Ross, R.K., Yu, M.C. J. Natl. Cancer Inst. (2002)
- Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls. Keay, S., Zhang, C.O., Kagen, D.I., Hise, M.K., Jacobs, S.C., Hebel, J.R., Gordon, D., Whitmore, K., Bodison, S., Warren, J.W. J. Urol. (1997)
- Insulin-like growth factor-I and -II in human benign prostatic hyperplasia: relationship with binding proteins 2 and 3 and androgens. Monti, S., Di Silverio, F., Lanzara, S., Varasano, P., Martini, C., Tosti-Croce, C., Sciarra, F. Steroids (1998)
- Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells. Gucev, Z.S., Oh, Y., Kelley, K.M., Rosenfeld, R.G. Cancer Res. (1996)
- Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. Baxter, R.C., Holman, S.R., Corbould, A., Stranks, S., Ho, P.J., Braund, W. J. Clin. Endocrinol. Metab. (1995)
- Growth Inhibitory Concentrations of Androgens Up-Regulate Insulin-Like Growth Factor Binding Protein-3 Expression via an Androgen Response Element in LNCaP Human Prostate Cancer Cells. Peng, L., Malloy, P.J., Wang, J., Feldman, D. Endocrinology (2006)
- Molecular cloning of a constitutional t(7;22) translocation associated with risk of hematological malignancy. Hill, A.S., MacCallum, P.K., Young, B.D., Lillington, D.M. Genes Chromosomes Cancer (2003)
- Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor (IGF) I, and IGF-binding protein 3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Study Group of IUGR. Leger, J., Noel, M., Limal, J.M., Czernichow, P. Pediatr. Res. (1996)
- Characterization of insulin-like growth factor binding proteins and regulation of IGFBP3 in human mesangial cells. Grellier, P., Sabbah, M., Fouqueray, B., Woodruff, K., Yee, D., Abboud, H.E., Abboud, S.L. Kidney Int. (1996)
- Characterization of the growth hormone receptor in human dermal fibroblasts and liver during development. Goodyer, C.G., Figueiredo, R.M., Krackovitch, S., De Souza Li, L., Manalo, J.A., Zogopoulos, G. Am. J. Physiol. Endocrinol. Metab. (2001)
- Anatomy of the human ovarian insulin-like growth factor system. Zhou, J., Bondy, C. Biol. Reprod. (1993)
- Evaluation of nutritional status and pathophysiology of growth retardation in patients with phenylketonuria. Dobbelaere, D., Michaud, L., Debrabander, A., Vanderbecken, S., Gottrand, F., Turck, D., Farriaux, J.P. J. Inherit. Metab. Dis. (2003)
- The role of insulin-like growth factor I components in the regulation of vitamin D. Gómez, J.M. Current pharmaceutical biotechnology. (2006)
- Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging. Waters, D.L., Yau, C.L., Montoya, G.D., Baumgartner, R.N. J. Gerontol. A Biol. Sci. Med. Sci. (2003)
- Growth and growth factors in premature infants receiving dexamethasone for bronchopulmonary dysplasia. Skinner, A.M., Battin, M., Solimano, A., Daaboul, J., Kitson, H.F. American journal of perinatology. (1997)
- Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3. Oesterreicher, S., Blum, W.F., Schmidt, B., Braulke, T., Kübler, B. J. Biol. Chem. (2005)
- Relation of insulin-like growth factor (IGF) I and IGF-binding protein 3 concentrations with intakes of fruit, vegetables, and antioxidants. Tran, C.D., Diorio, C., Bérubé, S., Pollak, M., Brisson, J. Am. J. Clin. Nutr. (2006)
- Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin. Paquette, J., Bessette, B., Ledru, E., Deal, C. Endocrinology (2007)
- Signaling through the Smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells. Relationship to transforming growth factor-beta 1 signaling. Fanayan, S., Firth, S.M., Baxter, R.C. J. Biol. Chem. (2002)
- The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. Giudice, L.C., Dsupin, B.A., Gargosky, S.E., Rosenfeld, R.G., Irwin, J.C. J. Clin. Endocrinol. Metab. (1994)
- Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma. Gui, Y., Murphy, L.J. J. Clin. Endocrinol. Metab. (2001)
- Insulin-like growth factor binding protein (IGFBP)-3-bound IGF-I and IGFBP-3-bound IGF-II in growth hormone deficiency. Belgorosky, A., Rivarola, M.A. Horm. Res. (1999)
- Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3. Storch, S., Kübler, B., Höning, S., Ackmann, M., Zapf, J., Blum, W., Braulke, T. FEBS Lett. (2001)
- Insulin-like growth factor binding protein concentration and post-translational modification in embryological fluid. Miell, J.P., Jauniaux, E., Langford, K.S., Westwood, M., White, A., Jones, J.S. Mol. Hum. Reprod. (1997)
- Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. Cohen, P., Graves, H.C., Peehl, D.M., Kamarei, M., Giudice, L.C., Rosenfeld, R.G. J. Clin. Endocrinol. Metab. (1992)
- ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. Mochizuki, S., Shimoda, M., Shiomi, T., Fujii, Y., Okada, Y. Biochem. Biophys. Res. Commun. (2004)
- Insulin-like growth factor binding protein 3 in inflammatory bowel disease. Kirman, I., Whelan, R.L., Jain, S., Nielsen, S.E., Seidelin, J.B., Nielsen, O.H. Dig. Dis. Sci. (2005)
- Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3. Fowlkes, J.L., Serra, D.M. J. Biol. Chem. (1996)
- Most of the circulating insulin-like growth factors-I and -II are present in the 150 kDa complex during human pregnancy. Gargosky, S.E., Owens, P.C., Walton, P.E., Owens, J.A., Robinson, J.S., Wallace, J.C., Ballard, F.J. J. Endocrinol. (1991)
- Insulin-like growth factors (IGFs) reduce IGF-binding protein-4 (IGFBP-4) concentration and stimulate IGFBP-3 independently of IGF receptors in human fibroblasts and epidermal cells. Neely, E.K., Rosenfeld, R.G. Endocrinology (1992)
- Expression of insulin-like growth factor and binding protein genes during nephrogenesis. Matsell, D.G., Delhanty, P.J., Stepaniuk, O., Goodyear, C., Han, V.K. Kidney Int. (1994)
- Complex formation by human insulin-like growth factor-binding protein-3 and human acid-labile subunit in growth hormone-deficient rats. Lewitt, M.S., Saunders, H., Phuyal, J.L., Baxter, R.C. Endocrinology (1994)
- EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I. Takaoka, M., Smith, C.E., Mashiba, M.K., Okawa, T., Andl, C.D., El-Deiry, W.S., Nakagawa, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Endogenous insulin-like growth factor (IGF) binding proteins cause IGF-1 resistance in cultured fibroblasts from a patient with short stature. Tollefsen, S.E., Heath-Monnig, E., Cascieri, M.A., Bayne, M.L., Daughaday, W.H. J. Clin. Invest. (1991)
- The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry. Neumann, G.M., Bach, L.A. J. Biol. Chem. (1999)
- Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. Ukkola, O., Sun, G., Bouchard, C. Diabetologia (2001)
- Identification and characterization of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases in human synovial fluid. Matsumoto, T., Gargosky, S.E., Iwasaki, K., Rosenfeld, R.G. J. Clin. Endocrinol. Metab. (1996)
- Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. Aguiar-Oliveira, M.H., Gill, M.S., de A Barretto, E.S., Alcântara, M.R., Miraki-Moud, F., Menezes, C.A., Souza, A.H., Martinelli, C.E., Pereira, F.A., Salvatori, R., Levine, M.A., Shalet, S.M., Camacho-Hubner, C., Clayton, P.E. J. Clin. Endocrinol. Metab. (1999)
- Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study. Le Marchand, L., Kolonel, L.N., Henderson, B.E., Wilkens, L.R. Cancer Epidemiol. Biomarkers Prev. (2005)
- Serum free IGF-I, total IGF-I, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels. Janssen, J.A., Stolk, R.P., Pols, H.A., Grobbee, D.E., de Jong, F.H., Lamberts, S.W. Clin. Endocrinol. (Oxf) (1998)
- Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data. Soliman, A.T., El Banna, N., Abdel Fattah, M., ElZalabani, M.M., Ansari, B.M. Metab. Clin. Exp. (1998)
- Combined human growth hormone and lactulose for prevention and treatment of multiple organ dysfunction in patients with severe chronic hepatitis B. Ding, H.G., Shan, J., Zhang, B., Ma, H.B., Zhou, L., Jin, R., Tan, Y.F., He, L.X. World J. Gastroenterol. (2005)