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Auricchio, A. et al.

Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents.

Neovascularization characterizes diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration, the most common causes of severe visual loss in the developed world. Gene transfer to the eye using adeno-associated viral (AAV) vectors is a promising new treatment for inherited and acquired ocular diseases. We used an AAV vector with rapid onset and high levels of gene expression in the retina to deliver three anti-angiogenic factors (pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-3, and endostatin) to the eyes of mice in a mouse model of retinopathy of prematurity. All three vectors inhibited ischemia-induced neovascularization.[1]

References

Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Auricchio, A., Behling, K.C., Maguire, A.M., O'Connor, E.M., Bennett, J., Wilson, J.M., Tolentino, M.J. Mol. Ther. (2002) [Pubmed]

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