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MeSH Review

Choroidal Neovascularization

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Disease relevance of Choroidal Neovascularization


High impact information on Choroidal Neovascularization


Chemical compound and disease context of Choroidal Neovascularization


Biological context of Choroidal Neovascularization


Anatomical context of Choroidal Neovascularization


Gene context of Choroidal Neovascularization


Analytical, diagnostic and therapeutic context of Choroidal Neovascularization


  1. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Blaauwgeers, H.G., Holtkamp, G.M., Rutten, H., Witmer, A.N., Koolwijk, P., Partanen, T.A., Alitalo, K., Kroon, M.E., Kijlstra, A., van Hinsbergh, V.W., Schlingemann, R.O. Am. J. Pathol. (1999) [Pubmed]
  2. Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier. Gehlbach, P., Demetriades, A.M., Yamamoto, S., Deering, T., Xiao, W.H., Duh, E.J., Yang, H.S., Lai, H., Kovesdi, I., Carrion, M., Wei, L., Campochiaro, P.A. Hum. Gene Ther. (2003) [Pubmed]
  3. Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Rasmussen, H., Chu, K.W., Campochiaro, P., Gehlbach, P.L., Haller, J.A., Handa, J.T., Nguyen, Q.D., Sung, J.U. Hum. Gene Ther. (2001) [Pubmed]
  4. Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier. Nambu, H., Nambu, R., Oshima, Y., Hackett, S.F., Okoye, G., Wiegand, S., Yancopoulos, G., Zack, D.J., Campochiaro, P.A. Gene Ther. (2004) [Pubmed]
  5. Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression. Roybal, C.N., Marmorstein, L.Y., Vander Jagt, D.L., Abcouwer, S.F. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  6. A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Qi, J.H., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., Baker, A., Anand-Apte, B. Nat. Med. (2003) [Pubmed]
  7. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. Nozaki, M., Sakurai, E., Raisler, B.J., Baffi, J.Z., Witta, J., Ogura, Y., Brekken, R.A., Sage, E.H., Ambati, B.K., Ambati, J. J. Clin. Invest. (2006) [Pubmed]
  8. Drusen complement components C3a and C5a promote choroidal neovascularization. Nozaki, M., Raisler, B.J., Sakurai, E., Sarma, J.V., Barnum, S.R., Lambris, J.D., Chen, Y., Zhang, K., Ambati, B.K., Baffi, J.Z., Ambati, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. Lambert, V., Munaut, C., Noël, A., Frankenne, F., Bajou, K., Gerard, R., Carmeliet, P., Defresne, M.P., Foidart, J.M., Rakic, J.M. FASEB J. (2001) [Pubmed]
  10. Matrix metalloproteinase-9 contributes to choroidal neovascularization. Lambert, V., Munaut, C., Jost, M., Noël, A., Werb, Z., Foidart, J.M., Rakic, J.M. Am. J. Pathol. (2002) [Pubmed]
  11. Blockade of nitric-oxide synthase reduces choroidal neovascularization. Ando, A., Yang, A., Nambu, H., Campochiaro, P.A. Mol. Pharmacol. (2002) [Pubmed]
  12. Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hangai, M., Moon, Y.S., Kitaya, N., Chan, C.K., Wu, D.Y., Peters, K.G., Ryan, S.J., Hinton, D.R. Hum. Gene Ther. (2001) [Pubmed]
  13. Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes. Murata, T., Hangai, M., Ishibashi, T., Spee, C., Gordon, E.M., Anderson, W.F., Hinton, D.R., Ryan, S.J. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  14. Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat. Yanagi, Y., Tamaki, Y., Obata, R., Muranaka, K., Homma, N., Matsuoka, H., Mano, H. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  15. Noninvasive technique for monitoring chorioretinal temperature during transpupillary thermotherapy, with a thermosensitive liposome. Miura, S., Nishiwaki, H., Ieki, Y., Hirata, Y., Kiryu, J., Honda, Y. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  16. Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development. Vinores, S.A., Xiao, W.H., Aslam, S., Shen, J., Oshima, Y., Nambu, H., Liu, H., Carmeliet, P., Campochiaro, P.A. J. Cell. Physiol. (2006) [Pubmed]
  17. Photodynamic therapy with verteporfin in mallatia leventinese. Dantas, M.A., Slakter, J.S., Negrao, S., Fonseca, R.A., Kaga, T., Yannuzzi, L.A. Ophthalmology (2002) [Pubmed]
  18. Changes in multifocal electroretinograms induced by transpupillary thermotherapy. Shimada, Y., Horiguchi, M. Arch. Ophthalmol. (2005) [Pubmed]
  19. Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization. Robinson, M.R., Baffi, J., Yuan, P., Sung, C., Byrnes, G., Cox, T.A., Csaky, K.G. Exp. Eye Res. (2002) [Pubmed]
  20. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Spilsbury, K., Garrett, K.L., Shen, W.Y., Constable, I.J., Rakoczy, P.E. Am. J. Pathol. (2000) [Pubmed]
  21. Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat. Kamizuru, H., Kimura, H., Yasukawa, T., Tabata, Y., Honda, Y., Ogura, Y. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  22. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Sakurai, E., Taguchi, H., Anand, A., Ambati, B.K., Gragoudas, E.S., Miller, J.W., Adamis, A.P., Ambati, J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  23. Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization? Cousins, S.W., Espinosa-Heidmann, D.G., Csaky, K.G. Arch. Ophthalmol. (2004) [Pubmed]
  24. Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization. Rakic, J.M., Lambert, V., Munaut, C., Bajou, K., Peyrollier, K., Alvarez-Gonzalez, M.L., Carmeliet, P., Foidart, J.M., Noël, A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  25. Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. Matsuda, S., Gomi, F., Oshima, Y., Tohyama, M., Tano, Y. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  26. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Rakic, J.M., Lambert, V., Devy, L., Luttun, A., Carmeliet, P., Claes, C., Nguyen, L., Foidart, J.M., Noël, A., Munaut, C. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  27. Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration. Guymer, R.H., Héon, E., Lotery, A.J., Munier, F.L., Schorderet, D.F., Baird, P.N., McNeil, R.J., Haines, H., Sheffield, V.C., Stone, E.M. Arch. Ophthalmol. (2001) [Pubmed]
  28. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. Lambert, V., Wielockx, B., Munaut, C., Galopin, C., Jost, M., Itoh, T., Werb, Z., Baker, A., Libert, C., Krell, H.W., Foidart, J.M., Noël, A., Rakic, J.M. FASEB J. (2003) [Pubmed]
  29. Dose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type I: implications for clinical trials. Lambert, V., Munaut, C., Carmeliet, P., Gerard, R.D., Declerck, P.J., Gils, A., Claes, C., Foidart, J.M., Noël, A., Rakic, J.M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  30. Large-spot size transpupillary thermotherapy for the treatment of occult choroidal neovascularization associated with age-related macular degeneration. Thach, A.B., Sipperley, J.O., Dugel, P.U., Sneed, S.R., Park, D.W., Cornelius, J. Arch. Ophthalmol. (2003) [Pubmed]
  31. Choroidal neovascularization in phakic eyes with anterior chamber intraocular lenses to correct high myopia. Ruiz-Moreno, J.M., de la Vega, C., Ruiz-Moreno, O., Alió, J.L. Journal of cataract and refractive surgery. (2003) [Pubmed]
  32. Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model. Das, A., Boyd, N., Jones, T.R., Talarico, N., McGuire, P.G. Arch. Ophthalmol. (2004) [Pubmed]
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