Disease relevance of Retinopathy of Prematurity

• Among the infants given placebo, those who had poor outcomes (death, bronchopulmonary dysplasia, or stage 4 retinopathy of prematurity) had lower serum inositol concentrations during days 2 through 7 than those who had good outcomes (P less than 0.01) [1].
• Abnormalities of the L-arginine/nitric oxide system have been observed in a variety of ocular diseases including glaucoma, diabetic retinopathy and retinopathy of prematurity [2].
• However, the benefit of pharmacologic doses of vitamin E given as prophylaxis against diseases believed to be related to oxygen toxicity (bronchopulmonary dysplasia, retinopathy of prematurity, and periventricular-intraventricular hemorrhage) is not clear [3].
• PURPOSE: Mutations in the NDP gene give rise to a variety of eye diseases, including classic Norrie disease (ND), X-linked exudative vitreoretinopathy (EVRX), retinal telangiectasis (Coats disease), and advanced retinopathy of prematurity (ROP) [4].
• Prolonged dexamethasone therapy reduces the incidence of cryotherapy for retinopathy of prematurity in infants of less than 1 kilogram birth weight with bronchopulmonary dysplasia [5].

High impact information on Retinopathy of Prematurity

• Lack of efficacy of light reduction in preventing retinopathy of prematurity. Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group [6].
• Retinopathy of prematurity and bilirubin [7].
• Vitamin E in retrolental fibroplasia [8].
• Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity [9].
• The requirement for the nonreceptor tyrosine kinase c-abl in the pathogenesis of retinopathy of prematurity (ROP) was examined using the mouse model for ROP and c-abl-deficient mice [10].

Chemical compound and disease context of Retinopathy of Prematurity

• Glutathione status in retinopathy of prematurity [11].
• Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity [12].
• The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity [13].
• PURPOSE: To examine a possible role for the angiotensin system in a rodent model of retinopathy of prematurity [14].
• METHODS: TSP-1 and peptides with tryptophan-rich, heparin-binding sequences and transforming growth factor (TGF)-beta1 activation sequences were evaluated in two models of retinal angiogenesis: a retinal explant assay and a rat model of retinopathy of prematurity (ROP) [15].

Biological context of Retinopathy of Prematurity

• We used an AAV vector with rapid onset and high levels of gene expression in the retina to deliver three anti-angiogenic factors (pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-3, and endostatin) to the eyes of mice in a mouse model of retinopathy of prematurity [16].
• Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity [17].
• Bilirubin levels and severe retinopathy of prematurity in infants with estimated gestational ages of 23 to 26 weeks [18].
• Identification of missense mutations in the Norrie disease gene associated with advanced retinopathy of prematurity [19].
• Disinfection of eyelid specula with chlorhexidine gluconate (Hibiclens) after examinations for retinopathy of prematurity [20].

Anatomical context of Retinopathy of Prematurity

• Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity [21].
• We investigated whether inhibition of platelet-derived growth factor (PDGF) receptor tyrosine kinase activity would affect pericyte viability, vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor-2 (VEGFR-2) expression and angiogenesis in a model of retinopathy of prematurity (ROP) [22].
• Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity [23].
• This study examines the glutathione status of red blood cells in patients with retinopathy of prematurity (ROP) both in vivo and after an in vitro oxidative challenge [11].
• Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity [24].

Gene context of Retinopathy of Prematurity

• Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity [25].
• HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin [26].
• PURPOSE: To determine whether SB-267268, a nonpeptidic antagonist of the alpha(v)beta3 and alpha(v)beta5 integrins, attenuates angiogenesis in a murine model of retinopathy of prematurity (ROP) and alters the expression of vascular endothelial growth factor (VEGF) and its second receptor (VEGF-R2) [27].
• We induced retinopathy in tumor necrosis factor receptor-deficient mice (TNFR-) in order to examine the role TNF-alpha plays in the pathogenesis of retinopathy of prematurity [28].
• In a mouse model for retinopathy of prematurity, adam15(-/-) mice had a major reduction in neovascularization compared to wild-type controls [29].

Analytical, diagnostic and therapeutic context of Retinopathy of Prematurity

• Large parenteral doses of vitamin E have been purported to protect premature infants exposed to oxygen-enriched environments and mechanical ventilation from the complications of retrolental fibroplasia and bronchopulmonary dysplasia [30].
• OBJECTIVE: We conducted a meta-analysis of the published randomized clinical trials of vitamin E prophylaxis designed to reduce retinopathy of prematurity (ROP) to determine whether increased serum concentrations of vitamin E reduced the incidence of severe, threshold (Stage 3+) ROP in the very low birth weight (VLBW) infant subset [31].
• The effect of vitamin E administered during the acute phase of therapy for respiratory distress syndrome (RDS) on the development of retinopathy of prematurity (ROP) was evaluated in a randomized double-masked study [32].
• OBJECTIVE: To evaluate the effectiveness of 70% isopropyl alcohol swabs in disinfecting eyelid speculums after examination for retinopathy of prematurity [33].
• Previously reported clinical trials on the role of vitamin E in the prevention of retinopathy of prematurity have given conflicting results [34].

References