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Gerard, N.P. et al.

Complement in allergy and asthma.

The complement system is a vital link between innate and adaptive immunity. Recently, several investigators have implicated the complement anaphylatoxins C3a and C5a as potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and asthma. Thus, complement activation may synergize with classical IgE mediated responses, and inhibition of complement may prove therapeutic.[1]

References

Complement in allergy and asthma. Gerard, N.P., Gerard, C. Curr. Opin. Immunol. (2002) [Pubmed]

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