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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis.

Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of multiple sclerosis ( MS). It has to be released from its cell membrane-bound precursor by proteolytic cleavage. This is mainly performed by a member of the ADAM (a disintegrin and metalloproteinase) family of enzymes, TNF-alpha-converting enzyme (TACE, ADAM 17). In a longitudinal study on 11 relapsing-remitting MS patients, we qualitatively determined mRNA expression of TNF-alpha and TACE in peripheral blood mononuclear cells (PBMCs) without ex vivo stimulation. mRNA expression was related to disease activity as assessed by monthly gadolinium (Gd)-enhanced brain magnetic resonance imaging (MRI). Patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new Gd-enhancing lesions per scan one month following PBMC sampling.[1]

References

  1. TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis. Seifert, T., Kieseier, B.C., Ropele, S., Strasser-Fuchs, S., Quehenberger, F., Fazekas, F., Hartung, H.P. Mult. Scler. (2002) [Pubmed]
 
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