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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bexarotene is a new treatment option for lymphomatoid papulosis.

BACKGROUND: Lymphomatoid papulosis (LyP) is a clonal T cell proliferation with large cell histology, a chronic course, and an increased risk of lymphoma. Bexarotene (Targretin) is an RXR-selective retinoid (rexinoid) approved for the cutaneous manifestations of cutaneous T cell lymphoma. OBJECTIVE: To determine whether bexarotene is effective in treating LyP. METHODS: Ten patients with chronic and symptomatic LyP were prospectively treated with oral (n = 3) or topical gel (n = 7) formulations of bexarotene. RESULTS: A favorable response to bexarotene treatment with decreased numbers or duration of lesions was seen in all with objective responses in 8 patients. CONCLUSIONS: Bexarotene may be an effective palliative treatment for LyP, warranting further controlled studies.[1]


  1. Bexarotene is a new treatment option for lymphomatoid papulosis. Krathen, R.A., Ward, S., Duvic, M. Dermatology (Basel) (2003) [Pubmed]
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