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MeSH Review

Palliative Care

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Disease relevance of Palliative Care


Psychiatry related information on Palliative Care


High impact information on Palliative Care


Chemical compound and disease context of Palliative Care


Biological context of Palliative Care


Anatomical context of Palliative Care


Associations of Palliative Care with chemical compounds

  • PATIENTS AND METHODS: Patients in international palliative care clinics with pain requiring initiation of strong opioids were randomly assigned to receive methadone (7.5 mg orally every 12 hours and 5 mg every 4 hours as needed) or morphine (15 mg sustained release every 12 hours and 5 mg every 4 hours as needed) [28].
  • In this report, we review the use of methylphenidate in the palliative care of patients with cancer [29].
  • Oxaliplatin may be a palliative treatment option for this patient population, and evaluation in combination regimens is warranted [30].
  • The use of radiolabelled metaiodobenzylguanidine (MIBG) and 111In octreotide as potential therapeutic agents has been explored and may be potentially useful in palliative care [31].
  • Our results emphasise once again the marked efficacy and low rate of complications associated with oral and parenteral analgesic therapy as the mainstay of pain treatment in the palliative care of patients with advanced cancer [32].

Gene context of Palliative Care

  • Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma [33].
  • The anti-AChE efficacy of bis(7)-tacrine was quite similar following an oral or i.p. administration, but tacrine showed much lower efficacy when administered orally than when given i.p. These findings suggest bis(7)-tacrine, a highly potent and selective inhibitor of AChE, can probably be used as an improved drug in the palliative treatment of AD [34].
  • According to preliminary data, this study demonstrates that intracavitary administration of cytokines, including IL-2, IFN alpha and -beta, is a new well-tolerated palliative therapy for malignant effusions, with an efficacy substantially comparable to that described with the most commonly used treatments with tetracyclines or cytostatic agents [35].
  • In patients who underwent palliative surgery, the serum MCP-1 level significantly decreased postoperatively, whereas in patients who underwent curative surgery the serum MCP-1 level tended to increase [36].
  • Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population [37].

Analytical, diagnostic and therapeutic context of Palliative Care


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  2. Treatment of recurrent gliomas with eflornithine. Levin, V.A., Prados, M.D., Yung, W.K., Gleason, M.J., Ictech, S., Malec, M. J. Natl. Cancer Inst. (1992) [Pubmed]
  3. Patients with myelodysplastic syndromes benefit from palliative therapy with amifostine, pentoxifylline, and ciprofloxacin with or without dexamethasone. Raza, A., Qawi, H., Lisak, L., Andric, T., Dar, S., Andrews, C., Venugopal, P., Gezer, S., Gregory, S., Loew, J., Robin, E., Rifkin, S., Hsu, W.T., Huang, R.W. Blood (2000) [Pubmed]
  4. Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. Leonard, R., Hardy, J., van Tienhoven, G., Houston, S., Simmonds, P., David, M., Mansi, J. J. Clin. Oncol. (2001) [Pubmed]
  5. Prospective randomized trial of intrapleural bleomycin versus interferon alfa-2b via ultrasound-guided small-bore chest tube in the palliative treatment of malignant pleural effusions. Sartori, S., Tassinari, D., Ceccotti, P., Tombesi, P., Nielsen, I., Trevisani, L., Abbasciano, V. J. Clin. Oncol. (2004) [Pubmed]
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  7. A new estrogen receptor antagonist--an overview of available data. Jones, S.E. Breast Cancer Res. Treat. (2002) [Pubmed]
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  9. The commonality and synchronicity of mental health nurses and palliative care nurses: closer than you think? Part two. Cutcliffe, J.R., Black, C., Hanson, E., Goward, P. Journal of psychiatric and mental health nursing. (2001) [Pubmed]
  10. Modafinil: a gift to portmanteau. Cox, J.M., Pappagallo, M. The American journal of hospice & palliative care. (2001) [Pubmed]
  11. JAMA patient page. Palliative care. Stevens, L.M. JAMA (2002) [Pubmed]
  12. The Pain Relief Promotion Act of 1999: a serious threat to palliative care. Orentlicher, D., Caplan, A. JAMA (2000) [Pubmed]
  13. Five-day oral etoposide treatment for advanced small-cell lung cancer: randomized comparison with intravenous chemotherapy. Souhami, R.L., Spiro, S.G., Rudd, R.M., Ruiz de Elvira, M.C., James, L.E., Gower, N.H., Lamont, A., Harper, P.G. J. Natl. Cancer Inst. (1997) [Pubmed]
  14. Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma--a randomized controlled trial. Lin, D.Y., Liaw, Y.F., Lee, T.Y., Lai, C.M. Gastroenterology (1988) [Pubmed]
  15. Discussing palliative care with patients. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Lo, B., Quill, T., Tulsky, J. Ann. Intern. Med. (1999) [Pubmed]
  16. Tamoxifen flare in advanced endometrial carcinoma. Brooks, B.J., Lippman, M.E. J. Clin. Oncol. (1985) [Pubmed]
  17. Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. Protocol 19 Aredia Breast Cancer Study Group. Hortobagyi, G.N., Theriault, R.L., Lipton, A., Porter, L., Blayney, D., Sinoff, C., Wheeler, H., Simeone, J.F., Seaman, J.J., Knight, R.D., Heffernan, M., Mellars, K., Reitsma, D.J. J. Clin. Oncol. (1998) [Pubmed]
  18. Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer. Faulds, D., Balfour, J.A., Chrisp, P., Langtry, H.D. Drugs (1991) [Pubmed]
  19. Pharmacokinetics of rhenium-186 after administration of rhenium-186-HEDP to patients with bone metastases. de Klerk, J.M., van Dijk, A., van het Schip, A.D., Zonnenberg, B.A., van Rijk, P.P. J. Nucl. Med. (1992) [Pubmed]
  20. Iodine-131-labeled diphosphonates for palliative treatment of bone metastases: II. Preliminary clinical results with iodine-131 BDP3. Eisenhut, M., Berberich, R., Kimmig, B., Oberhausen, E. J. Nucl. Med. (1986) [Pubmed]
  21. Oral acyclovir, palliative therapy for genital herpes: will it change the epidemiology? Guinan, M.E. Sexually transmitted diseases. (1985) [Pubmed]
  22. Clinical uses of antiprogestogens. Van Look, P.F., von Hertzen, H. Hum. Reprod. Update (1995) [Pubmed]
  23. Ki-67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations. Shepherd, N.A., Richman, P.I., England, J. J. Pathol. (1988) [Pubmed]
  24. Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical support. Raoul, J.L., Guyader, D., Bretagne, J.F., Duvauferrier, R., Bourguet, P., Bekhechi, D., Deugnier, Y.M., Gosselin, M. J. Nucl. Med. (1994) [Pubmed]
  25. Radiofrequency catheter ablation of atrial tachycardias. Poty, H., Saoudi, N., Haissaguerre, M., Daou, A., Clementy, J., Letac, B. Am. Heart J. (1996) [Pubmed]
  26. A case series of inferior vena cava stenting for lower limb oedema in palliative care. McGee, H., Maudgil, D., Tookman, A., Kurowska, A., Watkinson, A.F. Palliative medicine. (2004) [Pubmed]
  27. Recurrent and metastatic clivus chordoma: systemic palliative therapy retards disease progression. Schönegger, K., Gelpi, E., Prayer, D., Dieckmann, K., Matula, C., Hassler, M., Hainfellner, J.A., Marosi, C. Anticancer Drugs (2005) [Pubmed]
  28. Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. Bruera, E., Palmer, J.L., Bosnjak, S., Rico, M.A., Moyano, J., Sweeney, C., Strasser, F., Willey, J., Bertolino, M., Mathias, C., Spruyt, O., Fisch, M.J. J. Clin. Oncol. (2004) [Pubmed]
  29. Palliative uses of methylphenidate in patients with cancer: a review. Rozans, M., Dreisbach, A., Lertora, J.J., Kahn, M.J. J. Clin. Oncol. (2002) [Pubmed]
  30. Activity of oxaliplatin in patients with relapsed or cisplatin-refractory germ cell cancer: a study of the German Testicular Cancer Study Group. Kollmannsberger, C., Rick, O., Derigs, H.G., Schleucher, N., Schöffski, P., Beyer, J., Schoch, R., Sayer, H.G., Gerl, A., Kuczyk, M., Spott, C., Kanz, L., Bokemeyer, C. J. Clin. Oncol. (2002) [Pubmed]
  31. Drug therapy alternatives in the treatment of thyroid cancer. O'Doherty, M.J., Coakley, A.J. Drugs (1998) [Pubmed]
  32. Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study. Zech, D.F., Grond, S., Lynch, J., Hertel, D., Lehmann, K.A. Pain (1995) [Pubmed]
  33. Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma. Hagan, M., Yacoub, A., Dent, P. Clin. Cancer Res. (2004) [Pubmed]
  34. Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE. Wang, H., Carlier, P.R., Ho, W.L., Wu, D.C., Lee, N.T., Li, C.P., Pang, Y.P., Han, Y.F. Neuroreport (1999) [Pubmed]
  35. Intracavitary therapy of neoplastic effusions with cytokines: comparison among interferon alpha, beta and interleukin-2. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Tisi, E., Angeli, M., Rizzi, A. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. (1995) [Pubmed]
  36. Profile of monocyte chemoattractant protein-1 circulating levels in gastric cancer patients. Tonouchi, H., Miki, C., Tanaka, K., Kusunoki, M. Scand. J. Gastroenterol. (2002) [Pubmed]
  37. Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population. Smith, H.S., Baird, W. The American journal of hospice & palliative care. (2003) [Pubmed]
  38. Malignant gastroduodenal obstructions: treatment by means of a covered expandable metallic stent-initial experience. Jung, G.S., Song, H.Y., Kang, S.G., Huh, J.D., Park, S.J., Koo, J.Y., Cho, Y.D. Radiology. (2000) [Pubmed]
  39. Percutaneous sclerotherapy of lymphangiomas. Molitch, H.I., Unger, E.C., Witte, C.L., vanSonnenberg, E. Radiology. (1995) [Pubmed]
  40. Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer. Sohda, M., Ishikawa, H., Masuda, N., Kato, H., Miyazaki, T., Nakajima, M., Fukuchi, M., Manda, R., Fukai, Y., Sakurai, H., Kuwano, H. Int. J. Cancer (2004) [Pubmed]
  41. Combined radiotherapy and chemotherapy (cisplatin and 5-fluorouracil) as palliative treatment for localized unresectable or adjuvant treatment for resected pancreatic adenocarcinoma: results of a feasibility study. André, T., Balosso, J., Louvet, C., Hannoun, L., Houry, S., Huguier, M., Colonna, M., Lotz, J.P., De Gramont, A., Bellaïche, A., Parc, R., Touboul, E., Izrael, V. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  42. High-dose intravenous pamidronate for metastatic bone pain. Purohit, O.P., Anthony, C., Radstone, C.R., Owen, J., Coleman, R.E. Br. J. Cancer (1994) [Pubmed]
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