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McMahon, C.D. et al.

McMahon, Popovic, Oldham, Jeanplong, Smith, Kambadur, Sharma, Maxwell, Bass,

Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension.

Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the myostatin gene [Mstn(-/-)] would lose less muscle mass than wild-type mice during 7 days of hindlimb suspension (HS). Male Mstn(-/-) and wild-type (C57) mice were subjected to HS or served as ground-based controls (n = 6/group). Wild-type mice lost 8% of body mass and approximately 13% of wet mass from biceps femoris, quadriceps femoris, and soleus, whereas the mass of extensor digitorum longus (EDL) was unchanged after HS. Unexpectedly, Mstn(-/-) mice lost more body (13%, P < 0.05) and quadriceps femoris (17%, P < 0.05) mass than wild-type mice and lost 33% of EDL mass (P < 0.01) after HS. Protein expression of myostatin in biceps femoris and quadriceps femoris was not altered, whereas expression of MyoD, Myf-5, and myogenin increased in wild-type mice and tended to decrease in muscles of Mstn(-/-) mice. These data suggest that HS induced myogenesis in wild-type mice to counter atrophy, whereas myogenesis was not induced in Mstn(-/-) mice, thereby resulting in a greater loss of muscle mass.[1]

References

Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension. McMahon, C.D., Popovic, L., Oldham, J.M., Jeanplong, F., Smith, H.K., Kambadur, R., Sharma, M., Maxwell, L., Bass, J.J. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]

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