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MeSH Review

Quadriceps Muscle

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Disease relevance of Quadriceps Muscle


Psychiatry related information on Quadriceps Muscle

  • The aim of the study was to investigate the effects of oral L-carnitine supplementation on pain (VAS scale), tenderness (pain thresholds) and CK release induced by a 20-min eccentric effort of the quadriceps muscle [6].
  • METHODS: The maximal isometric voluntary strength and fatigability were determined in hand-grip and quadriceps muscles from nine male COPD patients (FEV(1) 30-50% predicted) and control subjects matched for fat-free mass (FFM), physical activity level and age [7].

High impact information on Quadriceps Muscle

  • In additional studies, vastus lateralis muscle was obtained by percutaneous biopsy during basal and insulin-stimulated conditions for assay of hexokinase and citrate synthase, and for immunohistochemical labeling of Glut 4 [8].
  • HKII contributes with about one-third of total HK activity in a supernatant of human vastus lateralis muscle [9].
  • Insulin receptor function and glycogen synthase (GS) activity and expression were examined in biopsies of vastus lateralis muscle [10].
  • Analysis of biopsies of quadriceps muscle from 19 NIDDM patients and 19 control subjects showed in the basal state a 30% decrease (P < 0.005) in total GS activity and a 38% decrease (P < 0.001) in GS mRNA/microgram DNA in NIDDM patients, whereas the GS protein level was normal [11].
  • Low-intensity exercise was not associated with a change in muscle (vastus lateralis) carnitine metabolism [12].

Chemical compound and disease context of Quadriceps Muscle


Biological context of Quadriceps Muscle


Anatomical context of Quadriceps Muscle

  • Therefore, an elevated corticosteroid production did not account for the wasting of body fat, lean body mass, skeletal muscle proteins, or decreased RNA activity in quadriceps muscles from tumor-bearing animals, although such muscles were sensitive to physiologic doses of injected hydrocortisone (20 micrograms/day) [23].
  • Histochemical analysis showed co-localization of LacZ and dystrophin expression in 5% of soleus and quadriceps muscle fibres and in 4% of heart myocytes of two of seven 8-week-old treated mdx mice [24].
  • Human satellite cells were isolated from the quadriceps muscles of three CDM fetuses with different clinical severity [25].
  • Fractional muscle protein synthesis was determined by measuring the increment of 13C leucine in mixed skeletal muscle protein obtained by needle biopsy from the quadriceps muscle during a primed-continuous infusion of L-(1-13C) leucine [26].
  • The dose-response characteristics of several glucose-utilizing tissues (brain, heart, white adipose tissue, brown adipose tissue, and quadriceps muscle) to a single injection of insulin have been compared in control mice and mice made obese with a single injection of gold thioglucose (GTG) [27].

Associations of Quadriceps Muscle with chemical compounds

  • As a marker of insulin action, the percentage of total glycogen synthase present in the I form (glucose-6-phosphate independent) was measured in quadriceps muscle biopsies [28].
  • We have compared the capillary density and muscle fiber type of musculus vastus lateralis with in vivo insulin action determined by the euglycemic clamp (M value) in 23 Caucasians and 41 Pima Indian nondiabetic men [29].
  • In group A, vastus lateralis white muscle, which contained predominantly fast glycolytic fibers, showed a significant increase in protein catabolic rates compared with pair fed controls (0.95 +/- 0.05 nmol tyrosine h-1 vs. 0.86 +/- 0.04; P less than 0.05) [30].
  • Confocal laser-scanning and digital fluorescence imaging microscopy were used to quantify the mitochondrial autofluorescence changes of NAD(P)H and flavoproteins in unfixed saponin-permeabilized myofibers from mice quadriceps muscle tissue [31].
  • Here we report increases in vastus lateralis muscle mitochondrial ATP production capacity (32-42%) in healthy humans (P < 0.01) i.v. infused with insulin (1.5 milliunits/kg of fat-free mass per min) while clamping glucose, amino acids, glucagon, and growth hormone [32].

Gene context of Quadriceps Muscle

  • Biopsy of vastus lateralis muscle was used to measure cytochrome c oxidase (COX) enzyme activity and UCP2 content [33].
  • We have confirmed that a 10-fold increase in UCP3 mRNA levels occurs in rat quadriceps muscle between 12 and 24 h of food removal [34].
  • CONCLUSION: In sedentary, clinically stable maintenance hemodialysis patients as compared to sedentary normal individuals, the mRNA levels for IGF-IEa, IGF-II, and the IGF-I receptor are decreased in vastus lateralis muscle [35].
  • Unexpectedly, Mstn(-/-) mice lost more body (13%, P < 0.05) and quadriceps femoris (17%, P < 0.05) mass than wild-type mice and lost 33% of EDL mass (P < 0.01) after HS [36].
  • In addition, radiographs of mice injected with hBMP-2 showed that much of the quadriceps muscle had undergone mineralization by day 14 [37].

Analytical, diagnostic and therapeutic context of Quadriceps Muscle

  • Subjects received an oral glucose tolerance test (OGTT) and 120-min euglycemic insulin (80 mU/m2 per min) clamp with 3-[3H]glucose/vastus lateralis muscle biopsies to quantitate rates of insulin-mediated whole-body glucose disposal (Rd) and intramyocellular LCFA-CoAs before and after acipimox (250 mg every 6 h for 7 days) [38].
  • The percentage of IR-RNA molecules without exon 11, encoding the high-affinity isoform, was determined by cDNA-mediated PCR amplification of RNA extracts from the quadriceps femoris muscle of healthy control subjects (n = 9) and NIDDM patients (n = 7) [39].
  • Under local anesthesia, approximately 1 g of vastus lateralis muscle was obtained from six healthy subjects before and 60 min after ingestion of a 75-g glucose load [40].
  • To accomplish this, we used the glucose clamp technique with isotopic determination of glucose disposal and indirect calorimetry for measuring the pathways of glucose metabolism, and vastus lateralis muscle biopsies to determine the effects of insulin on glycogen synthase and PDH activities [41].
  • 2. HDC activity in the quadriceps femoris muscle was markedly elevated following contractions evoked by even a few minutes of direct electrical stimulation, peaking at 8-12 h following contraction lasting 10 min, and gradually decreasing during the 24 h following contraction [42].


  1. Diagnosis of susceptibility to malignant hyperthermia by use of a metabolic test. Anetseder, M., Hager, M., Müller, C.R., Roewer, N. Lancet (2002) [Pubmed]
  2. Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Garvey, W.T., Maianu, L., Hancock, J.A., Golichowski, A.M., Baron, A. Diabetes (1992) [Pubmed]
  3. Effect of pulmonary rehabilitation on quadriceps fatiguability during exercise. Mador, M.J., Kufel, T.J., Pineda, L.A., Steinwald, A., Aggarwal, A., Upadhyay, A.M., Khan, M.A. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  4. Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus. Hansen, T., Bjørbaek, C., Vestergaard, H., Grønskov, K., Bak, J.F., Pedersen, O. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  5. Ischaemic heart disease, skeletal muscle fibres and exercise capacity. Karlsson, J., Diamant, B., Folkers, K., Aström, H., Gunnes, S., Liska, J., Semb, B. Eur. Heart J. (1992) [Pubmed]
  6. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Giamberardino, M.A., Dragani, L., Valente, R., Di Lisa, F., Saggini, R., Vecchiet, L. International journal of sports medicine. (1996) [Pubmed]
  7. Skeletal muscle contractility is preserved in COPD patients with normal fat-free mass. Degens, H., Sanchez Horneros, J.M., Heijdra, Y.F., Dekhuijzen, P.N., Hopman, M.T. Acta Physiol. Scand. (2005) [Pubmed]
  8. The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. Kelley, D.E., Mintun, M.A., Watkins, S.C., Simoneau, J.A., Jadali, F., Fredrickson, A., Beattie, J., Thériault, R. J. Clin. Invest. (1996) [Pubmed]
  9. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. Vestergaard, H., Bjørbaek, C., Hansen, T., Larsen, F.S., Granner, D.K., Pedersen, O. J. Clin. Invest. (1995) [Pubmed]
  10. Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy. Vestergaard, H., Klein, H.H., Hansen, T., Müller, J., Skovby, F., Bjørbaek, C., Røder, M.E., Pedersen, O. J. Clin. Invest. (1995) [Pubmed]
  11. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. Vestergaard, H., Lund, S., Larsen, F.S., Bjerrum, O.J., Pedersen, O. J. Clin. Invest. (1993) [Pubmed]
  12. Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state. Hiatt, W.R., Regensteiner, J.G., Wolfel, E.E., Ruff, L., Brass, E.P. J. Clin. Invest. (1989) [Pubmed]
  13. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. Andersen, P.H., Lund, S., Vestergaard, H., Junker, S., Kahn, B.B., Pedersen, O. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  14. Expression and carbonylation of creatine kinase in the quadriceps femoris muscles of patients with chronic obstructive pulmonary disease. Barreiro, E., Gea, J., Matar, G., Hussain, S.N. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  15. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. Barreiro, E., Gea, J., Corominas, J.M., Hussain, S.N. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  16. No correlation between changes in fatty acid-binding protein content and fatty acid oxidation capacity of rat tissues in experimental diabetes. Veerkamp, J.H., Van Moerkerk, H.T., Van den Born, J. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  17. Pulmonary injury follows systemic inflammatory reaction in infrarenal aortic surgery. Adembri, C., Kastamoniti, E., Bertolozzi, I., Vanni, S., Dorigo, W., Coppo, M., Pratesi, C., De Gaudio, A.R., Gensini, G.F., Modesti, P.A. Crit. Care Med. (2004) [Pubmed]
  18. Reduced muscle redox capacity after endurance training in patients with chronic obstructive pulmonary disease. Rabinovich, R.A., Ardite, E., Troosters, T., Carbó, N., Alonso, J., Gonzalez de Suso, J.M., Vilaró, J., Barberà, J.A., Polo, M.F., Argilés, J.M., Fernandez-Checa, J.C., Roca, J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  19. Metabolic enzyme activity in the quadriceps femoris muscle in patients with severe chronic obstructive pulmonary disease. Jakobsson, P., Jorfeldt, L., Henriksson, J. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  20. Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Agustí, A.G., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., Busquets, X. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  21. CAPON expression in skeletal muscle is regulated by position, repair, NOS activity, and dystrophy. Ségalat, L., Grisoni, K., Archer, J., Vargas, C., Bertrand, A., Anderson, J.E. Exp. Cell Res. (2005) [Pubmed]
  22. Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion. Carroll, C.C., Fluckey, J.D., Williams, R.H., Sullivan, D.H., Trappe, T.A. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  23. Tumor-host wasting not explained by adrenal hyperfunction in tumor-bearing animals. Svaninger, G., Gelin, J., Lundholm, K. J. Natl. Cancer Inst. (1987) [Pubmed]
  24. Transplacental injection of somite-derived cells in mdx mouse embryos for the correction of dystrophin deficiency. Torrente, Y., D'Angelo, M.G., Li, Z., Del Bo, R., Corti, S., Mericskay, M., DeLiso, A., Fassati, A., Paulin, D., Comi, G.P., Scarlato, G., Bresolin, N. Hum. Mol. Genet. (2000) [Pubmed]
  25. Defective satellite cells in congenital myotonic dystrophy. Furling, D., Coiffier, L., Mouly, V., Barbet, J.P., St Guily, J.L., Taneja, K., Gourdon, G., Junien, C., Butler-Browne, G.S. Hum. Mol. Genet. (2001) [Pubmed]
  26. Mechanism of muscle wasting in myotonic dystrophy. Griggs, R.C., Jozefowicz, R., Kingston, W., Nair, K.S., Herr, B.E., Halliday, D. Ann. Neurol. (1990) [Pubmed]
  27. Insulin response in individual tissues of control and gold thioglucose-obese mice in vivo with [1-14C]2-deoxyglucose. Cooney, G.J., Astbury, L.D., Williams, P.F., Caterson, I.D. Diabetes (1987) [Pubmed]
  28. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. Evans, D.J., Murray, R., Kissebah, A.H. J. Clin. Invest. (1984) [Pubmed]
  29. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. Lillioja, S., Young, A.A., Culter, C.L., Ivy, J.L., Abbott, W.G., Zawadzki, J.K., Yki-Järvinen, H., Christin, L., Secomb, T.W., Bogardus, C. J. Clin. Invest. (1987) [Pubmed]
  30. Increased muscle protein catabolism caused by carbon tetrachloride hepatic injury in rats. Weber, F.L., Macechko, P.T., Kelson, S.R., Karajiannis, E., Hassan, M.O. Gastroenterology (1992) [Pubmed]
  31. Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers. Kuznetsov, A.V., Mayboroda, O., Kunz, D., Winkler, K., Schubert, W., Kunz, W.S. J. Cell Biol. (1998) [Pubmed]
  32. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Stump, C.S., Short, K.R., Bigelow, M.L., Schimke, J.M., Nair, K.S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  33. Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization. Simoneau, J.A., Kelley, D.E., Neverova, M., Warden, C.H. FASEB J. (1998) [Pubmed]
  34. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Weigle, D.S., Selfridge, L.E., Schwartz, M.W., Seeley, R.J., Cummings, D.E., Havel, P.J., Kuijper, J.L., BeltrandelRio, H. Diabetes (1998) [Pubmed]
  35. Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients. Wang, H., Casaburi, R., Taylor, W.E., Aboellail, H., Storer, T.W., Kopple, J.D. Kidney Int. (2005) [Pubmed]
  36. Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension. McMahon, C.D., Popovic, L., Oldham, J.M., Jeanplong, F., Smith, H.K., Kambadur, R., Sharma, M., Maxwell, L., Bass, J.J. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  37. A gene expression profile for endochondral bone formation: oligonucleotide microarrays establish novel connections between known genes and BMP-2-induced bone formation in mouse quadriceps. Clancy, B.M., Johnson, J.D., Lambert, A.J., Rezvankhah, S., Wong, A., Resmini, C., Feldman, J.L., Leppanen, S., Pittman, D.D. Bone (2003) [Pubmed]
  38. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Bajaj, M., Suraamornkul, S., Romanelli, A., Cline, G.W., Mandarino, L.J., Shulman, G.I., DeFronzo, R.A. Diabetes (2005) [Pubmed]
  39. Differences in the ratio of RNA encoding two isoforms of the insulin receptor between control and NIDDM patients. The RNA variant without Exon 11 predominates in both groups. Norgren, S., Zierath, J., Galuska, D., Wallberg-Henriksson, H., Luthman, H. Diabetes (1993) [Pubmed]
  40. Glucose ingestion causes GLUT4 translocation in human skeletal muscle. Goodyear, L.J., Hirshman, M.F., Napoli, R., Calles, J., Markuns, J.F., Ljungqvist, O., Horton, E.S. Diabetes (1996) [Pubmed]
  41. Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus. Mandarino, L.J., Consoli, A., Kelley, D.E., Reilly, J.J., Nurjhan, N. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  42. Induction of histidine decarboxylase in skeletal muscle in mice by electrical stimulation, prolonged walking and interleukin-1. Endo, Y., Tabata, T., Kuroda, H., Tadano, T., Matsushima, K., Watanabe, M. J. Physiol. (Lond.) (1998) [Pubmed]
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