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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Plant defense: one post, multiple guards?!

Arabidopsis RIN4 is a key bacterial virulence target that is guarded by the resistance (R) protein RPM1. Two recent studies suggest that another R protein, RPS2, also guards RIN4. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 alter this key protein. R proteins RPM1 and RPS2 recognize the altered status and initiate a defense-signaling response. The guard hypothesis is in![1]


  1. Plant defense: one post, multiple guards?! Marathe, R., Dinesh-Kumar, S.P. Mol. Cell (2003) [Pubmed]
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