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Gene Review

RPS2  -  disease resistance protein RPS2

Arabidopsis thaliana

Synonyms: DISEASE RESISTANCE PROTEIN RPS2, F20B18.200, F20B18_200
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Disease relevance of RPS2


High impact information on RPS2


Chemical compound and disease context of RPS2


Biological context of RPS2


Anatomical context of RPS2


Associations of RPS2 with chemical compounds

  • The data presented indicate that PA is a positive regulator of RPM1- or RPS2-mediated disease resistance signalling, and that the biphasic PA production may be a conserved feature of signalling induced by the coiled-coil nucleotide binding domain leucine-rich repeat class of resistance proteins [14].
  • In addition to negatively regulating RPS2 activity, RIN4 is also a target of AvrRpt2, a Cys protease and cognate bacterial effector protein of RPS2 [3].
  • The type III effector AvrRpt2 is a cysteine protease that is autoprocessed inside the host cell where it activates RPS2 by causing RIN4 disappearance [15].
  • In salicylic acid-pretreated RPS2 seedlings, avrRpt2 transcript was produced after dex treatment [16].
  • Depolarization and electrolyte leakage were inhibited in RPS2 plants by the calcium channel blocker LaCl(3), highly correlating these events and suggesting that Ca(2+) entry into cells is required for both [16].

Other interactions of RPS2

  • Therefore, we suggest that RPS2 initiates signaling based upon perception of RIN4 disappearance rather than direct recognition of AvrRpt2 [1].


  1. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Axtell, M.J., Staskawicz, B.J. Cell (2003) [Pubmed]
  2. The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N. Lawrence, G.J., Finnegan, E.J., Ayliffe, M.A., Ellis, J.G. Plant Cell (1995) [Pubmed]
  3. Molecular basis for the RIN4 negative regulation of RPS2 disease resistance. Day, B., Dahlbeck, D., Huang, J., Chisholm, S.T., Li, D., Staskawicz, B.J. Plant Cell (2005) [Pubmed]
  4. The Erwinia amylovora avrRpt2EA gene contributes to virulence on pear and AvrRpt2EA is recognized by Arabidopsis RPS2 when expressed in pseudomonas syringae. Zhao, Y., He, S.Y., Sundin, G.W. Mol. Plant Microbe Interact. (2006) [Pubmed]
  5. Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Mackey, D., Belkhadir, Y., Alonso, J.M., Ecker, J.R., Dangl, J.L. Cell (2003) [Pubmed]
  6. The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats. Mindrinos, M., Katagiri, F., Yu, G.L., Ausubel, F.M. Cell (1994) [Pubmed]
  7. RPS2 of Arabidopsis thaliana: a leucine-rich repeat class of plant disease resistance genes. Bent, A.F., Kunkel, B.N., Dahlbeck, D., Brown, K.L., Schmidt, R., Giraudat, J., Leung, J., Staskawicz, B.J. Science (1994) [Pubmed]
  8. HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Takahashi, A., Casais, C., Ichimura, K., Shirasu, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Disease resistance gene homologs correlate with disease resistance loci of Arabidopsis thaliana. Speulman, E., Bouchez, D., Holub, E.B., Beynon, J.L. Plant J. (1998) [Pubmed]
  10. Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2. Tao, Y., Yuan, F., Leister, R.T., Ausubel, F.M., Katagiri, F. Plant Cell (2000) [Pubmed]
  11. Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1. Leister, R.T., Ausubel, F.M., Katagiri, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response. Kawasaki, T., Nam, J., Boyes, D.C., Holt, B.F., Hubert, D.A., Wiig, A., Dangl, J.L. Plant J. (2005) [Pubmed]
  13. A resistance gene product of the nucleotide binding site -- leucine rich repeats class can form a complex with bacterial avirulence proteins in vivo. Leister, R.T., Katagiri, F. Plant J. (2000) [Pubmed]
  14. Phospholipase-dependent signalling during the AvrRpm1- and AvrRpt2-induced disease resistance responses in Arabidopsis thaliana. Andersson, M.X., Kourtchenko, O., Dangl, J.L., Mackey, D., Ellerström, M. Plant J. (2006) [Pubmed]
  15. The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Kim, H.S., Desveaux, D., Singer, A.U., Patel, P., Sondek, J., Dangl, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  16. Electrophysiological characterization of the Arabidopsis avrRpt2-specific hypersensitive response in the absence of other bacterial signals. Pike, S.M., Zhang, X.C., Gassmann, W. Plant Physiol. (2005) [Pubmed]
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