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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Calcium to creatinine ratio in a spot sample of urine for early prediction of pre-eclampsia.

OBJECTIVES: Based on the fact that urinary calcium excretion decreases in pre-eclampsia, this study was designed to determine the predictive value of calcium to creatinine ratio in a spot urine sample. METHODS: The calcium to creatinine ratio was measured in a spot urine sample of 102 normotensive women at 20-24 weeks' gestation who attended the prenatal care clinic of the Shiraz University of Medical Sciences. The women were followed-up until delivery and grouped according to pre-eclampsia occurrence. The prevalence of pre-eclampsia was measured and compared with the calcium to creatinine ratio. RESULTS: Ninety-four women remained normotensive during pregnancy and eight developed pre-eclampsia. Mean age, gestational age at the beginning of the study, and gestational age at delivery did not differ significantly between the two groups. Mean urinary calcium concentration (15.9+/-8.5 mg/dl in normotensive vs. 10.2+/-7.5 mg/dl in pre-eclamptic women), and mean birth weight (3192+/-336.3 g vs. 2712+/-468.9 g) were significantly lower in pre-eclamptic patients (P=0.03 and 0.005, respectively). Mean calcium to creatinine ratio was also significantly lower in the pre-eclamptic group (P<0.03). CONCLUSIONS: Single urine calcium to creatinine ratio may be an effective method for screening women at greatest risk for pre-eclampsia.[1]


  1. Calcium to creatinine ratio in a spot sample of urine for early prediction of pre-eclampsia. Kazerooni, T., Hamze-Nejadi, S. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (2003) [Pubmed]
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